SNX6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	37 studies	45% ± 17%	Explore
endothelial cell	36 studies	29% ± 11%	Explore
natural killer cell	32 studies	29% ± 9%	Explore
CD4-positive, alpha-beta T cell	30 studies	26% ± 9%	Explore
fibroblast	28 studies	26% ± 10%	Explore
CD8-positive, alpha-beta T cell	26 studies	27% ± 7%	Explore
B cell	25 studies	24% ± 7%	Explore
pericyte	22 studies	26% ± 12%	Explore
regulatory T cell	22 studies	34% ± 9%	Explore
T cell	21 studies	26% ± 5%	Explore
non-classical monocyte	21 studies	36% ± 11%	Explore
classical monocyte	21 studies	33% ± 12%	Explore
conventional dendritic cell	20 studies	26% ± 14%	Explore
monocyte	19 studies	29% ± 9%	Explore
smooth muscle cell	19 studies	23% ± 5%	Explore
endothelial cell of lymphatic vessel	17 studies	27% ± 8%	Explore
memory B cell	16 studies	24% ± 7%	Explore
naive B cell	16 studies	24% ± 6%	Explore
mature NK T cell	16 studies	28% ± 9%	Explore
dendritic cell	16 studies	32% ± 20%	Explore
epithelial cell	15 studies	32% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	28% ± 8%	Explore
gamma-delta T cell	15 studies	33% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	32% ± 9%	Explore
myeloid cell	14 studies	40% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	31% ± 9%	Explore
mast cell	12 studies	23% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	29% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	32% ± 8%	Explore
mucosal invariant T cell	12 studies	30% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	32% ± 11%	Explore
basal cell	11 studies	34% ± 16%	Explore
capillary endothelial cell	11 studies	21% ± 5%	Explore
connective tissue cell	11 studies	30% ± 9%	Explore
plasmacytoid dendritic cell	11 studies	28% ± 8%	Explore
myofibroblast cell	10 studies	28% ± 8%	Explore
vein endothelial cell	10 studies	23% ± 7%	Explore
microglial cell	10 studies	24% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	32% ± 9%	Explore
adipocyte	9 studies	26% ± 8%	Explore
oligodendrocyte	9 studies	30% ± 12%	Explore
alveolar macrophage	8 studies	24% ± 6%	Explore
ciliated cell	8 studies	33% ± 17%	Explore
club cell	8 studies	25% ± 11%	Explore
abnormal cell	8 studies	24% ± 6%	Explore
endothelial cell of artery	8 studies	22% ± 3%	Explore
endothelial cell of vascular tree	8 studies	23% ± 6%	Explore
type I pneumocyte	7 studies	22% ± 3%	Explore
secretory cell	7 studies	29% ± 16%	Explore
T follicular helper cell	7 studies	31% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	35% ± 9%	Explore
leukocyte	6 studies	36% ± 6%	Explore
mononuclear phagocyte	6 studies	34% ± 15%	Explore
lymphocyte	6 studies	29% ± 9%	Explore
precursor B cell	6 studies	28% ± 8%	Explore
mesothelial cell	6 studies	29% ± 10%	Explore
neuron	6 studies	41% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	38% ± 11%	Explore
hematopoietic precursor cell	5 studies	27% ± 13%	Explore
exhausted T cell	5 studies	34% ± 7%	Explore
neutrophil	5 studies	18% ± 2%	Explore
respiratory goblet cell	5 studies	24% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	43% ± 9%	Explore
glutamatergic neuron	5 studies	44% ± 18%	Explore
cardiac muscle cell	5 studies	24% ± 2%	Explore
innate lymphoid cell	5 studies	28% ± 7%	Explore
GABAergic neuron	5 studies	39% ± 16%	Explore
astrocyte	5 studies	28% ± 5%	Explore
oligodendrocyte precursor cell	5 studies	29% ± 9%	Explore
CD4-positive helper T cell	4 studies	26% ± 8%	Explore
plasmablast	4 studies	43% ± 15%	Explore
kidney loop of Henle epithelial cell	4 studies	21% ± 2%	Explore
immature B cell	4 studies	29% ± 5%	Explore
type II pneumocyte	4 studies	24% ± 4%	Explore
hematopoietic stem cell	4 studies	27% ± 7%	Explore
enteroendocrine cell	4 studies	25% ± 10%	Explore
goblet cell	4 studies	30% ± 9%	Explore
T-helper 17 cell	4 studies	26% ± 7%	Explore
interneuron	4 studies	37% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	30% ± 9%	Explore
plasma cell	3 studies	28% ± 11%	Explore
platelet	3 studies	18% ± 1%	Explore
glomerular endothelial cell	3 studies	20% ± 0%	Explore
progenitor cell	3 studies	25% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	22% ± 3%	Explore
renal alpha-intercalated cell	3 studies	26% ± 2%	Explore
neural crest cell	3 studies	27% ± 3%	Explore
placental villous trophoblast	3 studies	60% ± 17%	Explore
megakaryocyte	3 studies	22% ± 3%	Explore
pro-B cell	3 studies	27% ± 4%	Explore
tissue-resident macrophage	3 studies	42% ± 4%	Explore
intermediate monocyte	3 studies	52% ± 13%	Explore
endothelial cell of sinusoid	3 studies	29% ± 9%	Explore
muscle cell	3 studies	25% ± 7%	Explore
granulocyte	3 studies	23% ± 7%	Explore
enterocyte	3 studies	20% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	37% ± 15%	Explore
