PPA1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	37 studies	35% ± 13%	Explore
endothelial cell	34 studies	39% ± 16%	Explore
CD4-positive, alpha-beta T cell	32 studies	38% ± 17%	Explore
B cell	30 studies	25% ± 8%	Explore
conventional dendritic cell	30 studies	58% ± 17%	Explore
CD8-positive, alpha-beta T cell	28 studies	34% ± 17%	Explore
T cell	27 studies	32% ± 9%	Explore
pericyte	25 studies	34% ± 11%	Explore
dendritic cell	23 studies	55% ± 23%	Explore
regulatory T cell	23 studies	34% ± 13%	Explore
smooth muscle cell	22 studies	30% ± 10%	Explore
basal cell	21 studies	52% ± 17%	Explore
epithelial cell	21 studies	50% ± 21%	Explore
memory B cell	18 studies	24% ± 9%	Explore
natural killer cell	17 studies	25% ± 11%	Explore
monocyte	16 studies	31% ± 10%	Explore
connective tissue cell	16 studies	35% ± 9%	Explore
classical monocyte	15 studies	25% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	36% ± 9%	Explore
gamma-delta T cell	15 studies	27% ± 15%	Explore
macrophage	15 studies	26% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	34% ± 13%	Explore
capillary endothelial cell	14 studies	37% ± 11%	Explore
endothelial cell of artery	14 studies	50% ± 16%	Explore
naive B cell	13 studies	22% ± 5%	Explore
myofibroblast cell	13 studies	31% ± 12%	Explore
astrocyte	13 studies	36% ± 22%	Explore
endothelial cell of vascular tree	13 studies	44% ± 17%	Explore
plasma cell	12 studies	44% ± 16%	Explore
oligodendrocyte	12 studies	31% ± 15%	Explore
mucosal invariant T cell	12 studies	26% ± 6%	Explore
type I pneumocyte	11 studies	46% ± 19%	Explore
type II pneumocyte	11 studies	50% ± 26%	Explore
secretory cell	11 studies	55% ± 20%	Explore
mature NK T cell	11 studies	26% ± 9%	Explore
vein endothelial cell	11 studies	34% ± 12%	Explore
plasmablast	10 studies	52% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	33% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	30% ± 13%	Explore
club cell	10 studies	42% ± 19%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	23% ± 5%	Explore
adipocyte	10 studies	27% ± 6%	Explore
plasmacytoid dendritic cell	10 studies	25% ± 9%	Explore
progenitor cell	9 studies	48% ± 18%	Explore
abnormal cell	9 studies	35% ± 13%	Explore
leukocyte	8 studies	31% ± 10%	Explore
non-classical monocyte	8 studies	27% ± 10%	Explore
neuron	8 studies	43% ± 17%	Explore
goblet cell	8 studies	39% ± 13%	Explore
mesothelial cell	8 studies	30% ± 10%	Explore
retinal rod cell	8 studies	39% ± 18%	Explore
retinal cone cell	8 studies	62% ± 29%	Explore
ciliated cell	8 studies	44% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	37% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	27% ± 5%	Explore
enterocyte	7 studies	38% ± 14%	Explore
transit amplifying cell	7 studies	34% ± 18%	Explore
innate lymphoid cell	7 studies	24% ± 5%	Explore
myeloid cell	7 studies	36% ± 17%	Explore
T follicular helper cell	7 studies	27% ± 4%	Explore
endothelial cell of lymphatic vessel	6 studies	25% ± 9%	Explore
respiratory goblet cell	6 studies	40% ± 24%	Explore
epithelial cell of proximal tubule	6 studies	38% ± 6%	Explore
kidney loop of Henle epithelial cell	6 studies	23% ± 6%	Explore
microglial cell	6 studies	37% ± 22%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	41% ± 13%	Explore
hematopoietic precursor cell	5 studies	44% ± 22%	Explore
ionocyte	5 studies	27% ± 10%	Explore
mononuclear phagocyte	5 studies	38% ± 20%	Explore
intestinal crypt stem cell	5 studies	47% ± 16%	Explore
amacrine cell	5 studies	45% ± 18%	Explore
retinal ganglion cell	5 studies	71% ± 27%	Explore
erythroblast	5 studies	47% ± 9%	Explore
hematopoietic stem cell	5 studies	42% ± 11%	Explore
Mueller cell	5 studies	67% ± 23%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	47% ± 16%	Explore
GABAergic neuron	5 studies	37% ± 11%	Explore
oligodendrocyte precursor cell	5 studies	33% ± 12%	Explore
duct epithelial cell	4 studies	67% ± 9%	Explore
pancreatic A cell	4 studies	65% ± 13%	Explore
type B pancreatic cell	4 studies	62% ± 12%	Explore
monocyte-derived dendritic cell	4 studies	69% ± 20%	Explore
exhausted T cell	4 studies	35% ± 15%	Explore
enteroendocrine cell	4 studies	48% ± 7%	Explore
IgA plasma cell	4 studies	23% ± 10%	Explore
OFF-bipolar cell	4 studies	47% ± 29%	Explore
ON-bipolar cell	4 studies	46% ± 30%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	18% ± 1%	Explore
retina horizontal cell	4 studies	47% ± 17%	Explore
retinal pigment epithelial cell	4 studies	47% ± 13%	Explore
adventitial cell	4 studies	39% ± 6%	Explore
mucus secreting cell	4 studies	47% ± 14%	Explore
