MPHOSPH8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0045869Biological processnegative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO_0090309Biological processpositive regulation of DNA methylation-dependent heterochromatin formation
GO_0044027Biological processnegative regulation of gene expression via chromosomal CpG island methylation
GO_0000792Cellular componentheterochromatin
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0000786Cellular componentnucleosome
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0140566Molecular functionhistone reader activity
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameMPHOSPH8
Protein nameM-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3)
M-phase phosphoprotein 8
SynonymsMPP8
DescriptionFUNCTION: Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression . Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 . Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene . Mediates down-regulation of CDH1 expression . Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression . The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed . .

AccessionsENST00000449056.1
Q99549
ENST00000414242.3
H0Y6J1
ENST00000361479.10 [Q99549-1]
A0A0A0MT47