ADD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051495Biological processpositive regulation of cytoskeleton organization
GO_0045907Biological processpositive regulation of vasoconstriction
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0007010Biological processcytoskeleton organization
GO_0051016Biological processbarbed-end actin filament capping
GO_0005911Cellular componentcell-cell junction
GO_0005903Cellular componentbrush border
GO_0000794Cellular componentcondensed nuclear chromosome
GO_0005856Cellular componentcytoskeleton
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0005886Cellular componentplasma membrane
GO_0014069Cellular componentpostsynaptic density
GO_0016020Cellular componentmembrane
GO_0005080Molecular functionprotein kinase C binding
GO_0005200Molecular functionstructural constituent of cytoskeleton
GO_0051015Molecular functionactin filament binding
GO_0005516Molecular functioncalmodulin binding

IV. Literature review

[source]
Gene nameADD3
Protein nameAdducin 3 (Gamma), isoform CRA_a (cDNA FLJ77558, highly similar to Homo sapiens adducin 3 (gamma) (ADD3), transcript variant 1, mRNA)
Gamma-adducin (Adducin-like protein 70)
SynonymsADDL
hCG_1789399
DescriptionFUNCTION: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping . Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). .

AccessionsQ5VU08
ENST00000356080.9 [Q9UEY8-1]
ENST00000277900.12 [Q9UEY8-2]
ENST00000360162.7 [Q9UEY8-2]
Q9UEY8