CAPZA2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	44 studies	43% ± 14%	Explore
macrophage	39 studies	42% ± 13%	Explore
fibroblast	37 studies	27% ± 11%	Explore
smooth muscle cell	28 studies	34% ± 10%	Explore
natural killer cell	27 studies	22% ± 5%	Explore
pericyte	27 studies	33% ± 11%	Explore
B cell	25 studies	23% ± 8%	Explore
classical monocyte	25 studies	39% ± 13%	Explore
conventional dendritic cell	24 studies	38% ± 13%	Explore
non-classical monocyte	23 studies	51% ± 13%	Explore
CD4-positive, alpha-beta T cell	22 studies	22% ± 6%	Explore
monocyte	20 studies	39% ± 12%	Explore
CD8-positive, alpha-beta T cell	19 studies	22% ± 5%	Explore
T cell	18 studies	23% ± 8%	Explore
regulatory T cell	18 studies	24% ± 4%	Explore
mast cell	17 studies	26% ± 7%	Explore
endothelial cell of lymphatic vessel	17 studies	29% ± 9%	Explore
capillary endothelial cell	16 studies	38% ± 12%	Explore
epithelial cell	16 studies	39% ± 23%	Explore
myofibroblast cell	15 studies	31% ± 10%	Explore
dendritic cell	14 studies	41% ± 22%	Explore
basal cell	14 studies	35% ± 14%	Explore
naive B cell	14 studies	20% ± 4%	Explore
endothelial cell of artery	14 studies	55% ± 17%	Explore
endothelial cell of vascular tree	14 studies	40% ± 13%	Explore
connective tissue cell	13 studies	33% ± 9%	Explore
vein endothelial cell	13 studies	41% ± 10%	Explore
microglial cell	13 studies	31% ± 12%	Explore
myeloid cell	13 studies	40% ± 13%	Explore
astrocyte	13 studies	31% ± 14%	Explore
gamma-delta T cell	13 studies	23% ± 11%	Explore
memory B cell	12 studies	21% ± 4%	Explore
plasmacytoid dendritic cell	12 studies	27% ± 10%	Explore
mature NK T cell	11 studies	20% ± 3%	Explore
platelet	10 studies	40% ± 13%	Explore
glutamatergic neuron	10 studies	38% ± 22%	Explore
ciliated cell	10 studies	36% ± 18%	Explore
secretory cell	9 studies	28% ± 13%	Explore
leukocyte	9 studies	28% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	20% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	22% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	23% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	23% ± 4%	Explore
mucosal invariant T cell	9 studies	19% ± 3%	Explore
type II pneumocyte	9 studies	25% ± 11%	Explore
alveolar macrophage	8 studies	42% ± 12%	Explore
type I pneumocyte	8 studies	27% ± 8%	Explore
neuron	8 studies	35% ± 14%	Explore
mesothelial cell	8 studies	27% ± 16%	Explore
abnormal cell	8 studies	37% ± 16%	Explore
oligodendrocyte precursor cell	8 studies	28% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	22% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	22% ± 7%	Explore
neutrophil	7 studies	24% ± 3%	Explore
mononuclear phagocyte	7 studies	42% ± 15%	Explore
epithelial cell of proximal tubule	7 studies	37% ± 11%	Explore
goblet cell	7 studies	29% ± 13%	Explore
oligodendrocyte	7 studies	24% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	23% ± 5%	Explore
kidney loop of Henle epithelial cell	6 studies	38% ± 8%	Explore
progenitor cell	6 studies	24% ± 5%	Explore
renal alpha-intercalated cell	6 studies	38% ± 5%	Explore
megakaryocyte	6 studies	65% ± 17%	Explore
enterocyte	6 studies	24% ± 5%	Explore
innate lymphoid cell	6 studies	25% ± 9%	Explore
retinal rod cell	6 studies	27% ± 12%	Explore
cardiac muscle cell	6 studies	31% ± 7%	Explore
T follicular helper cell	6 studies	23% ± 1%	Explore
GABAergic neuron	6 studies	39% ± 14%	Explore
interneuron	6 studies	32% ± 18%	Explore
ionocyte	5 studies	28% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	21% ± 3%	Explore
enteroendocrine cell	5 studies	35% ± 18%	Explore
retinal bipolar neuron	5 studies	34% ± 20%	Explore
OFF-bipolar cell	5 studies	32% ± 13%	Explore
ON-bipolar cell	5 studies	30% ± 15%	Explore
hematopoietic stem cell	5 studies	34% ± 13%	Explore
club cell	5 studies	27% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	22% ± 7%	Explore
erythrocyte	5 studies	29% ± 20%	Explore
hematopoietic precursor cell	4 studies	44% ± 12%	Explore
pancreatic A cell	4 studies	51% ± 14%	Explore
exhausted T cell	4 studies	26% ± 5%	Explore
glomerular endothelial cell	4 studies	49% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	45% ± 7%	Explore
retinal ganglion cell	4 studies	60% ± 29%	Explore
lymphocyte	4 studies	29% ± 10%	Explore
precursor B cell	4 studies	34% ± 8%	Explore
pro-B cell	4 studies	24% ± 5%	Explore
retina horizontal cell	4 studies	35% ± 14%	Explore
adipocyte	4 studies	20% ± 4%	Explore
Mueller cell	4 studies	39% ± 14%	Explore
endothelial cell of sinusoid	4 studies	30% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	24% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	29% ± 3%	Explore
