RNF181 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	30 studies	26% ± 7%	Explore
macrophage	27 studies	36% ± 14%	Explore
fibroblast	27 studies	27% ± 14%	Explore
classical monocyte	25 studies	36% ± 13%	Explore
endothelial cell	24 studies	30% ± 13%	Explore
conventional dendritic cell	22 studies	35% ± 15%	Explore
non-classical monocyte	22 studies	37% ± 14%	Explore
smooth muscle cell	21 studies	23% ± 9%	Explore
B cell	20 studies	23% ± 6%	Explore
pericyte	20 studies	25% ± 8%	Explore
CD8-positive, alpha-beta T cell	19 studies	28% ± 10%	Explore
regulatory T cell	18 studies	27% ± 10%	Explore
monocyte	17 studies	37% ± 9%	Explore
epithelial cell	17 studies	40% ± 20%	Explore
T cell	16 studies	23% ± 5%	Explore
CD4-positive, alpha-beta T cell	16 studies	26% ± 10%	Explore
dendritic cell	15 studies	34% ± 21%	Explore
mast cell	14 studies	23% ± 5%	Explore
endothelial cell of lymphatic vessel	14 studies	30% ± 11%	Explore
plasma cell	13 studies	40% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	27% ± 7%	Explore
connective tissue cell	13 studies	27% ± 6%	Explore
basal cell	12 studies	35% ± 16%	Explore
plasmacytoid dendritic cell	12 studies	30% ± 11%	Explore
gamma-delta T cell	12 studies	26% ± 14%	Explore
capillary endothelial cell	11 studies	25% ± 7%	Explore
memory B cell	11 studies	23% ± 5%	Explore
myeloid cell	11 studies	33% ± 12%	Explore
naive B cell	10 studies	21% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	28% ± 5%	Explore
mature NK T cell	10 studies	24% ± 4%	Explore
myofibroblast cell	10 studies	24% ± 6%	Explore
endothelial cell of artery	10 studies	25% ± 6%	Explore
vein endothelial cell	10 studies	25% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	27% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	19% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	25% ± 7%	Explore
mucosal invariant T cell	9 studies	21% ± 4%	Explore
secretory cell	8 studies	31% ± 17%	Explore
goblet cell	8 studies	25% ± 12%	Explore
abnormal cell	8 studies	34% ± 17%	Explore
ciliated cell	8 studies	40% ± 14%	Explore
endothelial cell of vascular tree	8 studies	26% ± 6%	Explore
type I pneumocyte	7 studies	34% ± 14%	Explore
plasmablast	7 studies	46% ± 23%	Explore
club cell	7 studies	34% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	24% ± 5%	Explore
epithelial cell of proximal tubule	7 studies	46% ± 14%	Explore
progenitor cell	7 studies	31% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	32% ± 11%	Explore
respiratory goblet cell	6 studies	29% ± 20%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	34% ± 12%	Explore
kidney loop of Henle epithelial cell	6 studies	23% ± 4%	Explore
enterocyte	6 studies	29% ± 5%	Explore
mesothelial cell	6 studies	32% ± 16%	Explore
innate lymphoid cell	6 studies	22% ± 3%	Explore
hematopoietic precursor cell	5 studies	33% ± 11%	Explore
mononuclear phagocyte	5 studies	36% ± 15%	Explore
type II pneumocyte	5 studies	39% ± 18%	Explore
neutrophil	5 studies	22% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	28% ± 13%	Explore
alveolar macrophage	4 studies	28% ± 7%	Explore
leukocyte	4 studies	30% ± 6%	Explore
exhausted T cell	4 studies	39% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	34% ± 8%	Explore
hematopoietic stem cell	4 studies	26% ± 7%	Explore
neuron	4 studies	28% ± 16%	Explore
T follicular helper cell	4 studies	24% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	38% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	31% ± 8%	Explore
enteroendocrine cell	4 studies	30% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	22% ± 5%	Explore
deuterosomal cell	3 studies	39% ± 4%	Explore
duct epithelial cell	3 studies	31% ± 7%	Explore
ionocyte	3 studies	27% ± 5%	Explore
pancreatic A cell	3 studies	38% ± 7%	Explore
type B pancreatic cell	3 studies	39% ± 1%	Explore
