TMED4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	21 studies	23% ± 6%	Explore
fibroblast	19 studies	23% ± 8%	Explore
regulatory T cell	18 studies	22% ± 3%	Explore
CD4-positive, alpha-beta T cell	17 studies	23% ± 7%	Explore
CD8-positive, alpha-beta T cell	17 studies	24% ± 6%	Explore
B cell	14 studies	24% ± 6%	Explore
T cell	14 studies	21% ± 4%	Explore
smooth muscle cell	14 studies	25% ± 7%	Explore
ciliated cell	14 studies	36% ± 15%	Explore
epithelial cell	14 studies	35% ± 21%	Explore
pericyte	14 studies	24% ± 8%	Explore
naive B cell	12 studies	19% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	23% ± 6%	Explore
plasmacytoid dendritic cell	12 studies	30% ± 8%	Explore
gamma-delta T cell	12 studies	26% ± 9%	Explore
plasma cell	11 studies	37% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	26% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	25% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	26% ± 6%	Explore
memory B cell	11 studies	20% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	23% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	24% ± 5%	Explore
mature NK T cell	10 studies	23% ± 5%	Explore
myofibroblast cell	10 studies	26% ± 8%	Explore
connective tissue cell	9 studies	24% ± 8%	Explore
abnormal cell	9 studies	27% ± 11%	Explore
mucosal invariant T cell	9 studies	27% ± 5%	Explore
endothelial cell	8 studies	23% ± 7%	Explore
type I pneumocyte	7 studies	29% ± 12%	Explore
plasmablast	7 studies	38% ± 22%	Explore
basal cell	7 studies	34% ± 17%	Explore
secretory cell	6 studies	25% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	19% ± 3%	Explore
conventional dendritic cell	6 studies	27% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	31% ± 8%	Explore
epithelial cell of proximal tubule	6 studies	25% ± 8%	Explore
neuron	6 studies	30% ± 15%	Explore
enterocyte	6 studies	30% ± 3%	Explore
macrophage	6 studies	22% ± 7%	Explore
T follicular helper cell	6 studies	22% ± 4%	Explore
oligodendrocyte precursor cell	6 studies	25% ± 6%	Explore
classical monocyte	5 studies	24% ± 10%	Explore
non-classical monocyte	5 studies	28% ± 12%	Explore
IgA plasma cell	5 studies	19% ± 2%	Explore
amacrine cell	5 studies	31% ± 14%	Explore
mast cell	5 studies	23% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	27% ± 12%	Explore
innate lymphoid cell	5 studies	22% ± 6%	Explore
glutamatergic neuron	5 studies	32% ± 14%	Explore
hematopoietic precursor cell	4 studies	26% ± 15%	Explore
club cell	4 studies	30% ± 14%	Explore
pancreatic A cell	4 studies	38% ± 12%	Explore
leukocyte	4 studies	20% ± 1%	Explore
exhausted T cell	4 studies	27% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	29% ± 7%	Explore
mesothelial cell	4 studies	28% ± 16%	Explore
IgG plasma cell	4 studies	19% ± 1%	Explore
retina horizontal cell	4 studies	35% ± 11%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	23% ± 6%	Explore
enteroendocrine cell	4 studies	31% ± 18%	Explore
oligodendrocyte	4 studies	32% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	20% ± 3%	Explore
respiratory goblet cell	3 studies	32% ± 19%	Explore
type B pancreatic cell	3 studies	32% ± 11%	Explore
intestinal crypt stem cell	3 studies	21% ± 4%	Explore
neural crest cell	3 studies	21% ± 3%	Explore
progenitor cell	3 studies	32% ± 4%	Explore
retinal bipolar neuron	3 studies	44% ± 11%	Explore
placental villous trophoblast	3 studies	46% ± 16%	Explore
precursor B cell	3 studies	20% ± 2%	Explore
immature B cell	3 studies	22% ± 0%	Explore
type II pneumocyte	3 studies	35% ± 9%	Explore
astrocyte	3 studies	23% ± 9%	Explore
