WTAP | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	41 studies	32% ± 15%	Explore
endothelial cell	36 studies	30% ± 13%	Explore
B cell	32 studies	27% ± 10%	Explore
natural killer cell	32 studies	25% ± 7%	Explore
macrophage	30 studies	27% ± 11%	Explore
T cell	27 studies	24% ± 8%	Explore
smooth muscle cell	27 studies	22% ± 5%	Explore
pericyte	24 studies	29% ± 12%	Explore
CD4-positive, alpha-beta T cell	23 studies	24% ± 8%	Explore
CD8-positive, alpha-beta T cell	22 studies	23% ± 8%	Explore
conventional dendritic cell	20 studies	24% ± 12%	Explore
regulatory T cell	19 studies	23% ± 7%	Explore
monocyte	18 studies	30% ± 9%	Explore
classical monocyte	18 studies	33% ± 15%	Explore
naive B cell	16 studies	24% ± 6%	Explore
memory B cell	16 studies	24% ± 6%	Explore
non-classical monocyte	15 studies	33% ± 14%	Explore
endothelial cell of lymphatic vessel	14 studies	26% ± 9%	Explore
gamma-delta T cell	14 studies	27% ± 11%	Explore
basal cell	14 studies	33% ± 16%	Explore
mast cell	13 studies	26% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	25% ± 8%	Explore
mature NK T cell	13 studies	24% ± 7%	Explore
endothelial cell of vascular tree	13 studies	34% ± 13%	Explore
dendritic cell	12 studies	33% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	26% ± 8%	Explore
epithelial cell	12 studies	36% ± 22%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	24% ± 7%	Explore
connective tissue cell	11 studies	30% ± 10%	Explore
astrocyte	11 studies	26% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	25% ± 8%	Explore
mucosal invariant T cell	10 studies	22% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	28% ± 8%	Explore
leukocyte	9 studies	28% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	26% ± 12%	Explore
myofibroblast cell	9 studies	26% ± 9%	Explore
endothelial cell of artery	9 studies	21% ± 7%	Explore
vein endothelial cell	9 studies	29% ± 15%	Explore
plasmacytoid dendritic cell	9 studies	22% ± 8%	Explore
myeloid cell	9 studies	33% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	23% ± 7%	Explore
mesothelial cell	7 studies	26% ± 13%	Explore
microglial cell	7 studies	23% ± 8%	Explore
capillary endothelial cell	7 studies	22% ± 9%	Explore
secretory cell	7 studies	27% ± 10%	Explore
T follicular helper cell	7 studies	26% ± 7%	Explore
neutrophil	6 studies	23% ± 5%	Explore
mononuclear phagocyte	6 studies	38% ± 8%	Explore
lymphocyte	6 studies	30% ± 12%	Explore
innate lymphoid cell	6 studies	34% ± 12%	Explore
ciliated cell	6 studies	39% ± 13%	Explore
oligodendrocyte	6 studies	26% ± 7%	Explore
hematopoietic precursor cell	5 studies	33% ± 18%	Explore
precursor B cell	5 studies	33% ± 11%	Explore
pro-B cell	5 studies	34% ± 5%	Explore
plasma cell	5 studies	29% ± 14%	Explore
adipocyte	5 studies	22% ± 4%	Explore
neuron	5 studies	33% ± 15%	Explore
type II pneumocyte	5 studies	25% ± 8%	Explore
GABAergic neuron	5 studies	34% ± 14%	Explore
oligodendrocyte precursor cell	5 studies	29% ± 9%	Explore
pancreatic A cell	4 studies	25% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	22% ± 5%	Explore
progenitor cell	4 studies	17% ± 1%	Explore
club cell	4 studies	28% ± 13%	Explore
immature B cell	4 studies	27% ± 8%	Explore
Mueller cell	4 studies	19% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	34% ± 13%	Explore
granulocyte	4 studies	25% ± 6%	Explore
luminal cell of prostate epithelium	4 studies	33% ± 7%	Explore
glutamatergic neuron	4 studies	48% ± 17%	Explore
abnormal cell	4 studies	30% ± 10%	Explore
goblet cell	4 studies	35% ± 18%	Explore
transit amplifying cell	4 studies	29% ± 17%	Explore
keratinocyte	4 studies	35% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	25% ± 6%	Explore
exhausted T cell	3 studies	30% ± 14%	Explore
plasmablast	3 studies	41% ± 16%	Explore
neural crest cell	3 studies	23% ± 4%	Explore
hematopoietic stem cell	3 studies	20% ± 3%	Explore
retinal cone cell	3 studies	23% ± 3%	Explore
retinal pigment epithelial cell	3 studies	41% ± 12%	Explore
