WBP2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	22 studies	22% ± 8%	Explore
macrophage	17 studies	21% ± 8%	Explore
B cell	15 studies	22% ± 4%	Explore
regulatory T cell	15 studies	23% ± 4%	Explore
CD4-positive, alpha-beta T cell	14 studies	20% ± 3%	Explore
natural killer cell	13 studies	19% ± 4%	Explore
memory B cell	13 studies	22% ± 5%	Explore
non-classical monocyte	12 studies	26% ± 11%	Explore
classical monocyte	10 studies	24% ± 9%	Explore
astrocyte	10 studies	30% ± 11%	Explore
naive B cell	10 studies	21% ± 3%	Explore
ciliated cell	10 studies	25% ± 9%	Explore
gamma-delta T cell	10 studies	21% ± 5%	Explore
type I pneumocyte	9 studies	25% ± 9%	Explore
platelet	9 studies	45% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	20% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	19% ± 2%	Explore
capillary endothelial cell	9 studies	19% ± 4%	Explore
CD8-positive, alpha-beta T cell	9 studies	21% ± 3%	Explore
fibroblast	9 studies	23% ± 6%	Explore
endothelial cell of vascular tree	9 studies	22% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	21% ± 4%	Explore
oligodendrocyte	8 studies	24% ± 6%	Explore
mucosal invariant T cell	8 studies	21% ± 3%	Explore
mature NK T cell	7 studies	20% ± 4%	Explore
glutamatergic neuron	7 studies	33% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	21% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	21% ± 4%	Explore
erythrocyte	6 studies	30% ± 13%	Explore
epithelial cell	6 studies	37% ± 10%	Explore
T follicular helper cell	6 studies	21% ± 2%	Explore
abnormal cell	6 studies	31% ± 15%	Explore
basal cell	6 studies	27% ± 6%	Explore
neutrophil	5 studies	20% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	22% ± 4%	Explore
conventional dendritic cell	5 studies	32% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	23% ± 3%	Explore
neuron	5 studies	35% ± 11%	Explore
smooth muscle cell	5 studies	21% ± 3%	Explore
myeloid cell	5 studies	27% ± 9%	Explore
mast cell	5 studies	21% ± 5%	Explore
endothelial cell of lymphatic vessel	5 studies	23% ± 7%	Explore
retinal rod cell	5 studies	31% ± 14%	Explore
T cell	5 studies	18% ± 2%	Explore
monocyte	4 studies	20% ± 4%	Explore
kidney loop of Henle epithelial cell	4 studies	19% ± 5%	Explore
retinal ganglion cell	4 studies	80% ± 22%	Explore
pericyte	4 studies	18% ± 3%	Explore
type II pneumocyte	4 studies	26% ± 11%	Explore
amacrine cell	4 studies	43% ± 16%	Explore
retinal pigment epithelial cell	4 studies	44% ± 18%	Explore
endothelial cell of artery	4 studies	19% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	23% ± 3%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	18% ± 3%	Explore
GABAergic neuron	4 studies	37% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	22% ± 3%	Explore
secretory cell	4 studies	20% ± 6%	Explore
plasmacytoid dendritic cell	4 studies	22% ± 5%	Explore
squamous epithelial cell	3 studies	40% ± 24%	Explore
pancreatic A cell	3 studies	29% ± 9%	Explore
type B pancreatic cell	3 studies	40% ± 17%	Explore
glomerular endothelial cell	3 studies	20% ± 1%	Explore
retinal bipolar neuron	3 studies	43% ± 15%	Explore
OFF-bipolar cell	3 studies	48% ± 32%	Explore
ON-bipolar cell	3 studies	48% ± 33%	Explore
megakaryocyte	3 studies	41% ± 21%	Explore
plasma cell	3 studies	26% ± 7%	Explore
retina horizontal cell	3 studies	38% ± 10%	Explore
retinal cone cell	3 studies	45% ± 15%	Explore
Mueller cell	3 studies	27% ± 4%	Explore
exhausted T cell	3 studies	24% ± 4%	Explore
intermediate monocyte	3 studies	31% ± 11%	Explore
pancreatic ductal cell	3 studies	54% ± 25%	Explore
oligodendrocyte precursor cell	3 studies	41% ± 18%	Explore
