SUMO3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016925Biological processprotein sumoylation
GO_1900180Biological processregulation of protein localization to nucleus
GO_0043392Biological processnegative regulation of DNA binding
GO_0000776Cellular componentkinetochore
GO_0005654Cellular componentnucleoplasm
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0044389Molecular functionubiquitin-like protein ligase binding
GO_0031386Molecular functionprotein tag activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSUMO3
Protein nameSMT3 suppressor of mif two 3 homolog 3 (Yeast), isoform CRA_d (Small ubiquitin like modifier 3)
Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A)
Small ubiquitin like modifier 3
SynonymsSMT3A
SMT3H1
hCG_401304
DescriptionFUNCTION: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 . Plays a role in the regulation of sumoylation status of SETX . .

AccessionsA8MU27
A8MUA9
ENST00000397893.3
P55854
ENST00000397898.7
ENST00000411651.6 [P55854-2]
ENST00000332859.11 [P55854-1]