hepatocyte	4 studies	47% ± 18%	Explore
plasmablast	3 studies	49% ± 7%	Explore
respiratory goblet cell	3 studies	27% ± 15%	Explore
squamous epithelial cell	3 studies	41% ± 26%	Explore
pancreatic D cell	3 studies	43% ± 18%	Explore
type B pancreatic cell	3 studies	56% ± 12%	Explore
neural crest cell	3 studies	26% ± 1%	Explore
erythroblast	3 studies	44% ± 31%	Explore
plasma cell	3 studies	30% ± 12%	Explore
immature B cell	3 studies	23% ± 8%	Explore
amacrine cell	3 studies	45% ± 10%	Explore
retinal pigment epithelial cell	3 studies	37% ± 19%	Explore
tissue-resident macrophage	3 studies	40% ± 9%	Explore
rod bipolar cell	3 studies	33% ± 5%	Explore
acinar cell	3 studies	36% ± 20%	Explore
germinal center B cell	3 studies	23% ± 3%	Explore
intermediate monocyte	3 studies	56% ± 17%	Explore
inflammatory macrophage	3 studies	29% ± 5%	Explore
granulocyte	3 studies	35% ± 10%	Explore
pancreatic ductal cell	3 studies	62% ± 13%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	49% ± 23%	Explore
brush cell	3 studies	25% ± 13%	Explore
glial cell	3 studies	33% ± 17%	Explore
group 3 innate lymphoid cell	3 studies	27% ± 8%	Explore
melanocyte	3 studies	24% ± 4%	Explore
T-helper 17 cell	3 studies	23% ± 3%	Explore
granule cell	3 studies	24% ± 9%	Explore
T-helper 1 cell	3 studies	22% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	20% ± 4%	Explore
double negative thymocyte	3 studies	32% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	33% ± 13%	Explore
peripheral blood	15 studies	29% ± 8%	Explore
brain	15 studies	31% ± 15%	Explore
eye	10 studies	29% ± 11%	Explore
intestine	9 studies	24% ± 12%	Explore
kidney	9 studies	31% ± 6%	Explore
heart	6 studies	24% ± 5%	Explore
liver	5 studies	40% ± 26%	Explore
pancreas	4 studies	47% ± 17%	Explore
uterus	4 studies	38% ± 17%	Explore
lymph node	4 studies	26% ± 10%	Explore
breast	4 studies	26% ± 2%	Explore
adipose	4 studies	19% ± 2%	Explore
bone marrow	3 studies	26% ± 7%	Explore
placenta	3 studies	31% ± 9%	Explore
prostate	3 studies	24% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5975.59	1445 / 1445	100%	41.50	183 / 183
ovary	100%	3434.39	180 / 180	100%	43.77	430 / 430
uterus	100%	5522.44	170 / 170	100%	38.12	459 / 459
lung	100%	6256.12	578 / 578	100%	59.29	1154 / 1155
kidney	100%	5521.39	89 / 89	100%	67.42	900 / 901
breast	100%	6033.57	459 / 459	100%	47.00	1116 / 1118
brain	100%	4258.93	2635 / 2642	100%	72.43	705 / 705
thymus	100%	4772.60	653 / 653	99%	48.18	601 / 605
stomach	100%	4234.63	359 / 359	99%	56.72	284 / 286
prostate	100%	4383.39	244 / 245	100%	40.46	500 / 502
intestine	100%	7130.20	966 / 966	99%	55.30	522 / 527
bladder	100%	6325.19	21 / 21	99%	45.63	497 / 504
adrenal gland	100%	5317.71	258 / 258	98%	31.45	225 / 230
liver	100%	2620.04	225 / 226	97%	27.94	395 / 406
skin	99%	4299.41	1794 / 1809	95%	41.05	447 / 472
pancreas	93%	2074.44	306 / 328	99%	46.00	176 / 178
blood vessel	100%	8249.85	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	33.29	29 / 29
muscle	100%	7834.04	803 / 803	0%	0	0 / 0
spleen	100%	4789.66	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	30.27	45 / 45
ureter	0%	0	0 / 0	100%	13.62	1 / 1
adipose	100%	6949.87	1203 / 1204	0%	0	0 / 0
heart	98%	6381.83	844 / 861	0%	0	0 / 0
peripheral blood	86%	4862.90	795 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	64%	13.80	51 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030036	Biological process	actin cytoskeleton organization
GO_0051016	Biological process	barbed-end actin filament capping
GO_0065003	Biological process	protein-containing complex assembly
GO_0008290	Cellular component	F-actin capping protein complex
GO_0005903	Cellular component	brush border
GO_0030863	Cellular component	cortical cytoskeleton
GO_0015629	Cellular component	actin cytoskeleton
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005576	Cellular component	extracellular region
GO_0016020	Cellular component	membrane
GO_0051015	Molecular function	actin filament binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CAPZA2
Protein name	Capping actin protein of muscle Z-line subunit alpha 2 F-actin-capping protein subunit alpha-2 (CapZ alpha-2) F-actin-capping protein subunit alpha
Synonyms	hCG_37884 tcag7.31
Description	FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. . FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. . FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. .
Accessions	ENST00000484325.1 ENST00000449080.5 P47755 ENST00000490693.5 C9JUG7 ENST00000361183.8 [P47755-1] ENST00000464223.5 C9JCZ4 A4D0V4 ENST00000426421.5 F8W9N7 F8WED3 C9J7V0

CAPZA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review