SMAD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0017015Biological processregulation of transforming growth factor beta receptor signaling pathway
GO_0030324Biological processlung development
GO_0008283Biological processcell population proliferation
GO_0003203Biological processendocardial cushion morphogenesis
GO_0023019Biological processsignal transduction involved in regulation of gene expression
GO_0060395Biological processSMAD protein signal transduction
GO_0001707Biological processmesoderm formation
GO_0030513Biological processpositive regulation of BMP signaling pathway
GO_0030073Biological processinsulin secretion
GO_0048701Biological processembryonic cranial skeleton morphogenesis
GO_0001706Biological processendoderm formation
GO_0070723Biological processresponse to cholesterol
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0001657Biological processureteric bud development
GO_0071333Biological processcellular response to glucose stimulus
GO_0001701Biological processin utero embryonic development
GO_0010628Biological processpositive regulation of gene expression
GO_0007369Biological processgastrulation
GO_0006351Biological processDNA-templated transcription
GO_0045165Biological processcell fate commitment
GO_0030325Biological processadrenal gland development
GO_0006355Biological processregulation of DNA-templated transcription
GO_0048340Biological processparaxial mesoderm morphogenesis
GO_0009653Biological processanatomical structure morphogenesis
GO_0003184Biological processpulmonary valve morphogenesis
GO_0003140Biological processdetermination of left/right asymmetry in lateral mesoderm
GO_0048617Biological processembryonic foregut morphogenesis
GO_0035265Biological processorgan growth
GO_0031016Biological processpancreas development
GO_0051098Biological processregulation of binding
GO_0003180Biological processaortic valve morphogenesis
GO_0071895Biological processodontoblast differentiation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0038092Biological processnodal signaling pathway
GO_0009952Biological processanterior/posterior pattern specification
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0032924Biological processactivin receptor signaling pathway
GO_0009791Biological processpost-embryonic development
GO_0060039Biological processpericardium development
GO_0062009Biological processsecondary palate development
GO_0035556Biological processintracellular signal transduction
GO_0030154Biological processcell differentiation
GO_0010718Biological processpositive regulation of epithelial to mesenchymal transition
GO_0007352Biological processzygotic specification of dorsal/ventral axis
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0031053Biological processprimary miRNA processing
GO_0005634Cellular componentnucleus
GO_0071141Cellular componentSMAD protein complex
GO_0005654Cellular componentnucleoplasm
GO_0071142Cellular componenthomomeric SMAD protein complex
GO_0032991Cellular componentprotein-containing complex
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005829Cellular componentcytosol
GO_0032444Cellular componentactivin responsive factor complex
GO_0071144Cellular componentheteromeric SMAD protein complex
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0048156Molecular functiontau protein binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0070410Molecular functionco-SMAD binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0019902Molecular functionphosphatase binding
GO_0046872Molecular functionmetal ion binding
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0046332Molecular functionSMAD binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding
GO_0003677Molecular functionDNA binding
GO_0070412Molecular functionR-SMAD binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0034713Molecular functiontype I transforming growth factor beta receptor binding
GO_0070411Molecular functionI-SMAD binding
GO_0005160Molecular functiontransforming growth factor beta receptor binding
GO_0097718Molecular functiondisordered domain specific binding

IV. Literature review

[source]
Gene nameSMAD2
Protein nameMothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
SMAD family member 2
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
SynonymshCG_22544
MADR2
MADH2
DescriptionFUNCTION: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma . .

AccessionsENST00000262160.11 [Q15796-1]
ENST00000591214.5
ENST00000586514.5
Q53XR6
ENST00000587269.5
ENST00000587421.5
K7EL92
ENST00000585978.1
K7ESI8
ENST00000586040.5 [Q15796-2]
K7EJX0
ENST00000356825.8 [Q15796-2]
K7ERC7
ENST00000589877.5
ENST00000402690.6 [Q15796-1]
Q15796
B7Z5N5