TMED9 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	35 studies	33% ± 10%	Explore
endothelial cell	34 studies	36% ± 16%	Explore
fibroblast	34 studies	40% ± 18%	Explore
macrophage	28 studies	33% ± 13%	Explore
CD8-positive, alpha-beta T cell	26 studies	28% ± 10%	Explore
T cell	23 studies	25% ± 7%	Explore
plasma cell	23 studies	57% ± 23%	Explore
B cell	23 studies	24% ± 7%	Explore
conventional dendritic cell	21 studies	33% ± 15%	Explore
CD4-positive, alpha-beta T cell	20 studies	28% ± 9%	Explore
epithelial cell	20 studies	40% ± 21%	Explore
pericyte	20 studies	35% ± 16%	Explore
basal cell	19 studies	37% ± 21%	Explore
regulatory T cell	19 studies	30% ± 8%	Explore
plasmacytoid dendritic cell	18 studies	46% ± 13%	Explore
smooth muscle cell	17 studies	30% ± 11%	Explore
connective tissue cell	17 studies	42% ± 18%	Explore
mature NK T cell	16 studies	28% ± 8%	Explore
classical monocyte	16 studies	27% ± 12%	Explore
non-classical monocyte	16 studies	29% ± 13%	Explore
naive B cell	15 studies	20% ± 5%	Explore
gamma-delta T cell	15 studies	31% ± 10%	Explore
mast cell	14 studies	24% ± 7%	Explore
endothelial cell of lymphatic vessel	14 studies	40% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	36% ± 9%	Explore
memory B cell	14 studies	21% ± 5%	Explore
plasmablast	12 studies	61% ± 22%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	28% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	20% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	33% ± 9%	Explore
capillary endothelial cell	12 studies	33% ± 10%	Explore
myofibroblast cell	12 studies	39% ± 10%	Explore
monocyte	12 studies	27% ± 12%	Explore
myeloid cell	12 studies	31% ± 13%	Explore
secretory cell	11 studies	35% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	25% ± 5%	Explore
endothelial cell of artery	11 studies	37% ± 12%	Explore
vein endothelial cell	11 studies	33% ± 12%	Explore
ciliated cell	11 studies	33% ± 15%	Explore
abnormal cell	10 studies	35% ± 18%	Explore
mucosal invariant T cell	10 studies	29% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	28% ± 10%	Explore
goblet cell	9 studies	38% ± 13%	Explore
IgG plasma cell	9 studies	40% ± 15%	Explore
dendritic cell	9 studies	39% ± 19%	Explore
endothelial cell of vascular tree	9 studies	31% ± 7%	Explore
type I pneumocyte	8 studies	35% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	28% ± 8%	Explore
progenitor cell	8 studies	39% ± 17%	Explore
IgA plasma cell	8 studies	40% ± 17%	Explore
alveolar macrophage	7 studies	23% ± 6%	Explore
club cell	7 studies	33% ± 16%	Explore
mesothelial cell	7 studies	46% ± 20%	Explore
innate lymphoid cell	7 studies	27% ± 6%	Explore
hematopoietic precursor cell	6 studies	41% ± 20%	Explore
respiratory goblet cell	6 studies	30% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	36% ± 12%	Explore
hematopoietic stem cell	6 studies	24% ± 9%	Explore
precursor B cell	6 studies	28% ± 9%	Explore
type II pneumocyte	6 studies	36% ± 19%	Explore
T follicular helper cell	6 studies	23% ± 2%	Explore
ionocyte	5 studies	25% ± 4%	Explore
leukocyte	5 studies	30% ± 6%	Explore
mononuclear phagocyte	5 studies	32% ± 19%	Explore
kidney loop of Henle epithelial cell	5 studies	26% ± 10%	Explore
transit amplifying cell	5 studies	21% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	33% ± 12%	Explore
neuron	5 studies	32% ± 13%	Explore
pancreatic A cell	4 studies	47% ± 21%	Explore
exhausted T cell	4 studies	36% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	44% ± 9%	Explore
enteroendocrine cell	4 studies	38% ± 15%	Explore
immature B cell	4 studies	23% ± 7%	Explore
astrocyte	4 studies	29% ± 14%	Explore
adventitial cell	4 studies	42% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	43% ± 11%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	38% ± 8%	Explore
luminal cell of prostate epithelium	4 studies	25% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	30% ± 6%	Explore
duct epithelial cell	3 studies	30% ± 6%	Explore
pancreatic D cell	3 studies	50% ± 19%	Explore
type B pancreatic cell	3 studies	51% ± 23%	Explore
glomerular endothelial cell	3 studies	32% ± 8%	Explore
podocyte	3 studies	62% ± 17%	Explore
renal alpha-intercalated cell	3 studies	36% ± 10%	Explore
enterocyte	3 studies	20% ± 3%	Explore
neural crest cell	3 studies	38% ± 4%	Explore
retinal bipolar neuron	3 studies	28% ± 8%	Explore
extravillous trophoblast	3 studies	92% ± 3%	Explore
placental villous trophoblast	3 studies	91% ± 2%	Explore
common myeloid progenitor	3 studies	38% ± 16%	Explore
lymphocyte	3 studies	34% ± 9%	Explore
squamous epithelial cell	3 studies	36% ± 25%	Explore
pro-B cell	3 studies	26% ± 4%	Explore
amacrine cell	3 studies	35% ± 12%	Explore
retina horizontal cell	3 studies	26% ± 13%	Explore
