DHRS7 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	37 studies	39% ± 13%	Explore
CD8-positive, alpha-beta T cell	28 studies	29% ± 9%	Explore
CD4-positive, alpha-beta T cell	25 studies	24% ± 7%	Explore
fibroblast	22 studies	25% ± 10%	Explore
regulatory T cell	20 studies	25% ± 6%	Explore
T cell	19 studies	23% ± 6%	Explore
endothelial cell	19 studies	26% ± 10%	Explore
plasmacytoid dendritic cell	19 studies	52% ± 16%	Explore
macrophage	18 studies	24% ± 8%	Explore
mature NK T cell	17 studies	41% ± 11%	Explore
gamma-delta T cell	17 studies	36% ± 10%	Explore
conventional dendritic cell	16 studies	29% ± 15%	Explore
classical monocyte	16 studies	27% ± 11%	Explore
mast cell	15 studies	32% ± 6%	Explore
pericyte	15 studies	22% ± 7%	Explore
B cell	14 studies	20% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	36% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	48% ± 12%	Explore
smooth muscle cell	12 studies	23% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	31% ± 8%	Explore
non-classical monocyte	12 studies	30% ± 13%	Explore
endothelial cell of lymphatic vessel	11 studies	29% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	28% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	23% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	31% ± 8%	Explore
capillary endothelial cell	11 studies	21% ± 5%	Explore
mucosal invariant T cell	11 studies	37% ± 10%	Explore
connective tissue cell	10 studies	22% ± 4%	Explore
plasma cell	9 studies	32% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	34% ± 11%	Explore
memory B cell	9 studies	22% ± 4%	Explore
basal cell	8 studies	31% ± 14%	Explore
naive B cell	8 studies	19% ± 3%	Explore
myofibroblast cell	8 studies	22% ± 7%	Explore
endothelial cell of vascular tree	8 studies	21% ± 5%	Explore
innate lymphoid cell	7 studies	34% ± 11%	Explore
dendritic cell	7 studies	36% ± 20%	Explore
myeloid cell	7 studies	30% ± 11%	Explore
epithelial cell	7 studies	44% ± 22%	Explore
astrocyte	7 studies	30% ± 12%	Explore
monocyte	7 studies	22% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	33% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	35% ± 11%	Explore
enterocyte	6 studies	45% ± 13%	Explore
retinal cone cell	6 studies	56% ± 27%	Explore
vein endothelial cell	6 studies	19% ± 2%	Explore
T follicular helper cell	6 studies	32% ± 6%	Explore
oligodendrocyte precursor cell	6 studies	27% ± 11%	Explore
type II pneumocyte	5 studies	36% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	37% ± 12%	Explore
hematopoietic precursor cell	5 studies	28% ± 11%	Explore
ionocyte	5 studies	46% ± 10%	Explore
leukocyte	5 studies	27% ± 11%	Explore
renal alpha-intercalated cell	5 studies	82% ± 5%	Explore
goblet cell	5 studies	30% ± 11%	Explore
abnormal cell	5 studies	25% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	33% ± 7%	Explore
alveolar macrophage	4 studies	20% ± 3%	Explore
neutrophil	4 studies	27% ± 7%	Explore
secretory cell	4 studies	35% ± 17%	Explore
exhausted T cell	4 studies	35% ± 4%	Explore
enteroendocrine cell	4 studies	32% ± 13%	Explore
kidney loop of Henle epithelial cell	4 studies	27% ± 14%	Explore
retinal rod cell	4 studies	26% ± 14%	Explore
microglial cell	4 studies	39% ± 15%	Explore
ciliated cell	4 studies	35% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	25% ± 8%	Explore
luminal cell of prostate epithelium	4 studies	42% ± 14%	Explore
glutamatergic neuron	4 studies	27% ± 10%	Explore
T-helper 17 cell	4 studies	24% ± 8%	Explore
hematopoietic stem cell	4 studies	26% ± 5%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	26% ± 9%	Explore
duct epithelial cell	3 studies	22% ± 1%	Explore
respiratory goblet cell	3 studies	27% ± 13%	Explore
pancreatic A cell	3 studies	28% ± 4%	Explore
pancreatic D cell	3 studies	44% ± 20%	Explore
type B pancreatic cell	3 studies	60% ± 19%	Explore
plasmablast	3 studies	36% ± 18%	Explore
retinal ganglion cell	3 studies	54% ± 25%	Explore
renal principal cell	3 studies	58% ± 8%	Explore
lymphocyte	3 studies	29% ± 14%	Explore
club cell	3 studies	31% ± 5%	Explore
endothelial cell of artery	3 studies	18% ± 1%	Explore
intraepithelial lymphocyte	3 studies	35% ± 2%	Explore
Mueller cell	3 studies	24% ± 3%	Explore
CD4-positive helper T cell	3 studies	26% ± 8%	Explore
GABAergic neuron	3 studies	29% ± 4%	Explore
pancreatic ductal cell	3 studies	72% ± 9%	Explore
granulocyte	3 studies	33% ± 13%	Explore
group 3 innate lymphoid cell	3 studies	39% ± 10%	Explore
mononuclear phagocyte	3 studies	19% ± 1%	Explore
oligodendrocyte	3 studies	25% ± 5%	Explore
T-helper 1 cell	3 studies	33% ± 5%	Explore
double negative thymocyte	3 studies	40% ± 7%	Explore
interneuron	3 studies	22% ± 9%	Explore
neuron	3 studies	31% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	29% ± 8%	Explore
lung	15 studies	27% ± 11%	Explore
intestine	8 studies	24% ± 6%	Explore
lymph node	5 studies	24% ± 6%	Explore
brain	5 studies	30% ± 9%	Explore
liver	5 studies	19% ± 4%	Explore
pancreas	4 studies	38% ± 14%	Explore
kidney	4 studies	32% ± 4%	Explore
eye	4 studies	28% ± 14%	Explore
uterus	4 studies	28% ± 7%	Explore
breast	4 studies	19% ± 3%	Explore
adrenal gland	3 studies	28% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	9152.43	245 / 245	100%	537.10	502 / 502
breast	100%	3051.42	459 / 459	100%	76.05	1114 / 1118
thymus	100%	4572.01	653 / 653	99%	82.31	601 / 605
intestine	100%	3518.26	965 / 966	98%	53.10	519 / 527
kidney	100%	3122.04	89 / 89	98%	88.74	884 / 901
brain	98%	2120.03	2597 / 2642	100%	54.89	703 / 705
skin	99%	2277.84	1797 / 1809	98%	56.51	463 / 472
liver	99%	2871.69	224 / 226	98%	76.85	399 / 406
lung	99%	3029.41	573 / 578	98%	53.18	1133 / 1155
pancreas	99%	1762.54	324 / 328	98%	63.93	175 / 178
esophagus	100%	2148.84	1440 / 1445	97%	33.46	178 / 183
adrenal gland	100%	5372.47	258 / 258	97%	83.02	222 / 230
bladder	100%	2464.86	21 / 21	96%	47.22	483 / 504
stomach	100%	4235.74	359 / 359	95%	40.72	272 / 286
uterus	100%	2799.96	170 / 170	95%	37.47	435 / 459
ovary	100%	2823.72	180 / 180	65%	14.79	281 / 430
adipose	100%	3065.58	1204 / 1204	0%	0	0 / 0
muscle	100%	19507.35	803 / 803	0%	0	0 / 0
spleen	100%	2338.48	241 / 241	0%	0	0 / 0
blood vessel	100%	3725.11	1334 / 1335	0%	0	0 / 0
peripheral blood	100%	7528.49	927 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	99%	71.37	79 / 80
tonsil	0%	0	0 / 0	98%	32.09	44 / 45
lymph node	0%	0	0 / 0	97%	33.90	28 / 29
heart	92%	1611.19	796 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

