ACADVL | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	36 studies	28% ± 13%	Explore
macrophage	30 studies	28% ± 9%	Explore
endothelial cell	29 studies	27% ± 10%	Explore
pericyte	25 studies	29% ± 7%	Explore
smooth muscle cell	24 studies	28% ± 10%	Explore
natural killer cell	22 studies	24% ± 5%	Explore
epithelial cell	20 studies	41% ± 18%	Explore
basal cell	19 studies	40% ± 16%	Explore
classical monocyte	18 studies	27% ± 10%	Explore
non-classical monocyte	16 studies	24% ± 9%	Explore
CD8-positive, alpha-beta T cell	16 studies	24% ± 7%	Explore
conventional dendritic cell	15 studies	30% ± 16%	Explore
regulatory T cell	15 studies	23% ± 9%	Explore
mast cell	14 studies	22% ± 5%	Explore
monocyte	14 studies	26% ± 9%	Explore
plasma cell	14 studies	39% ± 16%	Explore
ciliated cell	14 studies	39% ± 15%	Explore
T cell	13 studies	21% ± 6%	Explore
plasmacytoid dendritic cell	13 studies	32% ± 11%	Explore
astrocyte	13 studies	34% ± 15%	Explore
dendritic cell	12 studies	35% ± 16%	Explore
myofibroblast cell	12 studies	30% ± 10%	Explore
gamma-delta T cell	12 studies	25% ± 10%	Explore
myeloid cell	12 studies	25% ± 8%	Explore
type I pneumocyte	11 studies	30% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	26% ± 3%	Explore
B cell	11 studies	21% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	22% ± 3%	Explore
CD4-positive, alpha-beta T cell	11 studies	25% ± 11%	Explore
capillary endothelial cell	11 studies	20% ± 4%	Explore
connective tissue cell	11 studies	27% ± 8%	Explore
plasmablast	10 studies	38% ± 23%	Explore
secretory cell	10 studies	39% ± 14%	Explore
mature NK T cell	10 studies	21% ± 3%	Explore
adipocyte	10 studies	40% ± 21%	Explore
endothelial cell of lymphatic vessel	9 studies	26% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	22% ± 6%	Explore
club cell	9 studies	33% ± 15%	Explore
endothelial cell of artery	9 studies	21% ± 5%	Explore
type II pneumocyte	9 studies	29% ± 13%	Explore
alveolar macrophage	8 studies	28% ± 8%	Explore
goblet cell	8 studies	36% ± 14%	Explore
endothelial cell of vascular tree	8 studies	24% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	25% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	22% ± 6%	Explore
progenitor cell	7 studies	31% ± 11%	Explore
enterocyte	7 studies	41% ± 13%	Explore
abnormal cell	7 studies	36% ± 18%	Explore
mucosal invariant T cell	7 studies	23% ± 3%	Explore
hematopoietic precursor cell	6 studies	29% ± 11%	Explore
respiratory goblet cell	6 studies	35% ± 21%	Explore
epithelial cell of proximal tubule	6 studies	32% ± 6%	Explore
renal alpha-intercalated cell	6 studies	46% ± 10%	Explore
IgA plasma cell	6 studies	28% ± 6%	Explore
IgG plasma cell	6 studies	25% ± 6%	Explore
transit amplifying cell	6 studies	34% ± 14%	Explore
glutamatergic neuron	6 studies	31% ± 17%	Explore
memory B cell	6 studies	17% ± 1%	Explore
vein endothelial cell	6 studies	20% ± 4%	Explore
ionocyte	5 studies	37% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	23% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	17% ± 1%	Explore
kidney loop of Henle epithelial cell	5 studies	41% ± 12%	Explore
naive B cell	5 studies	19% ± 3%	Explore
innate lymphoid cell	5 studies	23% ± 4%	Explore
cardiac muscle cell	5 studies	38% ± 11%	Explore
T follicular helper cell	5 studies	17% ± 1%	Explore
hepatocyte	5 studies	60% ± 18%	Explore
deuterosomal cell	4 studies	52% ± 6%	Explore
duct epithelial cell	4 studies	25% ± 5%	Explore
squamous epithelial cell	4 studies	43% ± 18%	Explore
pancreatic A cell	4 studies	48% ± 20%	Explore
mononuclear phagocyte	4 studies	29% ± 13%	Explore
exhausted T cell	4 studies	29% ± 6%	Explore
neuron	4 studies	29% ± 11%	Explore
enteroendocrine cell	4 studies	36% ± 14%	Explore
intestinal crypt stem cell	4 studies	35% ± 10%	Explore
leukocyte	4 studies	24% ± 7%	Explore
erythroblast	4 studies	31% ± 10%	Explore
hematopoietic stem cell	4 studies	21% ± 2%	Explore
adventitial cell	4 studies	30% ± 10%	Explore
mesothelial cell	4 studies	30% ± 14%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	55% ± 11%	Explore
luminal cell of prostate epithelium	4 studies	45% ± 9%	Explore
hillock cell	3 studies	29% ± 9%	Explore
type B pancreatic cell	3 studies	47% ± 9%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	45% ± 18%	Explore
microglial cell	3 studies	19% ± 1%	Explore
renal principal cell	3 studies	61% ± 6%	Explore
extravillous trophoblast	3 studies	25% ± 5%	Explore
placental villous trophoblast	3 studies	81% ± 11%	Explore
common myeloid progenitor	3 studies	30% ± 14%	Explore
lymphocyte	3 studies	28% ± 3%	Explore
pro-B cell	3 studies	23% ± 3%	Explore
brush cell	3 studies	32% ± 9%	Explore
retinal pigment epithelial cell	3 studies	34% ± 23%	Explore
