PSMB3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502Cellular componentproteasome complex
GO_0070062Cellular componentextracellular exosome
GO_0005839Cellular componentproteasome core complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0019774Cellular componentproteasome core complex, beta-subunit complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePSMB3
Protein nameProteasome subunit beta
Proteasome 20S subunit beta 3 (Proteasome subunit beta type-3)
Proteasome subunit beta type-3 (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain)
SynonymshCG_31398
DescriptionFUNCTION: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). .

FUNCTION: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. .

AccessionsENST00000619951.2
P49720
ENST00000613870.4
ENST00000631987.1
A0A087WY10
ENST00000620309.4
ENST00000632832.1
ENST00000619426.5
A0A087WXQ8
A0A384NL22
ENST00000610434.4
ENST00000631787.1
A0A087WUL2