PCMT1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	26 studies	23% ± 6%	Explore
endothelial cell	21 studies	25% ± 11%	Explore
CD8-positive, alpha-beta T cell	19 studies	24% ± 8%	Explore
fibroblast	18 studies	26% ± 10%	Explore
pericyte	18 studies	22% ± 7%	Explore
smooth muscle cell	17 studies	21% ± 6%	Explore
classical monocyte	17 studies	24% ± 10%	Explore
T cell	16 studies	21% ± 6%	Explore
CD4-positive, alpha-beta T cell	16 studies	24% ± 9%	Explore
regulatory T cell	16 studies	22% ± 6%	Explore
non-classical monocyte	15 studies	29% ± 12%	Explore
mast cell	13 studies	25% ± 6%	Explore
macrophage	13 studies	25% ± 9%	Explore
monocyte	13 studies	24% ± 6%	Explore
mature NK T cell	11 studies	22% ± 4%	Explore
B cell	11 studies	19% ± 6%	Explore
glutamatergic neuron	11 studies	42% ± 23%	Explore
gamma-delta T cell	11 studies	23% ± 12%	Explore
plasma cell	9 studies	27% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	21% ± 5%	Explore
conventional dendritic cell	9 studies	29% ± 15%	Explore
neuron	9 studies	40% ± 16%	Explore
oligodendrocyte	9 studies	28% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	21% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	21% ± 4%	Explore
connective tissue cell	8 studies	26% ± 9%	Explore
endothelial cell of vascular tree	8 studies	19% ± 4%	Explore
astrocyte	8 studies	30% ± 13%	Explore
mucosal invariant T cell	8 studies	18% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	23% ± 6%	Explore
platelet	7 studies	25% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	22% ± 4%	Explore
basal cell	7 studies	36% ± 16%	Explore
ciliated cell	7 studies	35% ± 12%	Explore
GABAergic neuron	7 studies	41% ± 18%	Explore
oligodendrocyte precursor cell	7 studies	25% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	19% ± 1%	Explore
myofibroblast cell	6 studies	26% ± 5%	Explore
epithelial cell	6 studies	44% ± 17%	Explore
innate lymphoid cell	6 studies	20% ± 2%	Explore
myeloid cell	6 studies	24% ± 10%	Explore
capillary endothelial cell	6 studies	19% ± 3%	Explore
T follicular helper cell	6 studies	16% ± 1%	Explore
memory B cell	6 studies	18% ± 2%	Explore
goblet cell	6 studies	27% ± 13%	Explore
plasmacytoid dendritic cell	6 studies	24% ± 7%	Explore
hematopoietic precursor cell	5 studies	31% ± 12%	Explore
plasmablast	5 studies	42% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	31% ± 7%	Explore
mononuclear phagocyte	5 studies	24% ± 11%	Explore
endothelial cell of artery	5 studies	18% ± 2%	Explore
retinal ganglion cell	5 studies	73% ± 26%	Explore
endothelial cell of lymphatic vessel	5 studies	27% ± 9%	Explore
dendritic cell	5 studies	32% ± 19%	Explore
erythrocyte	5 studies	34% ± 20%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	24% ± 9%	Explore
abnormal cell	5 studies	28% ± 9%	Explore
interneuron	5 studies	39% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	24% ± 6%	Explore
pancreatic A cell	4 studies	44% ± 17%	Explore
leukocyte	4 studies	23% ± 7%	Explore
naive B cell	4 studies	20% ± 4%	Explore
exhausted T cell	4 studies	28% ± 6%	Explore
lymphocyte	4 studies	22% ± 8%	Explore
amacrine cell	4 studies	39% ± 16%	Explore
retina horizontal cell	4 studies	37% ± 15%	Explore
microglial cell	4 studies	22% ± 6%	Explore
alveolar macrophage	4 studies	21% ± 5%	Explore
erythroblast	4 studies	39% ± 27%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	29% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	21% ± 5%	Explore
type B pancreatic cell	3 studies	57% ± 10%	Explore
progenitor cell	3 studies	19% ± 1%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	19% ± 2%	Explore
neural crest cell	3 studies	20% ± 3%	Explore
vein endothelial cell	3 studies	15% ± 0%	Explore
retinal bipolar neuron	3 studies	32% ± 11%	Explore
extravillous trophoblast	3 studies	25% ± 5%	Explore
