NKTR | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	51 studies	45% ± 17%	Explore
B cell	37 studies	30% ± 11%	Explore
fibroblast	36 studies	33% ± 14%	Explore
natural killer cell	35 studies	30% ± 11%	Explore
T cell	31 studies	31% ± 11%	Explore
pericyte	29 studies	31% ± 13%	Explore
CD4-positive, alpha-beta T cell	27 studies	32% ± 12%	Explore
CD8-positive, alpha-beta T cell	27 studies	31% ± 11%	Explore
smooth muscle cell	26 studies	28% ± 9%	Explore
macrophage	25 studies	30% ± 15%	Explore
regulatory T cell	25 studies	30% ± 10%	Explore
endothelial cell of lymphatic vessel	23 studies	45% ± 17%	Explore
astrocyte	22 studies	44% ± 16%	Explore
mast cell	21 studies	28% ± 10%	Explore
memory B cell	19 studies	27% ± 7%	Explore
naive B cell	18 studies	27% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	33% ± 12%	Explore
non-classical monocyte	17 studies	35% ± 19%	Explore
oligodendrocyte precursor cell	17 studies	42% ± 19%	Explore
oligodendrocyte	16 studies	48% ± 17%	Explore
mature NK T cell	16 studies	29% ± 9%	Explore
capillary endothelial cell	16 studies	37% ± 9%	Explore
gamma-delta T cell	16 studies	33% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	30% ± 10%	Explore
ciliated cell	15 studies	29% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	33% ± 12%	Explore
vein endothelial cell	15 studies	44% ± 19%	Explore
basal cell	14 studies	35% ± 19%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	30% ± 11%	Explore
endothelial cell of artery	14 studies	40% ± 14%	Explore
epithelial cell	14 studies	40% ± 22%	Explore
microglial cell	14 studies	46% ± 14%	Explore
mucosal invariant T cell	14 studies	28% ± 6%	Explore
monocyte	13 studies	28% ± 11%	Explore
classical monocyte	13 studies	26% ± 14%	Explore
glutamatergic neuron	13 studies	50% ± 23%	Explore
myofibroblast cell	13 studies	30% ± 10%	Explore
type I pneumocyte	12 studies	34% ± 11%	Explore
plasma cell	12 studies	29% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	32% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	33% ± 8%	Explore
conventional dendritic cell	12 studies	27% ± 18%	Explore
connective tissue cell	12 studies	31% ± 11%	Explore
plasmacytoid dendritic cell	12 studies	29% ± 9%	Explore
endothelial cell of vascular tree	12 studies	33% ± 18%	Explore
dendritic cell	11 studies	37% ± 19%	Explore
GABAergic neuron	11 studies	52% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	37% ± 15%	Explore
adipocyte	10 studies	35% ± 11%	Explore
leukocyte	9 studies	43% ± 14%	Explore
neuron	9 studies	48% ± 21%	Explore
mesothelial cell	9 studies	37% ± 13%	Explore
myeloid cell	9 studies	30% ± 7%	Explore
type II pneumocyte	8 studies	36% ± 11%	Explore
progenitor cell	8 studies	32% ± 9%	Explore
amacrine cell	8 studies	42% ± 9%	Explore
retinal rod cell	8 studies	34% ± 4%	Explore
goblet cell	7 studies	33% ± 25%	Explore
club cell	7 studies	33% ± 13%	Explore
retinal cone cell	7 studies	33% ± 12%	Explore
T follicular helper cell	7 studies	32% ± 9%	Explore
hematopoietic precursor cell	6 studies	38% ± 23%	Explore
respiratory goblet cell	6 studies	35% ± 13%	Explore
plasmablast	6 studies	38% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	23% ± 5%	Explore
interneuron	6 studies	62% ± 19%	Explore
retinal ganglion cell	6 studies	38% ± 12%	Explore
lymphocyte	6 studies	47% ± 19%	Explore
precursor B cell	6 studies	28% ± 7%	Explore
retina horizontal cell	6 studies	43% ± 9%	Explore
Mueller cell	6 studies	51% ± 12%	Explore
innate lymphoid cell	6 studies	29% ± 8%	Explore
secretory cell	5 studies	28% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	27% ± 8%	Explore
mononuclear phagocyte	5 studies	27% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	26% ± 9%	Explore
abnormal cell	5 studies	40% ± 16%	Explore
retinal bipolar neuron	5 studies	41% ± 7%	Explore
hematopoietic stem cell	5 studies	30% ± 7%	Explore
pro-B cell	5 studies	32% ± 2%	Explore
cardiac muscle cell	5 studies	32% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	42% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	28% ± 8%	Explore
pancreatic A cell	4 studies	35% ± 17%	Explore
exhausted T cell	4 studies	36% ± 22%	Explore
renal alpha-intercalated cell	4 studies	30% ± 11%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	43% ± 15%	Explore
glial cell	4 studies	39% ± 13%	Explore
granule cell	4 studies	46% ± 5%	Explore
brush cell	4 studies	31% ± 4%	Explore
immature B cell	4 studies	27% ± 3%	Explore
retinal pigment epithelial cell	4 studies	44% ± 27%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	23% ± 4%	Explore
