USP15 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0140673Biological processtranscription elongation-coupled chromatin remodeling
GO_0035520Biological processmonoubiquitinated protein deubiquitination
GO_1990167Biological processprotein K27-linked deubiquitination
GO_0030509Biological processBMP signaling pathway
GO_1900246Biological processpositive regulation of RIG-I signaling pathway
GO_0006508Biological processproteolysis
GO_1902238Biological processregulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
GO_0016579Biological processprotein deubiquitination
GO_1905035Biological processnegative regulation of antifungal innate immune response
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0101005Molecular functiondeubiquitinase activity
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0046332Molecular functionSMAD binding
GO_0042802Molecular functionidentical protein binding
GO_1990380Molecular functionK48-linked deubiquitinase activity
GO_0061649Molecular functionubiquitin-modified histone reader activity
GO_0005160Molecular functiontransforming growth factor beta receptor binding
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUSP15
Protein nameUbiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4)
ubiquitinyl hydrolase 1 (EC 3.4.19.12)
Ubiquitin specific peptidase 15
SynonymsKIAA0529
DescriptionFUNCTION: Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways . Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes . According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal . Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains . May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B . Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy . Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP . Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery . Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9 . .; FUNCTION: (Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. .

AccessionsF8VZG8
ENST00000549237.5
H0YI31
H0YH96
ENST00000312635.10 [Q9Y4E8-4]
H0YHM4
ENST00000546694.1
H0YI26
ENST00000548620.1
ENST00000549523.5
ENST00000353364.7 [Q9Y4E8-2]
F8VVY7
Q9Y4E8
ENST00000552997.1
ENST00000280377.10 [Q9Y4E8-1]
Q2NL66
F8W0H4
ENST00000548836.1
ENST00000549415.1