SMARCE1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030071Biological processregulation of mitotic metaphase/anaphase transition
GO_0045582Biological processpositive regulation of T cell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0045663Biological processpositive regulation of myoblast differentiation
GO_0006338Biological processchromatin remodeling
GO_0070316Biological processregulation of G0 to G1 transition
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0045597Biological processpositive regulation of cell differentiation
GO_0022008Biological processneurogenesis
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_2000819Biological processregulation of nucleotide-excision repair
GO_0006337Biological processnucleosome disassembly
GO_2000781Biological processpositive regulation of double-strand break repair
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0071565Cellular componentnBAF complex
GO_0000228Cellular componentnuclear chromosome
GO_0071564Cellular componentnpBAF complex
GO_0000776Cellular componentkinetochore
GO_0032991Cellular componentprotein-containing complex
GO_0016514Cellular componentSWI/SNF complex
GO_0005654Cellular componentnucleoplasm
GO_0016363Cellular componentnuclear matrix
GO_0016586Cellular componentRSC-type complex
GO_0035060Cellular componentbrahma complex
GO_0000785Cellular componentchromatin
GO_0140092Cellular componentbBAF complex
GO_0005634Cellular componentnucleus
GO_0016922Molecular functionnuclear receptor binding
GO_0003682Molecular functionchromatin binding
GO_0031492Molecular functionnucleosomal DNA binding
GO_0003723Molecular functionRNA binding
GO_0008080Molecular functionN-acetyltransferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSMARCE1
Protein nameSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 (cDNA FLJ55202, highly similar to SWI/SNF-related matrix-associatedactin-dependent regulator of chromatin subfamily E member 1)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57)
SynonymsBAF57
DescriptionFUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. .

AccessionsENST00000481231.6
J3QKX6
A0A2R8YES3
A0A2R8YFC8
ENST00000478349.7
ENST00000644909.1
ENST00000400122.8 [Q969G3-6]
ENST00000348513.12 [Q969G3-1]
A0A2R8Y4T4
ENST00000646482.1
B4DGM3
ENST00000580654.6
A0A2R8YEB8
J3QKS7
J3QS32
ENST00000642459.1
ENST00000580419.6
J3QL66
ENST00000647294.1
ENST00000645227.1
ENST00000578044.6 [Q969G3-3]
ENST00000643318.1 [Q969G3-3]
ENST00000474246.2
Q969G3
ENST00000645478.1
J3KT85
ENST00000447024.6 [Q969G3-2]
ENST00000643806.1
ENST00000647508.1 [Q969G3-4]
ENST00000578112.6
ENST00000643683.1 [Q969G3-1]
ENST00000647515.1
A0A2R8YDD9
ENST00000646283.1
ENST00000431889.6
J3QR61
A0A2R8Y7I9
ENST00000646856.1
ENST00000377808.9 [Q969G3-5]
A0A2R8Y7U4
A0A2U3TZQ7
ENST00000264640.9 [Q969G3-2]
ENST00000645104.1
ENST00000577721.6
A0A2R8Y855
A0A2R8Y765
ENST00000644527.1
ENST00000644701.1 [Q969G3-2]
A0A2R8YD78
A0A2R8YDQ4
ENST00000582955.6