SECISBP2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	23 studies	24% ± 7%	Explore
endothelial cell	23 studies	27% ± 9%	Explore
naive B cell	17 studies	22% ± 5%	Explore
CD8-positive, alpha-beta T cell	15 studies	19% ± 3%	Explore
CD4-positive, alpha-beta T cell	14 studies	22% ± 7%	Explore
memory B cell	14 studies	20% ± 4%	Explore
T cell	13 studies	21% ± 4%	Explore
regulatory T cell	13 studies	21% ± 4%	Explore
fibroblast	13 studies	24% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	23% ± 6%	Explore
natural killer cell	11 studies	20% ± 3%	Explore
plasmacytoid dendritic cell	11 studies	23% ± 5%	Explore
astrocyte	11 studies	26% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	20% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	22% ± 6%	Explore
oligodendrocyte	10 studies	29% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	20% ± 3%	Explore
microglial cell	9 studies	27% ± 10%	Explore
mucosal invariant T cell	9 studies	20% ± 3%	Explore
type I pneumocyte	8 studies	23% ± 7%	Explore
amacrine cell	8 studies	26% ± 7%	Explore
macrophage	8 studies	29% ± 9%	Explore
oligodendrocyte precursor cell	8 studies	28% ± 12%	Explore
epithelial cell	8 studies	33% ± 16%	Explore
ciliated cell	8 studies	28% ± 9%	Explore
endothelial cell of lymphatic vessel	7 studies	29% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	20% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	20% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	23% ± 4%	Explore
mature NK T cell	7 studies	18% ± 3%	Explore
abnormal cell	7 studies	21% ± 4%	Explore
retinal rod cell	7 studies	28% ± 8%	Explore
pericyte	7 studies	25% ± 11%	Explore
basal cell	7 studies	26% ± 13%	Explore
type II pneumocyte	7 studies	25% ± 10%	Explore
GABAergic neuron	7 studies	37% ± 17%	Explore
gamma-delta T cell	7 studies	23% ± 10%	Explore
glutamatergic neuron	6 studies	44% ± 24%	Explore
interneuron	6 studies	36% ± 18%	Explore
myeloid cell	6 studies	23% ± 3%	Explore
retina horizontal cell	6 studies	25% ± 4%	Explore
adipocyte	6 studies	22% ± 7%	Explore
mast cell	6 studies	23% ± 4%	Explore
smooth muscle cell	6 studies	23% ± 3%	Explore
Mueller cell	6 studies	22% ± 6%	Explore
capillary endothelial cell	5 studies	19% ± 4%	Explore
neuron	5 studies	34% ± 13%	Explore
retinal bipolar neuron	5 studies	33% ± 8%	Explore
retinal cone cell	5 studies	27% ± 9%	Explore
dendritic cell	5 studies	27% ± 13%	Explore
T follicular helper cell	5 studies	20% ± 3%	Explore
goblet cell	5 studies	31% ± 18%	Explore
club cell	5 studies	28% ± 13%	Explore
non-classical monocyte	4 studies	28% ± 9%	Explore
precursor B cell	4 studies	25% ± 4%	Explore
plasma cell	4 studies	30% ± 11%	Explore
retinal pigment epithelial cell	4 studies	31% ± 12%	Explore
lymphocyte	4 studies	31% ± 10%	Explore
respiratory goblet cell	4 studies	28% ± 13%	Explore
endothelial cell of vascular tree	4 studies	26% ± 12%	Explore
hepatocyte	4 studies	34% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	18% ± 3%	Explore
pancreatic A cell	3 studies	28% ± 9%	Explore
classical monocyte	3 studies	27% ± 6%	Explore
plasmablast	3 studies	39% ± 15%	Explore
glial cell	3 studies	23% ± 4%	Explore
granule cell	3 studies	23% ± 4%	Explore
pro-B cell	3 studies	24% ± 1%	Explore
immature B cell	3 studies	24% ± 2%	Explore
GABAergic amacrine cell	3 studies	24% ± 3%	Explore
OFF-bipolar cell	3 studies	29% ± 4%	Explore
ON-bipolar cell	3 studies	29% ± 5%	Explore
glycinergic amacrine cell	3 studies	27% ± 3%	Explore
rod bipolar cell	3 studies	38% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	17% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	27% ± 8%	Explore