goblet cell	3 studies	21% ± 4%	Explore
group 3 innate lymphoid cell	3 studies	23% ± 5%	Explore
innate lymphoid cell	3 studies	20% ± 2%	Explore
double negative thymocyte	3 studies	23% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	21% ± 5%	Explore
brain	12 studies	26% ± 10%	Explore
eye	8 studies	30% ± 11%	Explore
lung	7 studies	23% ± 7%	Explore
lymph node	4 studies	20% ± 4%	Explore
pancreas	3 studies	38% ± 12%	Explore
bone marrow	3 studies	15% ± 0%	Explore
intestine	3 studies	20% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	22585.84	2642 / 2642	100%	245.38	705 / 705
esophagus	100%	8952.19	1445 / 1445	100%	68.59	183 / 183
liver	100%	8941.04	226 / 226	100%	92.76	406 / 406
ovary	100%	10585.76	180 / 180	100%	94.80	430 / 430
uterus	100%	9461.46	170 / 170	100%	81.26	458 / 459
thymus	100%	9191.70	652 / 653	100%	132.59	604 / 605
prostate	100%	10760.76	245 / 245	100%	121.11	500 / 502
adrenal gland	100%	19883.72	258 / 258	100%	152.67	229 / 230
kidney	100%	10368.58	89 / 89	99%	104.09	896 / 901
pancreas	99%	7078.55	325 / 328	100%	84.60	178 / 178
skin	99%	9578.55	1792 / 1809	100%	137.12	472 / 472
intestine	100%	9074.99	966 / 966	99%	65.29	522 / 527
breast	100%	11455.11	459 / 459	99%	100.92	1102 / 1118
lung	100%	12013.04	577 / 578	99%	82.80	1139 / 1155
stomach	100%	9021.74	359 / 359	98%	63.69	281 / 286
bladder	100%	9336.43	21 / 21	98%	76.66	492 / 504
adipose	100%	10559.80	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	143.79	80 / 80
lymph node	0%	0	0 / 0	100%	84.53	29 / 29
peripheral blood	100%	17634.60	929 / 929	0%	0	0 / 0
spleen	100%	11276.88	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	73.93	45 / 45
ureter	0%	0	0 / 0	100%	60.79	1 / 1
blood vessel	100%	10573.89	1334 / 1335	0%	0	0 / 0
muscle	100%	13138.03	801 / 803	0%	0	0 / 0
heart	97%	9076.28	835 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043627	Biological process	response to estrogen
GO_0071169	Biological process	establishment of protein localization to chromatin
GO_0050847	Biological process	progesterone receptor signaling pathway
GO_0071391	Biological process	cellular response to estrogen stimulus
GO_0033148	Biological process	positive regulation of intracellular estrogen receptor signaling pathway
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0032570	Biological process	response to progesterone
GO_0045815	Biological process	transcription initiation-coupled chromatin remodeling
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0030331	Molecular function	nuclear estrogen receptor binding
GO_0031490	Molecular function	chromatin DNA binding
GO_0003713	Molecular function	transcription coactivator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	WBP2
Protein name	WW domain binding protein 2 WW domain binding protein 2 (cDNA FLJ59459, highly similar to WW domain-binding protein 2) WW domain-binding protein 2 (WBP-2) Alternative protein WBP2
Synonyms
Description	FUNCTION: Acts as a transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation . In presence of estrogen, binds to ESR1-responsive promoters . Required for YAP1 coactivation function on PGR activity . Synergizes with WBP2 in enhancing PGR activity . Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity). .
Accessions	ENST00000254806.8 [Q969T9-1] K7EIN1 ENST00000585462.5 ENST00000591831.5 ENST00000588373.5 ENST00000586257.5 K7ESN4 ENST00000590221.5 K7EJ75 ENST00000433525.6 [Q969T9-2] K7EIK1 ENST00000626827.2 ENST00000587374.5 Q969T9 A6NG10 ENST00000593002.1 ENST00000589642.5 K7ENL2 L0R5E7 K7EMC9 K7EIJ0 ENST00000591399.5 [Q969T9-1]

WBP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review