ASAH1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	47 studies	58% ± 19%	Explore
pericyte	31 studies	32% ± 13%	Explore
classical monocyte	28 studies	62% ± 15%	Explore
mast cell	26 studies	44% ± 16%	Explore
non-classical monocyte	25 studies	76% ± 16%	Explore
endothelial cell	25 studies	27% ± 10%	Explore
monocyte	24 studies	51% ± 15%	Explore
natural killer cell	24 studies	22% ± 5%	Explore
smooth muscle cell	23 studies	26% ± 10%	Explore
conventional dendritic cell	23 studies	38% ± 17%	Explore
B cell	20 studies	24% ± 7%	Explore
fibroblast	20 studies	27% ± 10%	Explore
epithelial cell	19 studies	49% ± 23%	Explore
myeloid cell	18 studies	47% ± 22%	Explore
ciliated cell	17 studies	36% ± 14%	Explore
microglial cell	16 studies	42% ± 17%	Explore
memory B cell	16 studies	21% ± 5%	Explore
dendritic cell	14 studies	37% ± 18%	Explore
basal cell	14 studies	32% ± 19%	Explore
neutrophil	13 studies	40% ± 12%	Explore
secretory cell	12 studies	41% ± 20%	Explore
type I pneumocyte	11 studies	57% ± 19%	Explore
type II pneumocyte	11 studies	62% ± 23%	Explore
naive B cell	11 studies	20% ± 4%	Explore
platelet	10 studies	37% ± 11%	Explore
club cell	10 studies	47% ± 18%	Explore
astrocyte	10 studies	31% ± 12%	Explore
plasma cell	9 studies	30% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	27% ± 5%	Explore
myofibroblast cell	9 studies	22% ± 9%	Explore
alveolar macrophage	8 studies	72% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	26% ± 4%	Explore
mesothelial cell	8 studies	26% ± 13%	Explore
endothelial cell of lymphatic vessel	8 studies	25% ± 9%	Explore
gamma-delta T cell	8 studies	19% ± 4%	Explore
plasmacytoid dendritic cell	7 studies	22% ± 6%	Explore
epithelial cell of proximal tubule	7 studies	38% ± 10%	Explore
capillary endothelial cell	7 studies	20% ± 2%	Explore
leukocyte	7 studies	38% ± 10%	Explore
adipocyte	7 studies	25% ± 10%	Explore
connective tissue cell	7 studies	26% ± 8%	Explore
respiratory goblet cell	6 studies	53% ± 13%	Explore
mature NK T cell	6 studies	20% ± 4%	Explore
neuron	6 studies	33% ± 13%	Explore
abnormal cell	6 studies	26% ± 7%	Explore
cardiac muscle cell	6 studies	45% ± 9%	Explore
oligodendrocyte	6 studies	23% ± 6%	Explore
intermediate monocyte	6 studies	62% ± 25%	Explore
oligodendrocyte precursor cell	6 studies	28% ± 8%	Explore
goblet cell	6 studies	35% ± 16%	Explore
mononuclear phagocyte	5 studies	60% ± 15%	Explore
kidney loop of Henle epithelial cell	5 studies	33% ± 10%	Explore
retinal ganglion cell	5 studies	68% ± 27%	Explore
hematopoietic stem cell	5 studies	34% ± 12%	Explore
innate lymphoid cell	5 studies	24% ± 10%	Explore
amacrine cell	5 studies	40% ± 15%	Explore
endothelial cell of artery	5 studies	16% ± 1%	Explore
Mueller cell	5 studies	62% ± 22%	Explore
glutamatergic neuron	5 studies	46% ± 19%	Explore
hematopoietic precursor cell	4 studies	32% ± 16%	Explore
plasmablast	4 studies	35% ± 19%	Explore
pancreatic A cell	4 studies	51% ± 12%	Explore
type B pancreatic cell	4 studies	44% ± 18%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	37% ± 6%	Explore
enterocyte	4 studies	23% ± 8%	Explore
progenitor cell	4 studies	33% ± 23%	Explore
immature B cell	4 studies	21% ± 3%	Explore
retina horizontal cell	4 studies	41% ± 11%	Explore
retinal pigment epithelial cell	4 studies	51% ± 26%	Explore
mucus secreting cell	4 studies	31% ± 12%	Explore
inflammatory macrophage	4 studies	57% ± 15%	Explore
endothelial cell of vascular tree	4 studies	23% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	35% ± 8%	Explore
luminal cell of prostate epithelium	4 studies	23% ± 5%	Explore
GABAergic neuron	4 studies	44% ± 16%	Explore
erythrocyte	4 studies	25% ± 13%	Explore
enteroendocrine cell	4 studies	32% ± 21%	Explore
