ARL6IP5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	39 studies	48% ± 13%	Explore
CD8-positive, alpha-beta T cell	38 studies	48% ± 16%	Explore
macrophage	37 studies	43% ± 14%	Explore
T cell	36 studies	39% ± 14%	Explore
B cell	34 studies	41% ± 12%	Explore
fibroblast	34 studies	43% ± 18%	Explore
CD4-positive, alpha-beta T cell	32 studies	51% ± 14%	Explore
endothelial cell	28 studies	33% ± 11%	Explore
conventional dendritic cell	28 studies	49% ± 14%	Explore
regulatory T cell	27 studies	58% ± 17%	Explore
classical monocyte	25 studies	42% ± 14%	Explore
dendritic cell	24 studies	49% ± 22%	Explore
non-classical monocyte	24 studies	58% ± 17%	Explore
smooth muscle cell	22 studies	34% ± 14%	Explore
mast cell	21 studies	43% ± 14%	Explore
monocyte	20 studies	42% ± 12%	Explore
pericyte	20 studies	31% ± 10%	Explore
memory B cell	20 studies	44% ± 10%	Explore
plasmacytoid dendritic cell	20 studies	45% ± 12%	Explore
gamma-delta T cell	19 studies	48% ± 16%	Explore
naive B cell	19 studies	33% ± 8%	Explore
mature NK T cell	18 studies	52% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	50% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	43% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	52% ± 12%	Explore
basal cell	15 studies	34% ± 19%	Explore
connective tissue cell	15 studies	37% ± 13%	Explore
epithelial cell	15 studies	36% ± 21%	Explore
mucosal invariant T cell	14 studies	41% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	53% ± 13%	Explore
ciliated cell	14 studies	42% ± 17%	Explore
oligodendrocyte	14 studies	30% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	50% ± 17%	Explore
astrocyte	13 studies	27% ± 11%	Explore
myofibroblast cell	13 studies	39% ± 16%	Explore
endothelial cell of lymphatic vessel	12 studies	30% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	50% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	51% ± 19%	Explore
myeloid cell	12 studies	46% ± 17%	Explore
platelet	10 studies	49% ± 14%	Explore
endothelial cell of artery	10 studies	31% ± 9%	Explore
microglial cell	10 studies	31% ± 14%	Explore
type I pneumocyte	9 studies	42% ± 15%	Explore
plasma cell	9 studies	32% ± 14%	Explore
leukocyte	9 studies	41% ± 11%	Explore
neuron	9 studies	41% ± 16%	Explore
mesothelial cell	9 studies	30% ± 15%	Explore
glutamatergic neuron	9 studies	36% ± 18%	Explore
hematopoietic stem cell	9 studies	43% ± 16%	Explore
endothelial cell of vascular tree	9 studies	27% ± 7%	Explore
innate lymphoid cell	8 studies	43% ± 11%	Explore
secretory cell	8 studies	36% ± 18%	Explore
capillary endothelial cell	8 studies	28% ± 10%	Explore
retinal rod cell	8 studies	42% ± 20%	Explore
vein endothelial cell	8 studies	28% ± 7%	Explore
T follicular helper cell	8 studies	44% ± 15%	Explore
oligodendrocyte precursor cell	8 studies	35% ± 13%	Explore
type II pneumocyte	7 studies	41% ± 14%	Explore
plasmablast	7 studies	43% ± 21%	Explore
club cell	7 studies	32% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	62% ± 20%	Explore
abnormal cell	7 studies	35% ± 16%	Explore
GABAergic neuron	7 studies	37% ± 16%	Explore
alveolar macrophage	6 studies	48% ± 13%	Explore
ionocyte	6 studies	58% ± 19%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	66% ± 25%	Explore
mononuclear phagocyte	6 studies	50% ± 18%	Explore
retinal cone cell	6 studies	60% ± 25%	Explore
immature B cell	6 studies	42% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	66% ± 13%	Explore
interneuron	6 studies	33% ± 15%	Explore
