ATRAID | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	34 studies	40% ± 15%	Explore
endothelial cell	28 studies	33% ± 15%	Explore
natural killer cell	27 studies	24% ± 7%	Explore
CD4-positive, alpha-beta T cell	25 studies	23% ± 6%	Explore
CD8-positive, alpha-beta T cell	25 studies	24% ± 6%	Explore
macrophage	24 studies	28% ± 9%	Explore
pericyte	21 studies	31% ± 9%	Explore
smooth muscle cell	20 studies	31% ± 9%	Explore
regulatory T cell	19 studies	27% ± 6%	Explore
B cell	18 studies	24% ± 7%	Explore
T cell	18 studies	23% ± 7%	Explore
connective tissue cell	18 studies	39% ± 14%	Explore
endothelial cell of lymphatic vessel	17 studies	41% ± 11%	Explore
conventional dendritic cell	17 studies	28% ± 15%	Explore
plasma cell	17 studies	41% ± 16%	Explore
basal cell	17 studies	36% ± 18%	Explore
non-classical monocyte	17 studies	29% ± 13%	Explore
epithelial cell	16 studies	41% ± 23%	Explore
ciliated cell	15 studies	46% ± 18%	Explore
classical monocyte	15 studies	26% ± 11%	Explore
plasmacytoid dendritic cell	15 studies	31% ± 11%	Explore
memory B cell	14 studies	21% ± 5%	Explore
naive B cell	13 studies	21% ± 4%	Explore
mature NK T cell	13 studies	25% ± 5%	Explore
myofibroblast cell	13 studies	37% ± 11%	Explore
gamma-delta T cell	13 studies	27% ± 9%	Explore
mast cell	12 studies	25% ± 4%	Explore
capillary endothelial cell	12 studies	27% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	27% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	26% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	28% ± 5%	Explore
monocyte	11 studies	22% ± 7%	Explore
vein endothelial cell	11 studies	28% ± 9%	Explore
plasmablast	10 studies	37% ± 23%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	25% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	26% ± 8%	Explore
abnormal cell	9 studies	37% ± 15%	Explore
endothelial cell of artery	9 studies	29% ± 6%	Explore
mucosal invariant T cell	9 studies	25% ± 3%	Explore
endothelial cell of vascular tree	9 studies	29% ± 7%	Explore
type I pneumocyte	8 studies	29% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	26% ± 5%	Explore
secretory cell	8 studies	35% ± 14%	Explore
dendritic cell	8 studies	34% ± 19%	Explore
myeloid cell	8 studies	28% ± 11%	Explore
club cell	7 studies	33% ± 13%	Explore
epithelial cell of proximal tubule	7 studies	29% ± 12%	Explore
progenitor cell	7 studies	28% ± 10%	Explore
goblet cell	7 studies	26% ± 13%	Explore
mesothelial cell	7 studies	37% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	24% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	29% ± 6%	Explore
kidney loop of Henle epithelial cell	6 studies	34% ± 10%	Explore
renal alpha-intercalated cell	6 studies	50% ± 8%	Explore
type II pneumocyte	6 studies	38% ± 16%	Explore
T follicular helper cell	6 studies	26% ± 2%	Explore
alveolar macrophage	5 studies	26% ± 6%	Explore
ionocyte	5 studies	31% ± 8%	Explore
leukocyte	5 studies	22% ± 6%	Explore
enteroendocrine cell	5 studies	34% ± 17%	Explore
intestinal crypt stem cell	5 studies	24% ± 5%	Explore
IgA plasma cell	5 studies	23% ± 7%	Explore
innate lymphoid cell	5 studies	21% ± 5%	Explore
hematopoietic precursor cell	4 studies	41% ± 14%	Explore
mononuclear phagocyte	4 studies	32% ± 18%	Explore
exhausted T cell	4 studies	32% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	44% ± 6%	Explore
IgG plasma cell	4 studies	26% ± 6%	Explore
hematopoietic stem cell	4 studies	24% ± 6%	Explore
adventitial cell	4 studies	44% ± 13%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	32% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	35% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	32% ± 9%	Explore
T-helper 17 cell	4 studies	20% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	24% ± 5%	Explore
duct epithelial cell	3 studies	27% ± 4%	Explore
pancreatic A cell	3 studies	62% ± 8%	Explore
type B pancreatic cell	3 studies	53% ± 13%	Explore
glomerular endothelial cell	3 studies	29% ± 6%	Explore
enterocyte	3 studies	20% ± 2%	Explore
neural crest cell	3 studies	29% ± 2%	Explore