interneuron	4 studies	36% ± 18%	Explore
mucosal invariant T cell	4 studies	17% ± 2%	Explore
duct epithelial cell	3 studies	50% ± 13%	Explore
ionocyte	3 studies	34% ± 11%	Explore
squamous epithelial cell	3 studies	58% ± 14%	Explore
pancreatic D cell	3 studies	47% ± 14%	Explore
T cell	3 studies	31% ± 16%	Explore
CD4-positive, alpha-beta T cell	3 studies	19% ± 1%	Explore
CD8-positive, alpha-beta T cell	3 studies	20% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	22% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
retinal bipolar neuron	3 studies	36% ± 11%	Explore
common myeloid progenitor	3 studies	33% ± 20%	Explore
megakaryocyte	3 studies	52% ± 3%	Explore
neuroendocrine cell	3 studies	44% ± 17%	Explore
retinal cone cell	3 studies	43% ± 8%	Explore
retinal rod cell	3 studies	28% ± 5%	Explore
serous secreting cell	3 studies	29% ± 1%	Explore
tissue-resident macrophage	3 studies	63% ± 22%	Explore
OFF-bipolar cell	3 studies	43% ± 24%	Explore
ON-bipolar cell	3 studies	44% ± 25%	Explore
rod bipolar cell	3 studies	29% ± 8%	Explore
endothelial cell of sinusoid	3 studies	20% ± 2%	Explore
granulocyte	3 studies	47% ± 16%	Explore
muscle cell	3 studies	29% ± 11%	Explore
pancreatic ductal cell	3 studies	60% ± 18%	Explore
intestinal crypt stem cell	3 studies	22% ± 4%	Explore
glial cell	3 studies	33% ± 10%	Explore
hepatocyte	3 studies	40% ± 17%	Explore
group 3 innate lymphoid cell	3 studies	21% ± 5%	Explore
melanocyte	3 studies	44% ± 8%	Explore
regulatory T cell	3 studies	16% ± 2%	Explore
double negative thymocyte	3 studies	20% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	38% ± 12%	Explore
peripheral blood	18 studies	30% ± 8%	Explore
brain	11 studies	34% ± 17%	Explore
kidney	9 studies	29% ± 7%	Explore
intestine	8 studies	22% ± 9%	Explore
eye	8 studies	36% ± 11%	Explore
placenta	5 studies	25% ± 7%	Explore
heart	5 studies	26% ± 3%	Explore
pancreas	4 studies	43% ± 16%	Explore
bone marrow	4 studies	20% ± 4%	Explore
uterus	4 studies	33% ± 12%	Explore
adipose	4 studies	27% ± 5%	Explore
liver	4 studies	30% ± 13%	Explore
skin	3 studies	16% ± 1%	Explore
thymus	3 studies	21% ± 5%	Explore
breast	3 studies	23% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	8456.96	244 / 245	99%	62.80	499 / 502
breast	100%	10987.84	459 / 459	98%	85.31	1101 / 1118
lung	100%	17163.61	578 / 578	98%	55.09	1137 / 1155
brain	99%	6583.23	2608 / 2642	100%	55.52	703 / 705
skin	100%	7477.66	1803 / 1809	98%	111.10	462 / 472
kidney	100%	11242.85	89 / 89	97%	62.00	874 / 901
thymus	100%	25263.37	653 / 653	96%	108.03	581 / 605
bladder	100%	9582.10	21 / 21	95%	39.78	481 / 504
intestine	100%	6625.43	966 / 966	94%	27.94	497 / 527
stomach	99%	4475.56	356 / 359	94%	30.76	270 / 286
ovary	100%	4727.99	180 / 180	91%	23.45	393 / 430
esophagus	100%	6658.98	1444 / 1445	91%	24.04	166 / 183
uterus	100%	6644.71	170 / 170	89%	28.05	407 / 459
adrenal gland	98%	7298.58	254 / 258	89%	35.81	205 / 230
pancreas	88%	3200.97	290 / 328	98%	36.36	175 / 178
liver	76%	2672.54	172 / 226	46%	12.91	185 / 406
adipose	100%	14458.59	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	120.68	80 / 80
spleen	100%	9767.50	241 / 241	0%	0	0 / 0
blood vessel	99%	9022.07	1328 / 1335	0%	0	0 / 0
peripheral blood	99%	15791.74	921 / 929	0%	0	0 / 0
heart	98%	25815.21	844 / 861	0%	0	0 / 0
muscle	96%	5361.43	768 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	35.73	27 / 29
tonsil	0%	0	0 / 0	89%	24.96	40 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0030216	Biological process	keratinocyte differentiation
GO_0006631	Biological process	fatty acid metabolic process
GO_0046514	Biological process	ceramide catabolic process
GO_0050810	Biological process	regulation of steroid biosynthetic process