IV. Literature review

[source]

Gene name	DHRS7
Protein name	Dehydrogenase/reductase 7 Dehydrogenase/reductase SDR family member 7 (EC 1.1.1.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1) (Protein SDR34C1)
Synonyms	CGI-86 RETSDR4 DHRS7A SDR34C1 UNQ285/PRO3448
Description	FUNCTION: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics . Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function . Involved in the reduction of all-trans-retinal to all-trans-retinol . Converts cortisone to 20beta-dihydrocortisone in vitro, although the physiological relevance of this activity is questionable . Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group . A dehydrogenase activity has not been detected so far . May play a role as tumor suppressor . .
Accessions	ENST00000557137.1 ENST00000554101.5 ENST00000557185.6 [Q9Y394-1] H0YJ66 ENST00000557326.1 H0YJR8 G3V5J0 H0YJE4 Q9Y394 ENST00000557751.5 ENST00000536410.6 [Q9Y394-2] ENST00000216500.9 [Q9Y394-1]

GO_0042572	Biological process	retinol metabolic process
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0004090	Molecular function	carbonyl reductase (NADPH) activity
GO_0005515	Molecular function	protein binding
GO_0016616	Molecular function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO_0052650	Molecular function	all-trans-retinol dehydrogenase (NADP+) activity

DHRS7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review