renal alpha-intercalated cell	3 studies	32% ± 5%	Explore
neural crest cell	3 studies	17% ± 1%	Explore
extravillous trophoblast	3 studies	42% ± 5%	Explore
placental villous trophoblast	3 studies	38% ± 15%	Explore
common myeloid progenitor	3 studies	38% ± 19%	Explore
erythroblast	3 studies	35% ± 15%	Explore
lymphocyte	3 studies	32% ± 7%	Explore
megakaryocyte	3 studies	24% ± 7%	Explore
neuroendocrine cell	3 studies	25% ± 4%	Explore
immature B cell	3 studies	26% ± 5%	Explore
precursor B cell	3 studies	36% ± 9%	Explore
pro-B cell	3 studies	28% ± 6%	Explore
intraepithelial lymphocyte	3 studies	29% ± 12%	Explore
acinar cell	3 studies	39% ± 18%	Explore
germinal center B cell	3 studies	25% ± 3%	Explore
intermediate monocyte	3 studies	55% ± 8%	Explore
myoepithelial cell	3 studies	23% ± 7%	Explore
pancreatic ductal cell	3 studies	51% ± 12%	Explore
granulocyte monocyte progenitor cell	3 studies	35% ± 11%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	44% ± 26%	Explore
group 3 innate lymphoid cell	3 studies	33% ± 15%	Explore
transit amplifying cell	3 studies	16% ± 1%	Explore
T-helper 1 cell	3 studies	31% ± 12%	Explore
double negative thymocyte	3 studies	38% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	30% ± 13%	Explore
peripheral blood	16 studies	28% ± 7%	Explore
intestine	9 studies	23% ± 10%	Explore
kidney	8 studies	30% ± 4%	Explore
liver	5 studies	28% ± 15%	Explore
pancreas	4 studies	34% ± 11%	Explore
bone marrow	4 studies	23% ± 3%	Explore
uterus	4 studies	29% ± 15%	Explore
lymph node	4 studies	30% ± 17%	Explore
breast	4 studies	21% ± 4%	Explore
placenta	3 studies	42% ± 11%	Explore
adrenal gland	3 studies	20% ± 4%	Explore
thymus	3 studies	35% ± 13%	Explore
brain	3 studies	27% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2162.30	1445 / 1445	100%	100.20	183 / 183
kidney	100%	3371.90	89 / 89	100%	163.13	901 / 901
liver	100%	1964.07	226 / 226	100%	181.36	406 / 406
ovary	100%	1895.46	180 / 180	100%	211.79	430 / 430
pancreas	100%	1935.20	328 / 328	100%	141.93	178 / 178
skin	100%	2302.63	1809 / 1809	100%	144.36	472 / 472
thymus	100%	2277.18	653 / 653	100%	204.94	605 / 605
uterus	100%	2028.88	170 / 170	100%	185.87	459 / 459
brain	100%	1836.97	2640 / 2642	100%	131.73	705 / 705
prostate	100%	2546.41	245 / 245	100%	160.95	501 / 502
lung	100%	2573.13	578 / 578	100%	178.09	1152 / 1155
breast	100%	2424.82	459 / 459	100%	171.86	1114 / 1118
intestine	100%	2062.60	966 / 966	100%	128.95	525 / 527
adrenal gland	100%	2823.91	258 / 258	100%	117.54	229 / 230
stomach	100%	2014.58	359 / 359	99%	117.18	284 / 286
bladder	100%	2420.10	21 / 21	99%	180.80	500 / 504
adipose	100%	2362.81	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2619.80	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	121.17	80 / 80
lymph node	0%	0	0 / 0	100%	245.35	29 / 29
spleen	100%	2232.04	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	157.95	45 / 45
ureter	0%	0	0 / 0	100%	94.48	1 / 1
muscle	100%	2124.36	800 / 803	0%	0	0 / 0
peripheral blood	99%	2591.47	923 / 929	0%	0	0 / 0
heart	99%	1926.79	851 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	RNF181
Protein name	Alternative protein RNF181 Ring finger protein 181 E3 ubiquitin-protein ligase RNF181 (EC 2.3.2.27) (RING finger protein 181)
Synonyms	HSPC238
Description	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates . Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1 . .
Accessions	H7C426 C9J391 Q9P0P0 ENST00000306368.9 ENST00000414390.5 ENST00000443647.5 L8EAW4 F8WBU5 ENST00000456023.1 C9J1C6 ENST00000441634.5

GO_0051865	Biological process	protein autoubiquitination
GO_0016567	Biological process	protein ubiquitination
GO_0005737	Cellular component	cytoplasm
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

RNF181 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review