hepatocyte	4 studies	57% ± 13%	Explore
transit amplifying cell	4 studies	37% ± 34%	Explore
double negative thymocyte	4 studies	43% ± 17%	Explore
ionocyte	3 studies	35% ± 6%	Explore
pancreatic D cell	3 studies	30% ± 21%	Explore
type B pancreatic cell	3 studies	40% ± 15%	Explore
glomerular endothelial cell	3 studies	54% ± 13%	Explore
epithelial cell of proximal tubule	3 studies	33% ± 10%	Explore
renal beta-intercalated cell	3 studies	38% ± 7%	Explore
neural crest cell	3 studies	29% ± 0%	Explore
GABAergic interneuron	3 studies	52% ± 2%	Explore
enterocyte	3 studies	18% ± 2%	Explore
GABAergic amacrine cell	3 studies	42% ± 8%	Explore
OFF-bipolar cell	3 studies	37% ± 7%	Explore
ON-bipolar cell	3 studies	42% ± 6%	Explore
glycinergic amacrine cell	3 studies	37% ± 3%	Explore
rod bipolar cell	3 studies	44% ± 7%	Explore
erythroblast	3 studies	28% ± 10%	Explore
germinal center B cell	3 studies	29% ± 6%	Explore
CD4-positive helper T cell	3 studies	37% ± 8%	Explore
muscle cell	3 studies	40% ± 25%	Explore
pancreatic ductal cell	3 studies	34% ± 15%	Explore
ependymal cell	3 studies	55% ± 11%	Explore
enteroendocrine cell	3 studies	34% ± 11%	Explore
adventitial cell	3 studies	29% ± 6%	Explore
alveolar macrophage	3 studies	40% ± 12%	Explore
chondrocyte	3 studies	52% ± 10%	Explore
group 3 innate lymphoid cell	3 studies	42% ± 10%	Explore
Schwann cell	3 studies	37% ± 20%	Explore
T-helper 17 cell	3 studies	30% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	32% ± 7%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	28% ± 7%	Explore
kidney loop of Henle epithelial cell	3 studies	32% ± 11%	Explore
renal principal cell	3 studies	26% ± 7%	Explore
mural cell	3 studies	56% ± 11%	Explore
mucus secreting cell	3 studies	39% ± 9%	Explore
erythrocyte	3 studies	27% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	20 studies	47% ± 21%	Explore
lung	16 studies	31% ± 10%	Explore
peripheral blood	16 studies	31% ± 14%	Explore
eye	10 studies	41% ± 16%	Explore
kidney	8 studies	28% ± 9%	Explore
intestine	8 studies	28% ± 12%	Explore
heart	5 studies	33% ± 5%	Explore
liver	5 studies	40% ± 13%	Explore
bone marrow	4 studies	26% ± 7%	Explore
uterus	4 studies	30% ± 15%	Explore
breast	4 studies	24% ± 4%	Explore
lymph node	4 studies	25% ± 7%	Explore
adipose	4 studies	39% ± 11%	Explore
pancreas	3 studies	37% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	11051.69	1442 / 1445	100%	15.21	183 / 183
breast	100%	18279.15	459 / 459	99%	16.66	1106 / 1118
prostate	100%	14922.07	245 / 245	99%	14.39	495 / 502
thymus	100%	19608.86	653 / 653	98%	16.38	592 / 605
bladder	100%	13085.00	21 / 21	97%	12.97	490 / 504
pancreas	100%	7886.41	328 / 328	97%	13.48	173 / 178
lung	100%	17112.17	578 / 578	97%	12.46	1115 / 1155
uterus	100%	18782.78	170 / 170	96%	12.93	440 / 459
adrenal gland	100%	10406.81	258 / 258	96%	9.28	220 / 230
intestine	100%	13294.95	965 / 966	95%	10.48	499 / 527
brain	95%	8123.01	2510 / 2642	99%	18.40	701 / 705
stomach	100%	9553.84	359 / 359	94%	10.72	270 / 286
kidney	100%	8474.92	89 / 89	92%	11.02	833 / 901
ovary	100%	19069.65	180 / 180	92%	7.84	396 / 430
skin	100%	12247.19	1809 / 1809	89%	10.95	420 / 472
liver	100%	5621.85	226 / 226	71%	5.16	289 / 406
spleen	100%	18513.56	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	6.36	1 / 1
adipose	100%	15729.89	1203 / 1204	0%	0	0 / 0
blood vessel	100%	11635.31	1333 / 1335	0%	0	0 / 0
heart	99%	7059.40	854 / 861	0%	0	0 / 0
muscle	98%	5822.02	787 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	89%	9.13	40 / 45
lymph node	0%	0	0 / 0	86%	12.09	25 / 29
peripheral blood	57%	4731.68	528 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	51%	4.16	41 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	NKTR
Protein name	Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase)
Synonyms
Description	FUNCTION: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding . Component of a putative tumor-recognition complex involved in the function of NK cells . . FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. . FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. .
Accessions	P30414 ENST00000232978.13 ENST00000429888.5 C9JMM5 ENST00000442970.5 ENST00000445842.1 A8K7K2

GO_0006457	Biological process	protein folding
GO_0000413	Biological process	protein peptidyl-prolyl isomerization
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0005634	Cellular component	nucleus
GO_0016018	Molecular function	cyclosporin A binding
GO_0003755	Molecular function	peptidyl-prolyl cis-trans isomerase activity

NKTR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review