SRP72 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	24 studies	27% ± 10%	Explore
B cell	23 studies	23% ± 8%	Explore
natural killer cell	23 studies	24% ± 7%	Explore
fibroblast	23 studies	26% ± 10%	Explore
conventional dendritic cell	21 studies	28% ± 16%	Explore
macrophage	19 studies	21% ± 7%	Explore
classical monocyte	18 studies	23% ± 11%	Explore
CD4-positive, alpha-beta T cell	18 studies	25% ± 9%	Explore
CD8-positive, alpha-beta T cell	18 studies	24% ± 8%	Explore
smooth muscle cell	15 studies	21% ± 4%	Explore
naive B cell	15 studies	21% ± 4%	Explore
memory B cell	15 studies	21% ± 4%	Explore
plasmacytoid dendritic cell	15 studies	33% ± 9%	Explore
regulatory T cell	15 studies	21% ± 5%	Explore
pericyte	14 studies	23% ± 6%	Explore
plasma cell	13 studies	37% ± 12%	Explore
gamma-delta T cell	13 studies	25% ± 14%	Explore
T cell	12 studies	20% ± 5%	Explore
monocyte	12 studies	20% ± 4%	Explore
non-classical monocyte	12 studies	27% ± 14%	Explore
connective tissue cell	12 studies	24% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	25% ± 5%	Explore
plasmablast	10 studies	49% ± 21%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	25% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	25% ± 6%	Explore
dendritic cell	9 studies	43% ± 24%	Explore
endothelial cell of lymphatic vessel	9 studies	23% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	22% ± 6%	Explore
mature NK T cell	9 studies	21% ± 5%	Explore
myofibroblast cell	9 studies	24% ± 5%	Explore
mucosal invariant T cell	9 studies	23% ± 4%	Explore
epithelial cell	9 studies	35% ± 21%	Explore
basal cell	9 studies	28% ± 13%	Explore
endothelial cell of vascular tree	9 studies	21% ± 3%	Explore
endothelial cell of artery	8 studies	23% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	23% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	26% ± 5%	Explore
capillary endothelial cell	7 studies	21% ± 4%	Explore
abnormal cell	7 studies	21% ± 4%	Explore
vein endothelial cell	7 studies	20% ± 3%	Explore
hematopoietic precursor cell	6 studies	43% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	27% ± 10%	Explore
neuron	6 studies	29% ± 12%	Explore
hematopoietic stem cell	6 studies	33% ± 10%	Explore
mast cell	5 studies	21% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	28% ± 6%	Explore
precursor B cell	5 studies	29% ± 8%	Explore
pro-B cell	5 studies	30% ± 11%	Explore
myeloid cell	5 studies	34% ± 13%	Explore
immature B cell	5 studies	31% ± 17%	Explore
astrocyte	5 studies	25% ± 6%	Explore
secretory cell	5 studies	24% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	25% ± 11%	Explore
innate lymphoid cell	5 studies	20% ± 3%	Explore
GABAergic neuron	5 studies	34% ± 14%	Explore
goblet cell	5 studies	30% ± 10%	Explore
pancreatic A cell	4 studies	35% ± 13%	Explore
leukocyte	4 studies	25% ± 5%	Explore
exhausted T cell	4 studies	25% ± 9%	Explore
mesothelial cell	4 studies	27% ± 16%	Explore
erythroblast	4 studies	46% ± 23%	Explore
alveolar macrophage	4 studies	16% ± 0%	Explore
ciliated cell	4 studies	33% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	28% ± 4%	Explore
glutamatergic neuron	4 studies	47% ± 13%	Explore
oligodendrocyte precursor cell	4 studies	27% ± 6%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	48% ± 19%	Explore
oligodendrocyte	4 studies	24% ± 0%	Explore
IgA plasma cell	4 studies	22% ± 6%	Explore
IgG plasma cell	4 studies	21% ± 8%	Explore
type B pancreatic cell	3 studies	47% ± 15%	Explore
mononuclear phagocyte	3 studies	31% ± 10%	Explore
neural crest cell	3 studies	26% ± 2%	Explore
microglial cell	3 studies	19% ± 1%	Explore
extravillous trophoblast	3 studies	36% ± 10%	Explore
placental villous trophoblast	3 studies	32% ± 9%	Explore
common myeloid progenitor	3 studies	35% ± 15%	Explore
lymphocyte	3 studies	29% ± 9%	Explore
club cell	3 studies	24% ± 8%	Explore