CD4-positive helper T cell	5 studies	41% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	55% ± 15%	Explore
hematopoietic precursor cell	5 studies	49% ± 18%	Explore
exhausted T cell	5 studies	67% ± 12%	Explore
epithelial cell of proximal tubule	5 studies	23% ± 7%	Explore
retinal ganglion cell	5 studies	71% ± 30%	Explore
precursor B cell	5 studies	35% ± 13%	Explore
pro-B cell	5 studies	31% ± 6%	Explore
group 3 innate lymphoid cell	5 studies	58% ± 15%	Explore
cardiac muscle cell	5 studies	24% ± 6%	Explore
granulocyte	5 studies	46% ± 16%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	53% ± 20%	Explore
respiratory goblet cell	4 studies	27% ± 16%	Explore
pancreatic A cell	4 studies	40% ± 16%	Explore
progenitor cell	4 studies	27% ± 12%	Explore
renal alpha-intercalated cell	4 studies	28% ± 7%	Explore
OFF-bipolar cell	4 studies	48% ± 26%	Explore
ON-bipolar cell	4 studies	43% ± 28%	Explore
kidney loop of Henle epithelial cell	4 studies	26% ± 10%	Explore
lymphocyte	4 studies	34% ± 19%	Explore
megakaryocyte	4 studies	52% ± 14%	Explore
amacrine cell	4 studies	44% ± 15%	Explore
retina horizontal cell	4 studies	41% ± 14%	Explore
adventitial cell	4 studies	65% ± 12%	Explore
Mueller cell	4 studies	40% ± 15%	Explore
intermediate monocyte	4 studies	51% ± 22%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	33% ± 12%	Explore
adipocyte	4 studies	22% ± 8%	Explore
neutrophil	4 studies	30% ± 10%	Explore
glial cell	4 studies	32% ± 14%	Explore
T-helper 17 cell	4 studies	57% ± 15%	Explore
double negative thymocyte	4 studies	62% ± 6%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	62% ± 18%	Explore
duct epithelial cell	3 studies	30% ± 4%	Explore
pancreatic D cell	3 studies	44% ± 24%	Explore
type B pancreatic cell	3 studies	59% ± 15%	Explore
monocyte-derived dendritic cell	3 studies	53% ± 17%	Explore
glomerular endothelial cell	3 studies	29% ± 6%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	22% ± 3%	Explore
neural crest cell	3 studies	27% ± 1%	Explore
retinal bipolar neuron	3 studies	48% ± 10%	Explore
extravillous trophoblast	3 studies	62% ± 9%	Explore
placental villous trophoblast	3 studies	69% ± 18%	Explore
serous secreting cell	3 studies	31% ± 7%	Explore
intraepithelial lymphocyte	3 studies	46% ± 6%	Explore
rod bipolar cell	3 studies	37% ± 14%	Explore
acinar cell	3 studies	38% ± 23%	Explore
erythroblast	3 studies	33% ± 22%	Explore
germinal center B cell	3 studies	19% ± 2%	Explore
luminal cell of prostate epithelium	3 studies	23% ± 6%	Explore
pancreatic ductal cell	3 studies	65% ± 20%	Explore
goblet cell	3 studies	29% ± 5%	Explore
intestinal crypt stem cell	3 studies	23% ± 5%	Explore
T-helper 1 cell	3 studies	70% ± 11%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	69% ± 9%	Explore
double-positive, alpha-beta thymocyte	3 studies	63% ± 15%	Explore
progenitor cell of mammary luminal epithelium	3 studies	38% ± 13%	Explore
erythrocyte	3 studies	41% ± 17%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	50% ± 13%	Explore
lung	18 studies	40% ± 14%	Explore
brain	16 studies	33% ± 15%	Explore
intestine	10 studies	27% ± 9%	Explore
kidney	8 studies	32% ± 15%	Explore
eye	8 studies	42% ± 17%	Explore
bone marrow	5 studies	31% ± 12%	Explore
pancreas	4 studies	43% ± 19%	Explore
placenta	4 studies	42% ± 21%	Explore
uterus	4 studies	52% ± 7%	Explore
lymph node	4 studies	44% ± 9%	Explore
breast	4 studies	34% ± 9%	Explore
liver	4 studies	45% ± 16%	Explore
heart	3 studies	21% ± 5%	Explore
