ZFAND5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	42 studies	37% ± 16%	Explore
endothelial cell	39 studies	39% ± 15%	Explore
macrophage	38 studies	43% ± 17%	Explore
pericyte	30 studies	44% ± 17%	Explore
smooth muscle cell	29 studies	38% ± 17%	Explore
classical monocyte	27 studies	48% ± 16%	Explore
conventional dendritic cell	27 studies	42% ± 16%	Explore
non-classical monocyte	25 studies	61% ± 17%	Explore
natural killer cell	24 studies	25% ± 8%	Explore
monocyte	23 studies	40% ± 17%	Explore
B cell	22 studies	23% ± 7%	Explore
dendritic cell	21 studies	49% ± 20%	Explore
basal cell	20 studies	37% ± 13%	Explore
epithelial cell	20 studies	40% ± 20%	Explore
CD4-positive, alpha-beta T cell	19 studies	23% ± 5%	Explore
regulatory T cell	19 studies	26% ± 7%	Explore
mast cell	17 studies	30% ± 10%	Explore
ciliated cell	17 studies	39% ± 16%	Explore
T cell	15 studies	28% ± 14%	Explore
astrocyte	15 studies	32% ± 11%	Explore
CD8-positive, alpha-beta T cell	15 studies	23% ± 4%	Explore
myofibroblast cell	15 studies	31% ± 11%	Explore
connective tissue cell	14 studies	34% ± 12%	Explore
capillary endothelial cell	13 studies	27% ± 11%	Explore
memory B cell	13 studies	23% ± 6%	Explore
endothelial cell of vascular tree	13 studies	48% ± 16%	Explore
naive B cell	12 studies	23% ± 6%	Explore
endothelial cell of artery	12 studies	31% ± 12%	Explore
myeloid cell	12 studies	46% ± 16%	Explore
type II pneumocyte	11 studies	35% ± 14%	Explore
secretory cell	11 studies	39% ± 12%	Explore
vein endothelial cell	11 studies	35% ± 15%	Explore
gamma-delta T cell	11 studies	27% ± 11%	Explore
type I pneumocyte	10 studies	36% ± 14%	Explore
glutamatergic neuron	10 studies	34% ± 20%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	26% ± 7%	Explore
mature NK T cell	10 studies	23% ± 5%	Explore
plasmacytoid dendritic cell	10 studies	26% ± 10%	Explore
endothelial cell of lymphatic vessel	9 studies	31% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	23% ± 9%	Explore
neutrophil	9 studies	23% ± 7%	Explore
mucosal invariant T cell	9 studies	25% ± 10%	Explore
alveolar macrophage	8 studies	41% ± 10%	Explore
club cell	8 studies	31% ± 16%	Explore
leukocyte	8 studies	34% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	29% ± 8%	Explore
kidney loop of Henle epithelial cell	8 studies	35% ± 12%	Explore
adipocyte	8 studies	36% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	28% ± 9%	Explore
oligodendrocyte	8 studies	24% ± 7%	Explore
epithelial cell of proximal tubule	7 studies	24% ± 6%	Explore
abnormal cell	7 studies	37% ± 20%	Explore
neuron	7 studies	37% ± 17%	Explore
innate lymphoid cell	7 studies	31% ± 12%	Explore
plasma cell	6 studies	31% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	21% ± 4%	Explore
mononuclear phagocyte	6 studies	50% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	26% ± 5%	Explore
goblet cell	6 studies	25% ± 7%	Explore
T follicular helper cell	6 studies	30% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	22% ± 4%	Explore
microglial cell	5 studies	24% ± 8%	Explore
adventitial cell	5 studies	32% ± 16%	Explore
hepatocyte	5 studies	61% ± 25%	Explore
GABAergic neuron	5 studies	37% ± 13%	Explore
erythrocyte	5 studies	24% ± 8%	Explore
oligodendrocyte precursor cell	5 studies	30% ± 10%	Explore
ionocyte	4 studies	41% ± 6%	Explore
respiratory goblet cell	4 studies	34% ± 13%	Explore
squamous epithelial cell	4 studies	54% ± 16%	Explore
pancreatic A cell	4 studies	52% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	21% ± 4%	Explore
hematopoietic precursor cell	4 studies	26% ± 13%	Explore
glomerular endothelial cell	4 studies	41% ± 11%	Explore
retinal ganglion cell	4 studies	57% ± 29%	Explore
lymphocyte	4 studies	34% ± 15%	Explore
brush cell	4 studies	26% ± 12%	Explore
retinal pigment epithelial cell	4 studies	49% ± 16%	Explore
glial cell	4 studies	33% ± 13%	Explore
mesothelial cell	4 studies	37% ± 17%	Explore
Mueller cell	4 studies	29% ± 5%	Explore
inflammatory macrophage	4 studies	37% ± 9%	Explore
intermediate monocyte	4 studies	55% ± 22%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	53% ± 8%	Explore
granulocyte	4 studies	27% ± 4%	Explore
melanocyte	4 studies	47% ± 14%	Explore
interneuron	4 studies	32% ± 17%	Explore
pancreatic D cell	3 studies	42% ± 26%	Explore
type B pancreatic cell	3 studies	60% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	27% ± 10%	Explore
monocyte-derived dendritic cell	3 studies	51% ± 20%	Explore