serous secreting cell	3 studies	25% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	34% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	29% ± 6%	Explore
intermediate monocyte	3 studies	37% ± 12%	Explore
muscle cell	3 studies	30% ± 16%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	29% ± 8%	Explore
pancreatic ductal cell	3 studies	68% ± 17%	Explore
granulocyte monocyte progenitor cell	3 studies	27% ± 10%	Explore
group 3 innate lymphoid cell	3 studies	29% ± 9%	Explore
keratinocyte	3 studies	23% ± 7%	Explore
T-helper 1 cell	3 studies	33% ± 18%	Explore
progenitor cell of mammary luminal epithelium	3 studies	41% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	32% ± 12%	Explore
peripheral blood	12 studies	24% ± 7%	Explore
intestine	11 studies	25% ± 11%	Explore
kidney	8 studies	28% ± 6%	Explore
brain	8 studies	26% ± 12%	Explore
heart	5 studies	21% ± 3%	Explore
breast	5 studies	27% ± 9%	Explore
liver	5 studies	33% ± 9%	Explore
pancreas	4 studies	46% ± 19%	Explore
placenta	4 studies	38% ± 15%	Explore
prostate	4 studies	34% ± 13%	Explore
bone marrow	3 studies	21% ± 3%	Explore
eye	3 studies	24% ± 4%	Explore
uterus	3 studies	31% ± 17%	Explore
esophagus	3 studies	40% ± 22%	Explore
skin	3 studies	18% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	57726.12	226 / 226	100%	269.02	406 / 406
pancreas	100%	33883.52	328 / 328	100%	200.17	178 / 178
thymus	100%	42773.36	653 / 653	100%	282.60	605 / 605
uterus	100%	24035.35	170 / 170	100%	192.45	459 / 459
prostate	100%	36028.45	245 / 245	100%	209.61	501 / 502
kidney	100%	41693.89	89 / 89	100%	299.85	898 / 901
intestine	100%	30992.62	966 / 966	100%	161.26	525 / 527
adrenal gland	100%	73601.80	258 / 258	100%	202.96	229 / 230
lung	100%	25788.02	576 / 578	100%	144.60	1152 / 1155
stomach	100%	28814.94	359 / 359	99%	131.13	284 / 286
breast	100%	32043.18	459 / 459	99%	148.74	1108 / 1118
bladder	100%	28461.29	21 / 21	99%	207.30	499 / 504
esophagus	100%	27417.55	1444 / 1445	99%	107.89	181 / 183
ovary	100%	22558.39	180 / 180	98%	97.57	423 / 430
skin	99%	19478.20	1784 / 1809	100%	149.73	470 / 472
brain	97%	12816.28	2559 / 2642	100%	149.41	705 / 705
adipose	100%	28701.92	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	127.59	29 / 29
muscle	100%	54440.80	803 / 803	0%	0	0 / 0
spleen	100%	30997.80	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	179.64	45 / 45
ureter	0%	0	0 / 0	100%	95.78	1 / 1
blood vessel	99%	16510.35	1328 / 1335	0%	0	0 / 0
heart	98%	45201.09	848 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	98%	140.51	78 / 80
peripheral blood	88%	10268.27	815 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0090181	Biological process	regulation of cholesterol metabolic process
GO_0015980	Biological process	energy derivation by oxidation of organic compounds
GO_0030855	Biological process	epithelial cell differentiation
GO_0009409	Biological process	response to cold
GO_0046322	Biological process	negative regulation of fatty acid oxidation
GO_0045717	Biological process	negative regulation of fatty acid biosynthetic process
GO_0033539	Biological process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO_0001659	Biological process	temperature homeostasis
GO_0005730	Cellular component	nucleolus
GO_0042645	Cellular component	mitochondrial nucleoid
GO_0005739	Cellular component	mitochondrion
GO_0031966	Cellular component	mitochondrial membrane
GO_0005654	Cellular component	nucleoplasm
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005759	Cellular component	mitochondrial matrix
GO_0017099	Molecular function	very-long-chain fatty acyl-CoA dehydrogenase activity
GO_0050660	Molecular function	flavin adenine dinucleotide binding
GO_0042802	Molecular function	identical protein binding
GO_0004466	Molecular function	long-chain fatty acyl-CoA dehydrogenase activity
GO_0003995	Molecular function	acyl-CoA dehydrogenase activity
GO_0000062	Molecular function	fatty-acyl-CoA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ACADVL
Protein name	Acyl-CoA dehydrogenase very long chain Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (EC 1.3.8.9) VLCAD (EC 1.3.8.8) Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9)
Synonyms	VLCAD hCG_42007
Description	FUNCTION: Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats . The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA . Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains . .
Accessions	J3QRJ8 J3KS89 ENST00000583312.5 A0A077H1I5 ENST00000350303.9 [P49748-2] ENST00000583858.5 ENST00000579546.1 ENST00000322910.9 K7EJW8 K7EMF8 ENST00000543245.6 [P49748-3] J3QKU9 J3KSR4 ENST00000579886.2 K7EQP4 ENST00000583848.5 ENST00000356839.10 [P49748-1] ENST00000584103.5 ENST00000542255.6 J9JID6 P49748 ENST00000581378.5 G3V1M7 B3KPA6

ACADVL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review