extravillous trophoblast	3 studies	39% ± 19%	Explore
common myeloid progenitor	3 studies	35% ± 18%	Explore
lymphocyte	3 studies	32% ± 8%	Explore
astrocyte	3 studies	34% ± 20%	Explore
serous secreting cell	3 studies	36% ± 14%	Explore
intraepithelial lymphocyte	3 studies	25% ± 6%	Explore
Mueller cell	3 studies	30% ± 9%	Explore
intermediate monocyte	3 studies	37% ± 18%	Explore
myoepithelial cell	3 studies	32% ± 9%	Explore
neuron	3 studies	31% ± 15%	Explore
glial cell	3 studies	37% ± 20%	Explore
group 3 innate lymphoid cell	3 studies	27% ± 11%	Explore
transit amplifying cell	3 studies	20% ± 1%	Explore
T-helper 1 cell	3 studies	25% ± 4%	Explore
double negative thymocyte	3 studies	35% ± 11%	Explore
progenitor cell of mammary luminal epithelium	3 studies	22% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	32% ± 13%	Explore
peripheral blood	14 studies	28% ± 7%	Explore
intestine	11 studies	26% ± 13%	Explore
kidney	8 studies	30% ± 7%	Explore
lymph node	5 studies	28% ± 14%	Explore
eye	4 studies	28% ± 11%	Explore
uterus	4 studies	43% ± 11%	Explore
breast	4 studies	27% ± 5%	Explore
liver	4 studies	26% ± 13%	Explore
pancreas	3 studies	52% ± 17%	Explore
placenta	3 studies	40% ± 17%	Explore
bone marrow	3 studies	20% ± 2%	Explore
adrenal gland	3 studies	21% ± 4%	Explore
skin	3 studies	22% ± 3%	Explore
brain	3 studies	28% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3791.02	1445 / 1445	100%	121.60	183 / 183
kidney	100%	4658.02	89 / 89	100%	169.68	901 / 901
ovary	100%	5646.84	180 / 180	100%	216.00	430 / 430
pancreas	100%	2665.03	328 / 328	100%	137.83	178 / 178
prostate	100%	4212.44	245 / 245	100%	161.30	502 / 502
skin	100%	4398.70	1809 / 1809	100%	161.84	472 / 472
stomach	100%	3724.81	359 / 359	100%	134.67	286 / 286
breast	100%	5196.39	459 / 459	100%	170.56	1117 / 1118
thymus	100%	5738.17	653 / 653	100%	231.88	604 / 605
lung	100%	4005.80	578 / 578	100%	184.26	1153 / 1155
uterus	100%	4923.54	170 / 170	100%	171.11	458 / 459
intestine	100%	4175.22	966 / 966	100%	146.42	525 / 527
bladder	100%	4701.95	21 / 21	99%	163.50	501 / 504
liver	100%	1628.58	225 / 226	100%	90.02	405 / 406
adrenal gland	100%	5167.62	258 / 258	99%	131.79	228 / 230
brain	99%	1791.83	2615 / 2642	100%	138.42	704 / 705
adipose	100%	4833.26	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	161.94	80 / 80
lymph node	0%	0	0 / 0	100%	106.58	29 / 29
spleen	100%	3713.78	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	121.72	45 / 45
ureter	0%	0	0 / 0	100%	121.45	1 / 1
blood vessel	100%	4653.37	1334 / 1335	0%	0	0 / 0
muscle	100%	3594.89	802 / 803	0%	0	0 / 0
heart	99%	4407.81	856 / 861	0%	0	0 / 0
peripheral blood	96%	2339.78	893 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042177	Biological process	negative regulation of protein catabolic process
GO_0010468	Biological process	regulation of gene expression
GO_0006855	Biological process	xenobiotic transmembrane transport
GO_0030154	Biological process	cell differentiation
GO_0030501	Biological process	positive regulation of bone mineralization
GO_0045669	Biological process	positive regulation of osteoblast differentiation
GO_0033689	Biological process	negative regulation of osteoblast proliferation
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005886	Cellular component	plasma membrane
GO_0005765	Cellular component	lysosomal membrane
GO_0005635	Cellular component	nuclear envelope
GO_0042910	Molecular function	xenobiotic transmembrane transporter activity
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

IV. Literature review

[source]

Gene name	ATRAID
Protein name	All-trans retinoic acid induced differentiation factor All-trans retinoic acid-induced differentiation factor (Apoptosis-related protein 3) (APR-3) (p18)
Synonyms	HSPC013 UNQ214/PRO240 APR3 C2orf28
Description	FUNCTION: Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol . .
Accessions	ENST00000419744.1 ENST00000405489.7 [Q6UW56-2] ENST00000380171.9 [Q6UW56-1] Q6UW56 C9JA62

ATRAID report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review