placental villous trophoblast	3 studies	28% ± 8%	Explore
club cell	3 studies	24% ± 6%	Explore
pro-B cell	3 studies	21% ± 4%	Explore
retinal cone cell	3 studies	32% ± 11%	Explore
retinal rod cell	3 studies	25% ± 5%	Explore
Mueller cell	3 studies	32% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	24% ± 3%	Explore
type I pneumocyte	3 studies	30% ± 8%	Explore
type II pneumocyte	3 studies	27% ± 12%	Explore
pancreatic ductal cell	3 studies	36% ± 10%	Explore
megakaryocyte	3 studies	35% ± 3%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	38% ± 24%	Explore
enteroendocrine cell	3 studies	33% ± 20%	Explore
intestinal crypt stem cell	3 studies	20% ± 3%	Explore
glial cell	3 studies	30% ± 17%	Explore
group 3 innate lymphoid cell	3 studies	26% ± 13%	Explore
melanocyte	3 studies	20% ± 4%	Explore
transit amplifying cell	3 studies	27% ± 8%	Explore
T-helper 17 cell	3 studies	29% ± 14%	Explore
hepatocyte	3 studies	39% ± 15%	Explore
double negative thymocyte	3 studies	33% ± 17%	Explore
hematopoietic stem cell	3 studies	22% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	32% ± 18%	Explore
peripheral blood	12 studies	24% ± 5%	Explore
lung	10 studies	29% ± 12%	Explore
eye	6 studies	30% ± 8%	Explore
liver	6 studies	31% ± 23%	Explore
kidney	5 studies	19% ± 2%	Explore
bone marrow	4 studies	19% ± 3%	Explore
intestine	4 studies	24% ± 12%	Explore
pancreas	3 studies	51% ± 8%	Explore
lymph node	3 studies	20% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2993.28	1445 / 1445	100%	52.33	183 / 183
ovary	100%	2301.23	180 / 180	100%	46.46	430 / 430
stomach	100%	2191.90	359 / 359	100%	53.30	286 / 286
breast	100%	3312.98	459 / 459	100%	87.61	1116 / 1118
bladder	100%	2923.48	21 / 21	100%	55.97	503 / 504
uterus	100%	2961.89	170 / 170	100%	67.30	458 / 459
brain	100%	6626.35	2636 / 2642	100%	111.37	705 / 705
intestine	100%	2992.60	966 / 966	100%	59.74	525 / 527
thymus	100%	2614.45	651 / 653	100%	70.59	603 / 605
lung	99%	2685.84	574 / 578	100%	53.02	1155 / 1155
skin	100%	3575.76	1807 / 1809	99%	78.05	469 / 472
prostate	100%	2498.60	244 / 245	99%	68.16	499 / 502
liver	99%	2009.52	224 / 226	99%	34.09	403 / 406
kidney	100%	2219.30	89 / 89	98%	41.68	882 / 901
adrenal gland	100%	2661.50	257 / 258	97%	82.05	224 / 230
pancreas	96%	1471.45	314 / 328	100%	45.41	178 / 178
adipose	100%	3346.76	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	66.56	29 / 29
muscle	100%	9466.36	803 / 803	0%	0	0 / 0
spleen	100%	2455.26	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	59.49	45 / 45
ureter	0%	0	0 / 0	100%	13.79	1 / 1
blood vessel	100%	3518.78	1332 / 1335	0%	0	0 / 0
heart	95%	4282.72	821 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	42.49	76 / 80
peripheral blood	94%	3134.71	875 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	PCMT1
Protein name	Protein-L-isoaspartate O-methyltransferase (EC 2.1.1.77) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) Protein-L-isoaspartate (D-aspartate) O-methyltransferase
Synonyms
Description	FUNCTION: Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins . Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity). .
Accessions	P22061 ENST00000367384.8 [P22061-2] F8WAV5 F8WAX2 F6S8N6 ENST00000494411.6 C9J0F2 A0A3F2YNX8 F8WDT3 ENST00000460828.6 H7C4X2 ENST00000484601.6 ENST00000486585.2 ENST00000544496.5 ENST00000367378.6 [P22061-1] ENST00000495487.1 ENST00000464889.7 [P22061-1] ENST00000367380.9

GO_0006479	Biological process	protein methylation
GO_0030091	Biological process	protein repair
GO_1903561	Cellular component	extracellular vesicle
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0045296	Molecular function	cadherin binding
GO_0004719	Molecular function	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO_0005515	Molecular function	protein binding

PCMT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review