TKT | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	32 studies	46% ± 14%	Explore
B cell	29 studies	33% ± 15%	Explore
classical monocyte	28 studies	74% ± 16%	Explore
conventional dendritic cell	28 studies	54% ± 20%	Explore
CD4-positive, alpha-beta T cell	25 studies	35% ± 20%	Explore
non-classical monocyte	24 studies	77% ± 16%	Explore
T cell	22 studies	28% ± 12%	Explore
monocyte	22 studies	57% ± 25%	Explore
endothelial cell	22 studies	23% ± 9%	Explore
fibroblast	22 studies	28% ± 13%	Explore
basal cell	22 studies	44% ± 17%	Explore
natural killer cell	21 studies	26% ± 11%	Explore
memory B cell	20 studies	29% ± 10%	Explore
regulatory T cell	20 studies	34% ± 16%	Explore
CD8-positive, alpha-beta T cell	19 studies	35% ± 20%	Explore
epithelial cell	18 studies	48% ± 19%	Explore
dendritic cell	16 studies	53% ± 24%	Explore
smooth muscle cell	16 studies	24% ± 5%	Explore
naive B cell	14 studies	21% ± 6%	Explore
pericyte	14 studies	28% ± 8%	Explore
gamma-delta T cell	14 studies	27% ± 18%	Explore
myeloid cell	14 studies	52% ± 24%	Explore
plasmacytoid dendritic cell	13 studies	35% ± 10%	Explore
ciliated cell	13 studies	35% ± 13%	Explore
neutrophil	13 studies	53% ± 25%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	31% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	28% ± 10%	Explore
connective tissue cell	12 studies	31% ± 9%	Explore
type I pneumocyte	11 studies	48% ± 20%	Explore
type II pneumocyte	10 studies	54% ± 25%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	27% ± 6%	Explore
mature NK T cell	10 studies	25% ± 10%	Explore
mast cell	9 studies	29% ± 19%	Explore
plasma cell	9 studies	36% ± 16%	Explore
plasmablast	9 studies	50% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	35% ± 18%	Explore
secretory cell	9 studies	33% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	24% ± 5%	Explore
myofibroblast cell	9 studies	29% ± 7%	Explore
mucosal invariant T cell	9 studies	24% ± 4%	Explore
astrocyte	9 studies	31% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	31% ± 19%	Explore
progenitor cell	8 studies	57% ± 19%	Explore
abnormal cell	8 studies	29% ± 9%	Explore
adipocyte	8 studies	26% ± 7%	Explore
endothelial cell of vascular tree	8 studies	23% ± 8%	Explore
alveolar macrophage	7 studies	57% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	24% ± 8%	Explore
goblet cell	7 studies	26% ± 10%	Explore
hematopoietic stem cell	7 studies	80% ± 8%	Explore
hematopoietic precursor cell	6 studies	74% ± 16%	Explore
club cell	6 studies	36% ± 17%	Explore
epithelial cell of proximal tubule	6 studies	23% ± 7%	Explore
neuron	6 studies	43% ± 20%	Explore
leukocyte	6 studies	40% ± 17%	Explore
transit amplifying cell	6 studies	42% ± 23%	Explore
precursor B cell	6 studies	54% ± 18%	Explore
T follicular helper cell	6 studies	21% ± 4%	Explore
mononuclear phagocyte	5 studies	52% ± 25%	Explore
intestinal crypt stem cell	5 studies	40% ± 12%	Explore
pro-B cell	5 studies	69% ± 20%	Explore
innate lymphoid cell	5 studies	22% ± 2%	Explore
brush cell	5 studies	30% ± 19%	Explore
intermediate monocyte	5 studies	68% ± 21%	Explore
granulocyte	5 studies	44% ± 21%	Explore
erythrocyte	5 studies	42% ± 24%	Explore
endothelial cell of lymphatic vessel	4 studies	23% ± 7%	Explore
respiratory goblet cell	4 studies	31% ± 13%	Explore
pancreatic A cell	4 studies	28% ± 8%	Explore
enteroendocrine cell	4 studies	36% ± 11%	Explore
mesothelial cell	4 studies	32% ± 10%	Explore
retinal ganglion cell	4 studies	68% ± 23%	Explore
erythroblast	4 studies	53% ± 21%	Explore
immature B cell	4 studies	51% ± 20%	Explore
adventitial cell	4 studies	23% ± 1%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	57% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	48% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	38% ± 22%	Explore
hillock cell	3 studies	39% ± 17%	Explore
ionocyte	3 studies	33% ± 7%	Explore
precursor cell	3 studies	69% ± 8%	Explore
type B pancreatic cell	3 studies	46% ± 17%	Explore
exhausted T cell	3 studies	47% ± 17%	Explore
kidney loop of Henle epithelial cell	3 studies	19% ± 4%	Explore
endothelial cell of artery	3 studies	17% ± 2%	Explore
enterocyte	3 studies	28% ± 10%	Explore
vein endothelial cell	3 studies	26% ± 7%	Explore
GABAergic amacrine cell	3 studies	30% ± 10%	Explore
extravillous trophoblast	3 studies	51% ± 14%	Explore
placental villous trophoblast	3 studies	89% ± 9%	Explore
lymphocyte	3 studies	36% ± 13%	Explore
neuroendocrine cell	3 studies	37% ± 5%	Explore
T-helper 17 cell	3 studies	57% ± 26%	Explore