retinal cone cell	3 studies	37% ± 13%	Explore
microglial cell	3 studies	42% ± 11%	Explore
mucus secreting cell	3 studies	48% ± 14%	Explore
serous secreting cell	3 studies	35% ± 8%	Explore
intraepithelial lymphocyte	3 studies	28% ± 10%	Explore
Mueller cell	3 studies	30% ± 10%	Explore
CD4-positive helper T cell	3 studies	26% ± 2%	Explore
acinar cell	3 studies	38% ± 23%	Explore
erythroblast	3 studies	29% ± 17%	Explore
germinal center B cell	3 studies	20% ± 1%	Explore
intermediate monocyte	3 studies	37% ± 16%	Explore
myoepithelial cell	3 studies	45% ± 13%	Explore
IgM plasma cell	3 studies	49% ± 7%	Explore
glutamatergic neuron	3 studies	30% ± 4%	Explore
pancreatic ductal cell	3 studies	65% ± 4%	Explore
granulocyte monocyte progenitor cell	3 studies	50% ± 27%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	38% ± 27%	Explore
glial cell	3 studies	38% ± 21%	Explore
group 3 innate lymphoid cell	3 studies	38% ± 11%	Explore
T-helper 17 cell	3 studies	34% ± 10%	Explore
T-helper 1 cell	3 studies	35% ± 11%	Explore
double negative thymocyte	3 studies	39% ± 9%	Explore
progenitor cell of mammary luminal epithelium	3 studies	27% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	36% ± 15%	Explore
peripheral blood	14 studies	29% ± 6%	Explore
intestine	11 studies	29% ± 14%	Explore
kidney	8 studies	30% ± 11%	Explore
placenta	5 studies	54% ± 32%	Explore
bone marrow	5 studies	23% ± 5%	Explore
lymph node	5 studies	31% ± 17%	Explore
brain	5 studies	27% ± 11%	Explore
liver	5 studies	27% ± 14%	Explore
pancreas	4 studies	49% ± 19%	Explore
eye	4 studies	28% ± 11%	Explore
skin	4 studies	20% ± 4%	Explore
breast	4 studies	29% ± 4%	Explore
uterus	3 studies	43% ± 18%	Explore
adrenal gland	3 studies	24% ± 6%	Explore
prostate	3 studies	28% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	8342.62	226 / 226	100%	213.80	406 / 406
pancreas	100%	9218.35	328 / 328	100%	211.90	178 / 178
skin	100%	8574.63	1809 / 1809	100%	225.79	472 / 472
uterus	100%	5085.17	170 / 170	100%	222.15	459 / 459
esophagus	100%	5506.20	1444 / 1445	100%	85.69	183 / 183
kidney	100%	5895.40	89 / 89	100%	186.68	900 / 901
thymus	100%	6548.17	653 / 653	100%	170.08	603 / 605
prostate	100%	6292.94	245 / 245	100%	288.95	500 / 502
lung	100%	7285.56	578 / 578	100%	197.45	1150 / 1155
adrenal gland	100%	6931.67	258 / 258	100%	164.15	229 / 230
breast	100%	5337.44	459 / 459	99%	209.81	1111 / 1118
stomach	100%	5781.40	359 / 359	99%	142.75	284 / 286
ovary	100%	4194.48	180 / 180	99%	116.52	426 / 430
intestine	100%	5194.14	966 / 966	99%	188.68	522 / 527
bladder	100%	5943.71	21 / 21	99%	211.91	499 / 504
brain	99%	2795.60	2606 / 2642	100%	130.65	705 / 705
adipose	100%	5415.00	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	146.40	80 / 80
lymph node	0%	0	0 / 0	100%	184.80	29 / 29
spleen	100%	7069.62	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	193.57	45 / 45
ureter	0%	0	0 / 0	100%	105.99	1 / 1
blood vessel	100%	5560.71	1333 / 1335	0%	0	0 / 0
heart	99%	4090.91	853 / 861	0%	0	0 / 0
peripheral blood	98%	5402.75	914 / 929	0%	0	0 / 0
muscle	97%	2210.52	780 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0032527	Biological process	protein exit from endoplasmic reticulum
GO_0034498	Biological process	early endosome to Golgi transport
GO_0006886	Biological process	intracellular protein transport
GO_0007030	Biological process	Golgi organization
GO_0010638	Biological process	positive regulation of organelle organization
GO_0006888	Biological process	endoplasmic reticulum to Golgi vesicle-mediated transport
GO_0048205	Biological process	COPI coating of Golgi vesicle
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005794	Cellular component	Golgi apparatus
GO_0033116	Cellular component	endoplasmic reticulum-Golgi intermediate compartment membrane
GO_0000139	Cellular component	Golgi membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0008021	Cellular component	synaptic vesicle
GO_0030140	Cellular component	trans-Golgi network transport vesicle
GO_0005793	Cellular component	endoplasmic reticulum-Golgi intermediate compartment
GO_0030134	Cellular component	COPII-coated ER to Golgi transport vesicle
GO_0030133	Cellular component	transport vesicle
GO_0038024	Molecular function	cargo receptor activity
GO_0005515	Molecular function	protein binding
GO_0019905	Molecular function	syntaxin binding

IV. Literature review

[source]

Gene name	TMED9
Protein name	Transmembrane emp24 domain-containing protein 9 (GMP25) (Glycoprotein 25L2) (p24 family protein alpha-2) (p24alpha2) (p25)
Synonyms	GP25L2
Description	FUNCTION: Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. .
Accessions	ENST00000332598.7 Q9BVK6

TMED9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review