enteroendocrine cell	3 studies	26% ± 7%	Explore
intestinal crypt stem cell	3 studies	19% ± 5%	Explore
monocyte	3 studies	26% ± 2%	Explore
transit amplifying cell	3 studies	28% ± 17%	Explore
brush cell	3 studies	23% ± 5%	Explore
double negative thymocyte	3 studies	27% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	11 studies	34% ± 18%	Explore
peripheral blood	10 studies	23% ± 8%	Explore
eye	8 studies	31% ± 9%	Explore
lung	6 studies	23% ± 6%	Explore
adipose	4 studies	21% ± 3%	Explore
pancreas	3 studies	29% ± 9%	Explore
heart	3 studies	19% ± 1%	Explore
liver	3 studies	28% ± 9%	Explore
intestine	3 studies	21% ± 5%	Explore
lymph node	3 studies	18% ± 0%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3580.66	1445 / 1445	100%	13.45	183 / 183
pancreas	100%	4287.52	328 / 328	100%	15.49	178 / 178
stomach	100%	3882.45	359 / 359	100%	14.69	286 / 286
breast	100%	5005.03	459 / 459	100%	22.93	1117 / 1118
lung	100%	5263.80	578 / 578	100%	14.71	1153 / 1155
intestine	100%	4790.48	966 / 966	100%	17.13	526 / 527
bladder	100%	4771.38	21 / 21	100%	15.23	503 / 504
prostate	100%	5122.54	245 / 245	100%	23.99	501 / 502
thymus	100%	6493.95	653 / 653	100%	23.38	603 / 605
brain	100%	3339.46	2629 / 2642	100%	19.68	705 / 705
liver	100%	2606.38	226 / 226	100%	11.33	404 / 406
uterus	100%	6557.07	170 / 170	99%	13.56	456 / 459
kidney	100%	4778.18	89 / 89	99%	15.90	892 / 901
ovary	100%	7781.98	180 / 180	99%	9.06	425 / 430
adrenal gland	100%	4625.43	258 / 258	97%	16.44	224 / 230
skin	100%	4259.46	1809 / 1809	97%	15.54	456 / 472
adipose	100%	4347.58	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	14.77	29 / 29
muscle	100%	4380.40	803 / 803	0%	0	0 / 0
spleen	100%	6790.24	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	12.18	45 / 45
ureter	0%	0	0 / 0	100%	7.98	1 / 1
blood vessel	100%	3470.71	1333 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	16.63	79 / 80
heart	99%	2080.29	850 / 861	0%	0	0 / 0
peripheral blood	98%	2621.69	909 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_2000623	Biological process	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0001514	Biological process	selenocysteine incorporation
GO_0021756	Biological process	striatum development
GO_0021884	Biological process	forebrain neuron development
GO_0005739	Cellular component	mitochondrion
GO_0005654	Cellular component	nucleoplasm
GO_1990904	Cellular component	ribonucleoprotein complex
GO_0003677	Molecular function	DNA binding
GO_0003730	Molecular function	mRNA 3'-UTR binding
GO_0043021	Molecular function	ribonucleoprotein complex binding
GO_0005515	Molecular function	protein binding
GO_0035368	Molecular function	selenocysteine insertion sequence binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	SECISBP2
Protein name	SECIS binding protein 2 Selenocysteine insertion sequence-binding protein 2 Selenocysteine insertion sequence-binding protein 2 (SECIS-binding protein 2) SECISBP2 protein
Synonyms	SBP2
Description	FUNCTION: mRNA-binding protein that binds to the SECIS (selenocysteine insertion sequence) element present in the 3'-UTR of mRNAs encoding selenoproteins and facilitates the incorporation of the rare amino acid selenocysteine . Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling . (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation . (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur . .
Accessions	A0A1S5UZH3 ENST00000440898.1 Q5HYY5 Q96T21 ENST00000339901.8 [Q96T21-2] Q4V370 ENST00000534113.6 [Q96T21-3] ENST00000375807.8 [Q96T21-1] ENST00000425851.1 A4FTX8

SECISBP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review