GO_0046513	Biological process	ceramide biosynthetic process
GO_0071356	Biological process	cellular response to tumor necrosis factor
GO_0046512	Biological process	sphingosine biosynthetic process
GO_0062098	Biological process	regulation of programmed necrotic cell death
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005769	Cellular component	early endosome
GO_0005764	Cellular component	lysosome
GO_0070062	Cellular component	extracellular exosome
GO_1904724	Cellular component	tertiary granule lumen
GO_1904813	Cellular component	ficolin-1-rich granule lumen
GO_0005783	Cellular component	endoplasmic reticulum
GO_0043202	Cellular component	lysosomal lumen
GO_0005634	Cellular component	nucleus
GO_0017040	Molecular function	N-acylsphingosine amidohydrolase activity
GO_0102121	Molecular function	ceramidase activity
GO_0017064	Molecular function	fatty acid amide hydrolase activity
GO_0016811	Molecular function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ASAH1
Protein name	N-acylsphingosine amidohydrolase 1 Acid ceramidase (EC 3.5.1.23) ceramidase (EC 3.5.1.23) Acid ceramidase (AC) (ACDase) (Acid CDase) (EC 3.5.1.23) (Acylsphingosine deacylase) (N-acylethanolamine hydrolase ASAH1) (EC 3.5.1.-) (N-acylsphingosine amidohydrolase) (Putative 32 kDa heart protein) (PHP32) [Cleaved into: Acid ceramidase subunit alpha; Acid ceramidase subunit beta]
Synonyms	HSD-33 HSD33 ASAH
Description	FUNCTION: Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH . Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation . Has a higher catalytic efficiency towards C12-ceramides versus other ceramides . Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine . For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used . Has also an N-acylethanolamine hydrolase activity . By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes . Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (By similarity). By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis . .; FUNCTION: [Isoform 2]: May directly regulate steroidogenesis by binding the nuclear receptor NR5A1 and negatively regulating its transcriptional activity. .
Accessions	ENST00000635944.1 ENST00000637792.1 ENST00000636269.1 ENST00000637805.1 B1B5T0 ENST00000636160.1 ENST00000637718.1 ENST00000636715.1 ENST00000637484.1 ENST00000636128.1 ENST00000520781.6 ENST00000637244.1 B1B5Q8 ENST00000636299.1 A0A1B0GUJ2 A0A1B0GV06 A0A1B0GVE7 A0A1B0GV88 ENST00000637013.1 B1B5Q0 B1B5S6 ENST00000637872.1 B1B5R9 E7EMM4 ENST00000637922.1 ENST00000636455.1 ENST00000637636.1 A0A1B0GW68 Q13510 ENST00000637991.1 ENST00000636997.1 ENST00000635756.1 ENST00000518087.7 ENST00000636171.1 ENST00000636691.1 B1B5R8 A0A1B0GUH5 ENST00000381733.9 [Q13510-2] A0A1B0GTD4 ENST00000636920.1 A0A1B0GUW4 ENST00000637790.2 [Q13510-1] ENST00000637536.1 A0A1B0GVJ1 A0A1B0GTQ7 ENST00000637429.1 ENST00000637638.1 ENST00000520051.2 A0A1B0GTP7 B1B5Q3 B1B5P7 ENST00000636815.1 A0A1B0GWC9 ENST00000635998.1 [Q13510-1] B1B5S8 B1B5Q9 ENST00000519468.5 A0A1B0GU70 ENST00000636033.1 ENST00000636050.1 A0A1B0GU06 A0A1B0GV95 A0A1B0GW48 A0A1B0GUP1 ENST00000637946.1 B1B5Q2 ENST00000314146.10 [Q13510-3] A0A1B0GVC9 A0A1B0GUB3 A0A1B0GUQ5 ENST00000637561.1 ENST00000637603.1 B1B5S7 A0A1B0GUJ3 ENST00000636577.1 A0A1B0GTX9 ENST00000636537.1 A0A1B0GU62 ENST00000636701.1 A0A1B0GVY5 A0A1B0GW30 A0A1B0GTM3 A0A1B0GVA3 A0A1B0GUG1 ENST00000637202.1 A0A1B0GUE3 A0A1B0GVL2 A0A1B0GTZ5 B1B5P6 A0A1B0GVG2 B1B5T7 ENST00000523593.6 ENST00000635769.1 A0A1B0GW66 A0A1B0GVA8 ENST00000637528.1 ENST00000636823.1 ENST00000636494.1 B1B5S5 A0A1B0GUA4 A0A1B0GTA6 ENST00000637095.1 ENST00000636009.1

ASAH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review