plasmablast	3 studies	38% ± 15%	Explore
podocyte	3 studies	30% ± 5%	Explore
progenitor cell	3 studies	27% ± 8%	Explore
renal alpha-intercalated cell	3 studies	39% ± 18%	Explore
retinal bipolar neuron	3 studies	34% ± 10%	Explore
renal principal cell	3 studies	44% ± 16%	Explore
extravillous trophoblast	3 studies	21% ± 1%	Explore
placental villous trophoblast	3 studies	33% ± 5%	Explore
pro-B cell	3 studies	23% ± 6%	Explore
retina horizontal cell	3 studies	27% ± 8%	Explore
tissue-resident macrophage	3 studies	47% ± 18%	Explore
OFF-bipolar cell	3 studies	30% ± 7%	Explore
ON-bipolar cell	3 studies	32% ± 8%	Explore
rod bipolar cell	3 studies	20% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	30% ± 6%	Explore
luminal cell of prostate epithelium	3 studies	38% ± 8%	Explore
muscle cell	3 studies	50% ± 3%	Explore
acinar cell	3 studies	58% ± 31%	Explore
pancreatic ductal cell	3 studies	60% ± 26%	Explore
enteroendocrine cell	3 studies	34% ± 11%	Explore
intestinal crypt stem cell	3 studies	18% ± 4%	Explore
group 3 innate lymphoid cell	3 studies	47% ± 16%	Explore
T-helper 1 cell	3 studies	30% ± 4%	Explore
myoepithelial cell	3 studies	46% ± 12%	Explore
progenitor cell of mammary luminal epithelium	3 studies	42% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	33% ± 11%	Explore
peripheral blood	15 studies	29% ± 10%	Explore
brain	15 studies	29% ± 15%	Explore
kidney	11 studies	25% ± 12%	Explore
intestine	9 studies	28% ± 13%	Explore
eye	7 studies	33% ± 15%	Explore
liver	6 studies	29% ± 7%	Explore
uterus	5 studies	47% ± 14%	Explore
pancreas	4 studies	51% ± 23%	Explore
placenta	4 studies	27% ± 8%	Explore
bone marrow	4 studies	24% ± 5%	Explore
breast	4 studies	42% ± 5%	Explore
adipose	3 studies	24% ± 6%	Explore
thymus	3 studies	25% ± 10%	Explore
lymph node	3 studies	41% ± 19%	Explore
prostate	3 studies	49% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	21310.93	258 / 258	100%	92.50	230 / 230
ovary	100%	46237.07	180 / 180	100%	69.86	430 / 430
kidney	100%	11233.93	89 / 89	100%	87.24	900 / 901
breast	100%	29324.20	459 / 459	100%	72.80	1116 / 1118
bladder	100%	20254.48	21 / 21	100%	67.03	503 / 504
esophagus	100%	18253.41	1440 / 1445	100%	86.53	183 / 183
lung	99%	23522.70	575 / 578	100%	83.20	1155 / 1155
uterus	100%	16116.32	170 / 170	99%	72.90	456 / 459
thymus	100%	16930.10	651 / 653	100%	79.99	602 / 605
prostate	99%	13759.73	242 / 245	100%	68.42	500 / 502
intestine	99%	14000.54	960 / 966	99%	58.58	521 / 527
skin	98%	12032.04	1778 / 1809	100%	71.32	470 / 472
stomach	97%	14346.87	350 / 359	100%	60.86	286 / 286
brain	96%	12936.15	2541 / 2642	100%	110.27	705 / 705
liver	92%	12708.16	208 / 226	98%	74.20	398 / 406
pancreas	74%	6138.98	242 / 328	98%	70.71	175 / 178
blood vessel	100%	36528.24	1335 / 1335	0%	0	0 / 0
muscle	100%	52108.37	803 / 803	0%	0	0 / 0
spleen	100%	10758.52	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	66.07	45 / 45
ureter	0%	0	0 / 0	100%	33.48	1 / 1
adipose	100%	33683.64	1203 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	98%	77.25	78 / 80
lymph node	0%	0	0 / 0	93%	39.58	27 / 29
heart	89%	10160.72	769 / 861	0%	0	0 / 0
peripheral blood	66%	5223.85	616 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0048008	Biological process	platelet-derived growth factor receptor signaling pathway
GO_0010761	Biological process	fibroblast migration
GO_0001944	Biological process	vasculature development
GO_0060324	Biological process	face development
GO_0001701	Biological process	in utero embryonic development
GO_0003016	Biological process	respiratory system process
GO_0008150	Biological process	biological_process
GO_0048745	Biological process	smooth muscle tissue development
GO_0048705	Biological process	skeletal system morphogenesis
GO_0005575	Cellular component	cellular_component
GO_0005737	Cellular component	cytoplasm
GO_0003677	Molecular function	DNA binding
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0003674	Molecular function	molecular_function

IV. Literature review

[source]

Gene name	ZFAND5
Protein name	AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216) Zinc finger AN1-type containing 5
Synonyms	ZNF216 ZA20D2
Description	FUNCTION: Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. .
Accessions	ENST00000376960.8 ENST00000237937.7 Q5QPB1 O76080 ENST00000343431.6 ENST00000376956.3 ENST00000376962.10

ZFAND5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review