adipose	3 studies	27% ± 14%	Explore
adrenal gland	3 studies	30% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	100%	6457.93	966 / 966	100%	150.40	526 / 527
ovary	100%	4466.00	180 / 180	100%	153.21	429 / 430
thymus	100%	5219.80	652 / 653	100%	248.55	604 / 605
brain	100%	6720.09	2633 / 2642	100%	227.38	705 / 705
breast	100%	8144.17	459 / 459	100%	263.04	1114 / 1118
prostate	100%	6008.81	244 / 245	100%	296.30	502 / 502
lung	100%	7875.64	577 / 578	100%	189.69	1151 / 1155
adrenal gland	100%	9740.87	258 / 258	99%	223.18	228 / 230
uterus	100%	6287.14	170 / 170	99%	137.70	455 / 459
stomach	99%	4572.57	357 / 359	100%	149.12	285 / 286
bladder	100%	6858.38	21 / 21	99%	154.43	497 / 504
kidney	98%	3821.75	87 / 89	100%	253.79	899 / 901
esophagus	100%	6024.98	1444 / 1445	97%	99.25	178 / 183
skin	99%	5525.06	1786 / 1809	97%	225.98	458 / 472
pancreas	91%	2483.79	299 / 328	99%	202.15	177 / 178
liver	75%	1544.99	169 / 226	86%	66.67	348 / 406
adipose	100%	9095.23	1204 / 1204	0%	0	0 / 0
blood vessel	100%	12710.55	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	229.38	29 / 29
spleen	100%	5572.85	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	130.40	45 / 45
ureter	0%	0	0 / 0	100%	83.36	1 / 1
muscle	100%	8871.01	802 / 803	0%	0	0 / 0
heart	97%	8579.53	833 / 861	0%	0	0 / 0
peripheral blood	95%	6926.83	885 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	83%	82.82	66 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0072659	Biological process	protein localization to plasma membrane
GO_0032874	Biological process	positive regulation of stress-activated MAPK cascade
GO_0007611	Biological process	learning or memory
GO_0015813	Biological process	L-glutamate transmembrane transport
GO_0098712	Biological process	L-glutamate import across plasma membrane
GO_0043280	Biological process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0051051	Biological process	negative regulation of transport
GO_0034599	Biological process	cellular response to oxidative stress
GO_0010917	Biological process	negative regulation of mitochondrial membrane potential
GO_0015031	Biological process	protein transport
GO_0008631	Biological process	intrinsic apoptotic signaling pathway in response to oxidative stress
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0071407	Biological process	cellular response to organic cyclic compound
GO_0006749	Biological process	glutathione metabolic process
GO_0002037	Biological process	negative regulation of L-glutamate import across plasma membrane
GO_0005856	Cellular component	cytoskeleton
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0099523	Cellular component	presynaptic cytosol
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

IV. Literature review

[source]

Gene name	ARL6IP5
Protein name	PRA1 family protein PRA1 family protein 3 (ADP-ribosylation factor-like protein 6-interacting protein 5) (ARL-6-interacting protein 5) (Aip-5) (Cytoskeleton-related vitamin A-responsive protein) (Dermal papilla-derived protein 11) (GTRAP3-18) (Glutamate transporter EAAC1-interacting protein) (JM5) (Prenylated Rab acceptor protein 2) (Protein JWa) (Putative MAPK-activating protein PM27)
Synonyms	HSPC127 PRA2 JWA DERP11 PRAF3
Description	FUNCTION: Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum. .
Accessions	ENST00000484921.1 F8WF33 F8WF90 C9JQU6 O75915 ENST00000485444.1 ENST00000273258.4 ENST00000478935.1

ARL6IP5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review