germinal center B cell	3 studies	21% ± 0%	Explore
pancreatic ductal cell	3 studies	41% ± 16%	Explore
granulocyte monocyte progenitor cell	3 studies	41% ± 7%	Explore
enteroendocrine cell	3 studies	27% ± 8%	Explore
intestinal crypt stem cell	3 studies	24% ± 7%	Explore
T follicular helper cell	3 studies	19% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	32% ± 10%	Explore
interneuron	3 studies	41% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	19% ± 5%	Explore
double negative thymocyte	3 studies	38% ± 18%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	15 studies	26% ± 11%	Explore
lung	9 studies	27% ± 10%	Explore
brain	7 studies	30% ± 12%	Explore
intestine	6 studies	22% ± 10%	Explore
pancreas	4 studies	36% ± 17%	Explore
kidney	4 studies	19% ± 3%	Explore
placenta	4 studies	25% ± 6%	Explore
bone marrow	4 studies	25% ± 8%	Explore
uterus	4 studies	24% ± 12%	Explore
liver	4 studies	30% ± 18%	Explore
eye	3 studies	22% ± 6%	Explore
lymph node	3 studies	20% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	4708.64	459 / 459	100%	91.34	1118 / 1118
esophagus	100%	3907.41	1445 / 1445	100%	72.54	183 / 183
lung	100%	4219.49	578 / 578	100%	67.91	1155 / 1155
ovary	100%	4547.60	180 / 180	100%	55.29	430 / 430
pancreas	100%	4193.13	328 / 328	100%	47.59	178 / 178
intestine	100%	3833.98	966 / 966	100%	60.49	526 / 527
bladder	100%	4016.29	21 / 21	100%	55.39	503 / 504
prostate	100%	3468.63	245 / 245	100%	62.02	501 / 502
uterus	100%	4492.95	170 / 170	100%	54.40	458 / 459
thymus	100%	3882.32	653 / 653	100%	51.26	602 / 605
stomach	100%	3254.79	359 / 359	99%	61.52	284 / 286
brain	99%	2751.71	2619 / 2642	100%	61.59	705 / 705
liver	100%	2703.50	226 / 226	98%	33.30	399 / 406
kidney	100%	2822.11	89 / 89	98%	44.84	882 / 901
skin	100%	6927.41	1809 / 1809	98%	70.95	462 / 472
adrenal gland	100%	4058.39	258 / 258	96%	43.97	221 / 230
adipose	100%	4735.61	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4498.64	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	54.26	29 / 29
spleen	100%	3971.61	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	57.07	45 / 45
ureter	0%	0	0 / 0	100%	25.93	1 / 1
muscle	100%	2904.66	802 / 803	0%	0	0 / 0
heart	95%	2106.92	818 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	36.09	75 / 80
peripheral blood	92%	3630.19	852 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006614	Biological process	SRP-dependent cotranslational protein targeting to membrane
GO_0005786	Cellular component	signal recognition particle, endoplasmic reticulum targeting
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0048500	Cellular component	signal recognition particle
GO_0043022	Molecular function	ribosome binding
GO_0030911	Molecular function	TPR domain binding
GO_0005047	Molecular function	signal recognition particle binding
GO_0008312	Molecular function	7S RNA binding
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	SRP72
Protein name	Signal recognition particle 72 Signal recognition particle subunit SRP72 SRP72 protein Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein) SRP72 protein (Similar to signal recognition particle 72kDa)
Synonyms	HEL103 hCG_2027162
Description	FUNCTION: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) . The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER . The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER . Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 . Can bind 7SL RNA with low affinity . The SRP complex possibly participates in the elongation arrest function (By similarity). . FUNCTION: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). .
Accessions	Q0D2M6 V9HWK0 ENST00000642900.1 [O76094-1] D6RDY6 ENST00000510663.6 [O76094-2] R4GNC1 O76094 A0PJJ5 Q86X80 ENST00000504757.2 ENST00000505314.2

SRP72 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review