SLC38A1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	39 studies	33% ± 10%	Explore
B cell	38 studies	31% ± 11%	Explore
CD8-positive, alpha-beta T cell	33 studies	32% ± 8%	Explore
CD4-positive, alpha-beta T cell	32 studies	30% ± 8%	Explore
T cell	31 studies	30% ± 10%	Explore
regulatory T cell	25 studies	33% ± 8%	Explore
naive B cell	19 studies	37% ± 10%	Explore
endothelial cell of lymphatic vessel	18 studies	35% ± 13%	Explore
memory B cell	18 studies	28% ± 8%	Explore
mature NK T cell	18 studies	32% ± 7%	Explore
plasmacytoid dendritic cell	17 studies	37% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	34% ± 10%	Explore
gamma-delta T cell	17 studies	35% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	41% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	36% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	38% ± 10%	Explore
mucosal invariant T cell	14 studies	39% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	35% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	40% ± 11%	Explore
glutamatergic neuron	12 studies	42% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	40% ± 12%	Explore
oligodendrocyte precursor cell	11 studies	36% ± 14%	Explore
GABAergic neuron	10 studies	48% ± 22%	Explore
epithelial cell	10 studies	40% ± 15%	Explore
dendritic cell	9 studies	26% ± 13%	Explore
smooth muscle cell	9 studies	22% ± 6%	Explore
abnormal cell	9 studies	22% ± 7%	Explore
basal cell	9 studies	31% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	30% ± 5%	Explore
astrocyte	8 studies	29% ± 10%	Explore
leukocyte	7 studies	38% ± 20%	Explore
conventional dendritic cell	7 studies	29% ± 18%	Explore
neuron	7 studies	37% ± 13%	Explore
T follicular helper cell	7 studies	30% ± 9%	Explore
type I pneumocyte	6 studies	20% ± 4%	Explore
plasma cell	6 studies	27% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	30% ± 7%	Explore
interneuron	6 studies	58% ± 17%	Explore
retinal ganglion cell	6 studies	67% ± 22%	Explore
lymphocyte	6 studies	44% ± 20%	Explore
retinal cone cell	6 studies	45% ± 19%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	34% ± 13%	Explore
innate lymphoid cell	6 studies	32% ± 12%	Explore
exhausted T cell	5 studies	36% ± 6%	Explore
endothelial cell	5 studies	32% ± 22%	Explore
retinal bipolar neuron	5 studies	65% ± 11%	Explore
OFF-bipolar cell	5 studies	60% ± 15%	Explore
ON-bipolar cell	5 studies	57% ± 15%	Explore
precursor B cell	5 studies	33% ± 9%	Explore
pro-B cell	5 studies	34% ± 9%	Explore
amacrine cell	5 studies	28% ± 10%	Explore
cardiac muscle cell	5 studies	31% ± 6%	Explore
oligodendrocyte	5 studies	23% ± 7%	Explore
goblet cell	5 studies	25% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	32% ± 9%	Explore
immature B cell	4 studies	31% ± 3%	Explore
retinal rod cell	4 studies	19% ± 4%	Explore
CD4-positive helper T cell	4 studies	33% ± 12%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	44% ± 11%	Explore
type II pneumocyte	4 studies	26% ± 9%	Explore
T-helper 17 cell	4 studies	24% ± 5%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	37% ± 12%	Explore
renal principal cell	4 studies	53% ± 8%	Explore
ionocyte	3 studies	36% ± 7%	Explore
plasmablast	3 studies	39% ± 14%	Explore
mesothelial cell	3 studies	21% ± 1%	Explore
GABAergic interneuron	3 studies	48% ± 10%	Explore
granule cell	3 studies	36% ± 9%	Explore
pericyte	3 studies	32% ± 16%	Explore
placental villous trophoblast	3 studies	43% ± 26%	Explore
club cell	3 studies	22% ± 5%	Explore
retina horizontal cell	3 studies	19% ± 2%	Explore
GABAergic amacrine cell	3 studies	33% ± 6%	Explore
glycinergic amacrine cell	3 studies	26% ± 3%	Explore
rod bipolar cell	3 studies	72% ± 4%	Explore
germinal center B cell	3 studies	26% ± 2%	Explore
muscle cell	3 studies	31% ± 4%	Explore
pancreatic ductal cell	3 studies	47% ± 22%	Explore
mast cell	3 studies	27% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	33% ± 9%	Explore
transit amplifying cell	3 studies	38% ± 30%	Explore
T-helper 1 cell	3 studies	31% ± 7%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	32% ± 7%	Explore
double negative thymocyte	3 studies	41% ± 10%	Explore
erythrocyte	3 studies	18% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	25% ± 6%	Explore
brain	12 studies	38% ± 18%	Explore