tissue-resident macrophage	3 studies	30% ± 3%	Explore
inflammatory macrophage	3 studies	37% ± 25%	Explore
germinal center B cell	3 studies	26% ± 2%	Explore
CD4-positive helper T cell	3 studies	30% ± 11%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	28% ± 4%	Explore
monocyte-derived dendritic cell	3 studies	24% ± 6%	Explore
muscle cell	3 studies	35% ± 6%	Explore
type I pneumocyte	3 studies	31% ± 6%	Explore
intestinal crypt stem cell	3 studies	21% ± 2%	Explore
adventitial cell	3 studies	31% ± 10%	Explore
group 3 innate lymphoid cell	3 studies	39% ± 11%	Explore
T-helper 17 cell	3 studies	27% ± 7%	Explore
interneuron	3 studies	37% ± 19%	Explore
progenitor cell of mammary luminal epithelium	3 studies	27% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	29% ± 11%	Explore
lung	12 studies	30% ± 12%	Explore
intestine	7 studies	23% ± 10%	Explore
brain	7 studies	35% ± 13%	Explore
kidney	6 studies	18% ± 2%	Explore
eye	5 studies	30% ± 15%	Explore
uterus	5 studies	32% ± 10%	Explore
pancreas	4 studies	27% ± 8%	Explore
bone marrow	4 studies	21% ± 4%	Explore
breast	4 studies	30% ± 10%	Explore
prostate	4 studies	26% ± 6%	Explore
liver	4 studies	33% ± 14%	Explore
adipose	4 studies	20% ± 3%	Explore
heart	3 studies	16% ± 1%	Explore
placenta	3 studies	25% ± 9%	Explore
skin	3 studies	39% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	4979.29	21 / 21	100%	36.85	504 / 504
breast	100%	6213.74	459 / 459	100%	42.29	1118 / 1118
esophagus	100%	4392.91	1445 / 1445	100%	34.82	183 / 183
intestine	100%	4546.41	966 / 966	100%	33.45	527 / 527
lung	100%	5745.52	578 / 578	100%	40.83	1155 / 1155
ovary	100%	5379.61	180 / 180	100%	30.09	430 / 430
pancreas	100%	2841.82	328 / 328	100%	33.24	178 / 178
prostate	100%	5885.54	245 / 245	100%	54.32	502 / 502
stomach	100%	3687.03	359 / 359	100%	30.74	286 / 286
uterus	100%	5548.21	170 / 170	100%	46.02	459 / 459
thymus	100%	5350.55	653 / 653	100%	42.06	604 / 605
adrenal gland	100%	4967.01	258 / 258	100%	27.34	229 / 230
kidney	100%	4125.39	89 / 89	99%	33.12	896 / 901
brain	99%	2812.15	2623 / 2642	100%	45.45	705 / 705
liver	100%	2306.54	226 / 226	98%	18.04	398 / 406
skin	100%	5684.84	1809 / 1809	97%	25.62	457 / 472
adipose	100%	6514.82	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4683.76	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	47.40	29 / 29
muscle	100%	7032.60	803 / 803	0%	0	0 / 0
spleen	100%	5696.29	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	44.95	45 / 45
ureter	0%	0	0 / 0	100%	15.67	1 / 1
peripheral blood	98%	4010.04	910 / 929	0%	0	0 / 0
heart	98%	2738.05	841 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	88%	16.88	70 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0008380	Biological process	RNA splicing
GO_0006397	Biological process	mRNA processing
GO_0000381	Biological process	regulation of alternative mRNA splicing, via spliceosome
GO_0016556	Biological process	mRNA modification
GO_0016607	Cellular component	nuclear speck
GO_0005654	Cellular component	nucleoplasm
GO_0036396	Cellular component	RNA N6-methyladenosine methyltransferase complex
GO_0031965	Cellular component	nuclear membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	WTAP
Protein name	Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (WT1-associated protein) (Wilms tumor 1-associating protein) Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein)
Synonyms	hCG_34028 KIAA0105
Description	FUNCTION: Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing . Required for accumulation of METTL3 and METTL14 to nuclear speckle . Acts as a mRNA splicing regulator . Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability . Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes . .
Accessions	ENST00000358372.8 [Q15007-1] ENST00000337387.4 [Q15007-2] ENST00000650096.1 [Q15007-2] ENST00000614346.4 A0A087X1R4 ENST00000621533.5 [Q15007-1] Q15007 ENST00000631126.2

WTAP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review