POLR2E report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0006362Biological processtranscription elongation by RNA polymerase I
GO_0042797Biological processtRNA transcription by RNA polymerase III
GO_0050821Biological processprotein stabilization
GO_0005736Cellular componentRNA polymerase I complex
GO_0005665Cellular componentRNA polymerase II, core complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005666Cellular componentRNA polymerase III complex
GO_1990062Cellular componentRPAP3/R2TP/prefoldin-like complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0001055Molecular functionRNA polymerase II activity
GO_0001056Molecular functionRNA polymerase III activity
GO_0001054Molecular functionRNA polymerase I activity
GO_0005515Molecular functionprotein binding
GO_0003899Molecular functionDNA-directed 5'-3' RNA polymerase activity

IV. Literature review

[source]
Gene namePOLR2E
Protein namePolymerase (RNA) II (DNA directed) polypeptide E, 25kDa, isoform CRA_c (cDNA FLJ55074, highly similar to DNA-directed RNA polymerase II 23 kDa polypeptide)
DNA-directed RNA polymerase II subunit E (RPB5 homolog)
RNA polymerase II, I and III subunit E
DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (DNA-directed RNA polymerase II 23 kDa polypeptide) (DNA-directed RNA polymerase II subunit E) (RPB5 homolog) (XAP4)
SynonymshCG_21572
DescriptionFUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPABC1 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. .

FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPABC1 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process. .

FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPABC1 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process. .

AccessionsENST00000612655.4
B4DJ89
K7EQN2
ENST00000586746.5
ENST00000589737.5
A0A087WWX0
A0A087WVN5
ENST00000591767.5
K7EJ87
ENST00000585838.2
ENST00000590060.5
ENST00000619917.4
ENST00000215587.11
A0A087WVZ9
ENST00000615234.5
P19388
A0A0A0MQR7