CD4-positive helper T cell	4 studies	27% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	61% ± 9%	Explore
glutamatergic neuron	4 studies	49% ± 11%	Explore
hepatocyte	4 studies	53% ± 29%	Explore
T-helper 17 cell	4 studies	45% ± 24%	Explore
interneuron	4 studies	38% ± 17%	Explore
precursor cell	3 studies	52% ± 14%	Explore
pancreatic D cell	3 studies	61% ± 19%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	39% ± 14%	Explore
renal alpha-intercalated cell	3 studies	27% ± 1%	Explore
neural crest cell	3 studies	49% ± 8%	Explore
retinal bipolar neuron	3 studies	56% ± 17%	Explore
GABAergic amacrine cell	3 studies	29% ± 12%	Explore
glycinergic amacrine cell	3 studies	27% ± 10%	Explore
extravillous trophoblast	3 studies	39% ± 3%	Explore
placental villous trophoblast	3 studies	67% ± 15%	Explore
common myeloid progenitor	3 studies	40% ± 19%	Explore
lymphocyte	3 studies	39% ± 12%	Explore
neuroendocrine cell	3 studies	51% ± 16%	Explore
serous secreting cell	3 studies	57% ± 3%	Explore
intraepithelial lymphocyte	3 studies	28% ± 13%	Explore
rod bipolar cell	3 studies	43% ± 13%	Explore
germinal center B cell	3 studies	34% ± 2%	Explore
IgG plasma cell	3 studies	24% ± 9%	Explore
myoepithelial cell	3 studies	33% ± 3%	Explore
luminal cell of prostate epithelium	3 studies	31% ± 8%	Explore
acinar cell	3 studies	63% ± 8%	Explore
pancreatic ductal cell	3 studies	64% ± 5%	Explore
granulocyte monocyte progenitor cell	3 studies	41% ± 3%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	49% ± 17%	Explore
erythrocyte	3 studies	51% ± 25%	Explore
group 3 innate lymphoid cell	3 studies	33% ± 16%	Explore
keratinocyte	3 studies	46% ± 5%	Explore
T-helper 1 cell	3 studies	46% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	21% ± 4%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	34% ± 6%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	28% ± 8%	Explore
double negative thymocyte	3 studies	42% ± 27%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	36% ± 15%	Explore
progenitor cell of mammary luminal epithelium	3 studies	73% ± 20%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	36% ± 13%	Explore
peripheral blood	16 studies	28% ± 9%	Explore
intestine	12 studies	32% ± 11%	Explore
brain	12 studies	31% ± 14%	Explore
eye	10 studies	43% ± 20%	Explore
kidney	7 studies	29% ± 5%	Explore
lymph node	7 studies	29% ± 6%	Explore
liver	7 studies	30% ± 15%	Explore
uterus	6 studies	39% ± 20%	Explore
pancreas	5 studies	54% ± 22%	Explore
bone marrow	5 studies	21% ± 1%	Explore
prostate	4 studies	45% ± 13%	Explore
breast	4 studies	48% ± 11%	Explore
placenta	3 studies	44% ± 10%	Explore
ovary	3 studies	22% ± 5%	Explore
esophagus	3 studies	49% ± 23%	Explore
thymus	3 studies	51% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	100%	3989.01	359 / 359	100%	157.09	286 / 286
esophagus	100%	5314.41	1444 / 1445	100%	99.76	183 / 183
lung	100%	7645.68	577 / 578	100%	107.69	1155 / 1155
intestine	100%	5033.60	966 / 966	100%	188.71	526 / 527
pancreas	100%	5998.57	327 / 328	100%	103.83	178 / 178
brain	100%	7387.14	2636 / 2642	100%	70.13	704 / 705
bladder	100%	4753.67	21 / 21	100%	118.66	502 / 504
thymus	100%	6962.85	653 / 653	100%	89.65	602 / 605
breast	100%	8783.27	459 / 459	99%	107.59	1112 / 1118
ovary	99%	3053.34	179 / 180	100%	133.88	430 / 430
prostate	100%	4012.19	245 / 245	99%	75.23	499 / 502
uterus	99%	3616.43	169 / 170	99%	100.57	455 / 459
adrenal gland	100%	10474.96	258 / 258	96%	88.23	221 / 230
kidney	100%	5399.01	89 / 89	95%	50.15	855 / 901
liver	96%	4134.59	217 / 226	98%	65.84	399 / 406
skin	100%	5364.08	1805 / 1809	92%	51.19	434 / 472
adipose	100%	8772.56	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	144.66	29 / 29
spleen	100%	3208.51	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	77.78	45 / 45
ureter	0%	0	0 / 0	100%	40.92	1 / 1
muscle	100%	4315.78	799 / 803	0%	0	0 / 0
blood vessel	99%	3822.32	1323 / 1335	0%	0	0 / 0
heart	96%	3135.48	828 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	89%	42.45	71 / 80
peripheral blood	39%	3938.43	362 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006796	Biological process	phosphate-containing compound metabolic process
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0004427	Molecular function	inorganic diphosphate phosphatase activity
GO_0000287	Molecular function	magnesium ion binding

Gene name	PPA1
Protein name	Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase)
Synonyms	IOPPP hCG_2024809 HEL-S-66p PP
Description
Accessions	ENST00000373230.7 V9HWB5 ENST00000373232.8 Q5SQT6 ENST00000625364.1 Q15181

PPA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review