transit amplifying cell	3 studies	28% ± 14%	Explore
T-helper 1 cell	3 studies	35% ± 8%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	38% ± 9%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	32% ± 11%	Explore
double negative thymocyte	3 studies	43% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	32% ± 9%	Explore
lung	14 studies	30% ± 13%	Explore
brain	9 studies	32% ± 14%	Explore
intestine	7 studies	25% ± 11%	Explore
kidney	6 studies	24% ± 5%	Explore
heart	5 studies	22% ± 5%	Explore
bone marrow	4 studies	24% ± 9%	Explore
uterus	4 studies	32% ± 15%	Explore
lymph node	4 studies	24% ± 4%	Explore
liver	4 studies	32% ± 9%	Explore
adipose	4 studies	31% ± 7%	Explore
placenta	3 studies	47% ± 13%	Explore
eye	3 studies	22% ± 7%	Explore
breast	3 studies	22% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2755.50	1445 / 1445	100%	63.94	183 / 183
ovary	100%	2373.85	180 / 180	100%	61.30	430 / 430
brain	100%	2437.36	2639 / 2642	100%	53.80	705 / 705
breast	100%	3550.93	459 / 459	100%	62.14	1116 / 1118
stomach	100%	2438.26	359 / 359	100%	49.22	285 / 286
lung	100%	2621.85	576 / 578	100%	67.57	1154 / 1155
uterus	100%	2736.59	170 / 170	99%	59.14	455 / 459
thymus	100%	2488.53	653 / 653	99%	46.04	599 / 605
intestine	100%	3125.88	966 / 966	99%	49.25	521 / 527
bladder	100%	2976.00	21 / 21	99%	53.11	497 / 504
kidney	100%	2650.01	89 / 89	98%	49.29	885 / 901
prostate	100%	2128.52	244 / 245	98%	38.95	493 / 502
skin	100%	4297.50	1808 / 1809	95%	52.84	447 / 472
adrenal gland	100%	3429.83	258 / 258	92%	32.60	211 / 230
pancreas	93%	1053.63	305 / 328	98%	50.01	175 / 178
liver	93%	990.01	210 / 226	88%	21.34	357 / 406
adipose	100%	4173.96	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3440.79	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	49.42	29 / 29
spleen	100%	3442.88	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	50.85	45 / 45
ureter	0%	0	0 / 0	100%	16.81	1 / 1
muscle	100%	2164.03	802 / 803	0%	0	0 / 0
heart	97%	1917.50	834 / 861	0%	0	0 / 0
peripheral blood	95%	3061.66	882 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	76%	21.46	61 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030512	Biological process	negative regulation of transforming growth factor beta receptor signaling pathway
GO_0071364	Biological process	cellular response to epidermal growth factor stimulus
GO_0006886	Biological process	intracellular protein transport
GO_0099072	Biological process	regulation of postsynaptic membrane neurotransmitter receptor levels
GO_0042147	Biological process	retrograde transport, endosome to Golgi
GO_1903593	Biological process	regulation of histamine secretion by mast cell
GO_0007175	Biological process	negative regulation of epidermal growth factor-activated receptor activity
GO_0016241	Biological process	regulation of macroautophagy
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_1904646	Biological process	cellular response to amyloid-beta
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0098978	Cellular component	glutamatergic synapse
GO_0097422	Cellular component	tubular endosome
GO_0031901	Cellular component	early endosome membrane
GO_0005764	Cellular component	lysosome
GO_0030904	Cellular component	retromer complex
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0030905	Cellular component	retromer, tubulation complex
GO_0005768	Cellular component	endosome
GO_0005634	Cellular component	nucleus
GO_0042803	Molecular function	protein homodimerization activity
GO_0034452	Molecular function	dynactin binding
GO_0035091	Molecular function	phosphatidylinositol binding
GO_0034713	Molecular function	type I transforming growth factor beta receptor binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SNX6
Protein name	Sorting nexin Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed] Sorting nexin 6, isoform CRA_e (cDNA FLJ58001, highly similar to Sorting nexin-6) Sorting nexin 6
Synonyms	hCG_2013610
Description	FUNCTION: Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex . The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity . Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R . May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network . Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation . In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable). . FUNCTION: Involved in several stages of intracellular trafficking. .
Accessions	G3V589 A0A0A0MRI2 G3V5X9 ENST00000652385.1 ENST00000557265.6 ENST00000555648.1 ENST00000556712.6 ENST00000555416.6 H0YJF8 ENST00000396526.7 [Q9UNH7-2] Q9UNH7 ENST00000557341.6 ENST00000362031.10 [Q9UNH7-1] G3V5U2 ENST00000556162.6 B4DJS7 G3V4Z5 G3V2U1

SNX6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review