eye	10 studies	28% ± 9%	Explore
lung	7 studies	20% ± 4%	Explore
kidney	5 studies	21% ± 4%	Explore
lymph node	5 studies	26% ± 7%	Explore
intestine	4 studies	18% ± 1%	Explore
bone marrow	3 studies	28% ± 8%	Explore
breast	3 studies	18% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	12654.11	1444 / 1445	99%	83.33	181 / 183
intestine	100%	11807.86	966 / 966	97%	70.88	511 / 527
bladder	100%	4702.43	21 / 21	96%	67.27	485 / 504
uterus	99%	6016.98	169 / 170	94%	57.96	430 / 459
prostate	99%	5827.14	243 / 245	92%	38.21	461 / 502
thymus	100%	6385.44	651 / 653	91%	41.24	548 / 605
kidney	91%	3831.84	81 / 89	99%	96.54	888 / 901
ovary	90%	2825.69	162 / 180	99%	63.08	425 / 430
stomach	95%	7387.81	340 / 359	94%	66.44	269 / 286
pancreas	96%	3753.67	315 / 328	93%	40.53	165 / 178
lung	96%	3892.91	555 / 578	91%	52.83	1056 / 1155
breast	80%	5910.35	369 / 459	97%	150.29	1084 / 1118
brain	91%	6266.07	2392 / 2642	86%	57.88	606 / 705
skin	100%	8222.95	1808 / 1809	33%	13.92	157 / 472
lymph node	0%	0	0 / 0	100%	70.19	29 / 29
spleen	100%	7405.45	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	22.59	1 / 1
blood vessel	96%	7513.46	1287 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	57.80	43 / 45
muscle	94%	21175.40	754 / 803	0%	0	0 / 0
heart	90%	7207.61	771 / 861	0%	0	0 / 0
adrenal gland	17%	388.58	45 / 258	66%	33.50	151 / 230
peripheral blood	71%	6939.45	656 / 929	0%	0	0 / 0
adipose	70%	2085.35	844 / 1204	0%	0	0 / 0
liver	31%	977.46	71 / 226	32%	15.69	130 / 406
eye	0%	0	0 / 0	9%	2.44	7 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006868	Biological process	glutamine transport
GO_0150104	Biological process	transport across blood-brain barrier
GO_0006541	Biological process	glutamine metabolic process
GO_0007565	Biological process	female pregnancy
GO_0032328	Biological process	alanine transport
GO_0015804	Biological process	neutral amino acid transport
GO_0048167	Biological process	regulation of synaptic plasticity
GO_0001504	Biological process	neurotransmitter uptake
GO_0015816	Biological process	glycine transport
GO_0003333	Biological process	amino acid transmembrane transport
GO_1902475	Biological process	L-alpha-amino acid transmembrane transport
GO_1901036	Biological process	positive regulation of L-glutamine import across plasma membrane
GO_0006865	Biological process	amino acid transport
GO_0043090	Biological process	amino acid import
GO_0009449	Biological process	gamma-aminobutyric acid biosynthetic process
GO_0035725	Biological process	sodium ion transmembrane transport
GO_0032228	Biological process	regulation of synaptic transmission, GABAergic
GO_0016323	Cellular component	basolateral plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0043025	Cellular component	neuronal cell body
GO_0098591	Cellular component	external side of apical plasma membrane
GO_0030424	Cellular component	axon
GO_0005283	Molecular function	amino acid:sodium symporter activity
GO_0015171	Molecular function	amino acid transmembrane transporter activity
GO_0015655	Molecular function	alanine:sodium symporter activity
GO_0015179	Molecular function	L-amino acid transmembrane transporter activity
GO_0015186	Molecular function	L-glutamine transmembrane transporter activity
GO_0005298	Molecular function	proline:sodium symporter activity
GO_0015175	Molecular function	neutral L-amino acid transmembrane transporter activity
GO_0015375	Molecular function	glycine:sodium symporter activity
GO_0005515	Molecular function	protein binding
GO_0005295	Molecular function	neutral L-amino acid:sodium symporter activity

IV. Literature review

[source]

Gene name	SLC38A1
Protein name	Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1) Solute carrier family 38 member 1
Synonyms	ATA1 SNAT1 SAT1 NAT2
Description	FUNCTION: Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane . The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient . Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblasts . Also regulates synaptic plasticity . .
Accessions	Q9H2H9 ENST00000550173.1 F8VX04 ENST00000552197.5 F8VX12 ENST00000549049.5 ENST00000612161.4 ENST00000439706.5 ENST00000398637.10 ENST00000546893.5

SLC38A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review