capillary endothelial cell	3 studies	32% ± 4%	Explore
amacrine cell	3 studies	32% ± 18%	Explore
microglial cell	3 studies	28% ± 15%	Explore
Mueller cell	3 studies	20% ± 2%	Explore
germinal center B cell	3 studies	53% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	23% ± 2%	Explore
inflammatory macrophage	3 studies	46% ± 12%	Explore
GABAergic neuron	3 studies	29% ± 9%	Explore
glutamatergic neuron	3 studies	28% ± 12%	Explore
acinar cell	3 studies	56% ± 16%	Explore
pancreatic ductal cell	3 studies	51% ± 12%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	79% ± 15%	Explore
hepatocyte	3 studies	43% ± 19%	Explore
group 3 innate lymphoid cell	3 studies	43% ± 18%	Explore
interneuron	3 studies	30% ± 16%	Explore
oligodendrocyte	3 studies	24% ± 11%	Explore
T-helper 1 cell	3 studies	39% ± 21%	Explore
double negative thymocyte	3 studies	50% ± 27%	Explore
progenitor cell of mammary luminal epithelium	3 studies	30% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	39% ± 12%	Explore
lung	17 studies	37% ± 12%	Explore
intestine	9 studies	27% ± 10%	Explore
brain	7 studies	24% ± 7%	Explore
kidney	6 studies	28% ± 7%	Explore
liver	6 studies	30% ± 19%	Explore
eye	5 studies	25% ± 6%	Explore
bone marrow	5 studies	35% ± 11%	Explore
lymph node	5 studies	30% ± 12%	Explore
pancreas	4 studies	39% ± 10%	Explore
placenta	4 studies	49% ± 19%	Explore
uterus	4 studies	35% ± 22%	Explore
breast	4 studies	22% ± 3%	Explore
prostate	3 studies	35% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	20791.82	653 / 653	100%	143.20	603 / 605
intestine	100%	11449.39	965 / 966	99%	147.42	524 / 527
lung	100%	16937.86	576 / 578	100%	172.24	1151 / 1155
uterus	100%	7393.27	170 / 170	99%	126.72	455 / 459
skin	99%	11129.07	1795 / 1809	100%	162.96	471 / 472
pancreas	100%	15354.52	328 / 328	99%	83.78	176 / 178
bladder	100%	21169.95	21 / 21	99%	155.69	497 / 504
ovary	100%	11556.27	180 / 180	99%	78.40	424 / 430
breast	100%	12334.89	459 / 459	99%	82.14	1102 / 1118
esophagus	100%	18053.46	1444 / 1445	98%	116.82	180 / 183
prostate	99%	8610.11	243 / 245	99%	73.58	495 / 502
brain	98%	8388.57	2580 / 2642	100%	82.41	705 / 705
stomach	98%	9855.06	352 / 359	99%	123.85	284 / 286
kidney	100%	10426.17	89 / 89	93%	66.70	842 / 901
adrenal gland	100%	16246.79	258 / 258	92%	60.29	212 / 230
liver	75%	5210.62	170 / 226	89%	90.61	361 / 406
adipose	100%	14513.57	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	184.68	80 / 80
lymph node	0%	0	0 / 0	100%	135.01	29 / 29
peripheral blood	100%	56266.97	929 / 929	0%	0	0 / 0
spleen	100%	17547.40	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	122.87	45 / 45
ureter	0%	0	0 / 0	100%	41.36	1 / 1
blood vessel	99%	8477.16	1328 / 1335	0%	0	0 / 0
heart	54%	2315.14	468 / 861	0%	0	0 / 0
muscle	10%	377.97	84 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006098	Biological process	pentose-phosphate shunt
GO_0046166	Biological process	glyceraldehyde-3-phosphate biosynthetic process
GO_0009052	Biological process	pentose-phosphate shunt, non-oxidative branch
GO_0040008	Biological process	regulation of growth
GO_1901159	Biological process	xylulose 5-phosphate biosynthetic process
GO_0070062	Cellular component	extracellular exosome
GO_0016604	Cellular component	nuclear body
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005777	Cellular component	peroxisome
GO_0031982	Cellular component	vesicle
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0042803	Molecular function	protein homodimerization activity
GO_0030976	Molecular function	thiamine pyrophosphate binding
GO_0004802	Molecular function	transketolase activity
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding
GO_0000287	Molecular function	magnesium ion binding

IV. Literature review

[source]

Gene name	TKT
Protein name	Transketolase Transketolase isoform 3 Transketolase (EC 2.2.1.1) Transketolase (TK) (EC 2.2.1.1) transketolase (EC 2.2.1.1)
Synonyms	HEL107
Description	FUNCTION: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. . FUNCTION: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. . FUNCTION: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. . FUNCTION: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. . FUNCTION: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. .
Accessions	F8WAX4 P29401 A0A0S2Z4T2 E9PFF2 ENST00000423525.6 [P29401-1] V9HWD9 ENST00000469678.1 ENST00000462138.6 [P29401-1] ENST00000450814.6 ENST00000423516.5 [P29401-2] F8W888 ENST00000472528.5 A0A0S2Z5C0

TKT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review