retinal cone cell	3 studies	48% ± 10%	Explore
retinal rod cell	3 studies	33% ± 8%	Explore
Mueller cell	3 studies	28% ± 10%	Explore
rod bipolar cell	3 studies	38% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	22% ± 4%	Explore
GABAergic neuron	3 studies	36% ± 6%	Explore
dendritic cell	3 studies	38% ± 17%	Explore
granulocyte	3 studies	17% ± 1%	Explore
goblet cell	3 studies	26% ± 9%	Explore
group 3 innate lymphoid cell	3 studies	31% ± 7%	Explore
transit amplifying cell	3 studies	18% ± 0%	Explore
interneuron	3 studies	33% ± 16%	Explore
T-helper 1 cell	3 studies	21% ± 4%	Explore
T-helper 17 cell	3 studies	19% ± 3%	Explore
double negative thymocyte	3 studies	33% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	24% ± 8%	Explore
lung	9 studies	29% ± 10%	Explore
brain	8 studies	26% ± 9%	Explore
intestine	7 studies	23% ± 8%	Explore
kidney	6 studies	21% ± 4%	Explore
eye	6 studies	27% ± 11%	Explore
lymph node	5 studies	21% ± 7%	Explore
uterus	4 studies	28% ± 14%	Explore
pancreas	3 studies	35% ± 11%	Explore
placenta	3 studies	23% ± 3%	Explore
bone marrow	3 studies	17% ± 1%	Explore
liver	3 studies	23% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	4795.19	459 / 459	100%	122.99	1118 / 1118
esophagus	100%	4372.24	1445 / 1445	100%	71.29	183 / 183
kidney	100%	6509.03	89 / 89	100%	145.17	901 / 901
lung	100%	5051.08	578 / 578	100%	116.71	1155 / 1155
ovary	100%	7345.57	180 / 180	100%	105.31	430 / 430
pancreas	100%	4337.09	328 / 328	100%	100.28	178 / 178
prostate	100%	5520.16	245 / 245	100%	160.91	502 / 502
stomach	100%	4697.14	359 / 359	100%	96.60	286 / 286
skin	100%	4480.38	1808 / 1809	100%	127.04	472 / 472
thymus	100%	10552.26	653 / 653	100%	226.03	604 / 605
bladder	100%	4771.90	21 / 21	100%	117.37	503 / 504
uterus	100%	6010.95	170 / 170	100%	93.33	458 / 459
liver	100%	2682.74	226 / 226	100%	62.17	405 / 406
brain	100%	3929.64	2634 / 2642	100%	109.03	705 / 705
intestine	100%	5644.62	966 / 966	100%	106.80	525 / 527
adrenal gland	100%	5624.35	258 / 258	99%	149.37	227 / 230
adipose	100%	4179.55	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	56.26	29 / 29
spleen	100%	4772.66	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	64.13	45 / 45
ureter	0%	0	0 / 0	100%	75.50	1 / 1
blood vessel	100%	6203.63	1334 / 1335	0%	0	0 / 0
muscle	100%	4033.32	802 / 803	0%	0	0 / 0
heart	99%	3672.88	850 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	98%	72.06	78 / 80
peripheral blood	95%	3046.49	886 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007030	Biological process	Golgi organization
GO_0006886	Biological process	intracellular protein transport
GO_0006888	Biological process	endoplasmic reticulum to Golgi vesicle-mediated transport
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005794	Cellular component	Golgi apparatus
GO_0030134	Cellular component	COPII-coated ER to Golgi transport vesicle
GO_0005793	Cellular component	endoplasmic reticulum-Golgi intermediate compartment
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0038024	Molecular function	cargo receptor activity

IV. Literature review

[source]

Gene name	TMED4
Protein name	Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25) (ERS25) (GMP25iso) (Putative NF-kappa-B-activating protein 156) (p24 family protein alpha-3) (p24alpha3) Transmembrane p24 trafficking protein 4
Synonyms	ERS25
Description	FUNCTION: Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity). .
Accessions	ENST00000289577.9 Q7Z7H5 F8W7F7 ENST00000457408.7 [Q7Z7H5-1] ENST00000481238.1 [Q7Z7H5-3]

TMED4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review