KMT2C | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	34 studies	43% ± 18%	Explore
macrophage	29 studies	37% ± 21%	Explore
fibroblast	24 studies	36% ± 18%	Explore
B cell	22 studies	29% ± 12%	Explore
natural killer cell	20 studies	26% ± 11%	Explore
classical monocyte	20 studies	29% ± 10%	Explore
non-classical monocyte	19 studies	29% ± 12%	Explore
astrocyte	19 studies	60% ± 19%	Explore
smooth muscle cell	18 studies	33% ± 15%	Explore
monocyte	17 studies	34% ± 20%	Explore
pericyte	16 studies	39% ± 18%	Explore
CD8-positive, alpha-beta T cell	16 studies	23% ± 8%	Explore
microglial cell	16 studies	60% ± 17%	Explore
T cell	15 studies	30% ± 12%	Explore
oligodendrocyte	15 studies	59% ± 16%	Explore
oligodendrocyte precursor cell	15 studies	62% ± 18%	Explore
mast cell	13 studies	35% ± 16%	Explore
CD4-positive, alpha-beta T cell	13 studies	26% ± 9%	Explore
basal cell	12 studies	37% ± 20%	Explore
ciliated cell	12 studies	30% ± 14%	Explore
glutamatergic neuron	12 studies	59% ± 22%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	26% ± 8%	Explore
memory B cell	12 studies	20% ± 3%	Explore
dendritic cell	11 studies	44% ± 19%	Explore
endothelial cell of lymphatic vessel	11 studies	38% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	25% ± 6%	Explore
epithelial cell	11 studies	46% ± 24%	Explore
plasmacytoid dendritic cell	11 studies	22% ± 7%	Explore
GABAergic neuron	11 studies	57% ± 21%	Explore
myeloid cell	11 studies	43% ± 17%	Explore
naive B cell	10 studies	23% ± 4%	Explore
conventional dendritic cell	10 studies	26% ± 14%	Explore
gamma-delta T cell	10 studies	23% ± 7%	Explore
type I pneumocyte	9 studies	44% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	26% ± 8%	Explore
mature NK T cell	9 studies	23% ± 10%	Explore
capillary endothelial cell	9 studies	26% ± 13%	Explore
mucosal invariant T cell	9 studies	24% ± 7%	Explore
regulatory T cell	9 studies	27% ± 8%	Explore
adipocyte	9 studies	53% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	25% ± 4%	Explore
club cell	8 studies	41% ± 19%	Explore
leukocyte	8 studies	41% ± 22%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	25% ± 9%	Explore
type II pneumocyte	7 studies	42% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	19% ± 3%	Explore
abnormal cell	7 studies	29% ± 18%	Explore
neuron	7 studies	54% ± 22%	Explore
amacrine cell	7 studies	42% ± 19%	Explore
retinal cone cell	7 studies	48% ± 23%	Explore
endothelial cell of artery	7 studies	26% ± 8%	Explore
mesothelial cell	7 studies	44% ± 13%	Explore
respiratory goblet cell	6 studies	48% ± 19%	Explore
interneuron	6 studies	67% ± 15%	Explore
retinal ganglion cell	6 studies	53% ± 28%	Explore
retina horizontal cell	6 studies	48% ± 26%	Explore
vein endothelial cell	6 studies	33% ± 19%	Explore
Mueller cell	6 studies	50% ± 26%	Explore
innate lymphoid cell	6 studies	24% ± 10%	Explore
goblet cell	6 studies	36% ± 28%	Explore
secretory cell	5 studies	25% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	21% ± 5%	Explore
mononuclear phagocyte	5 studies	33% ± 15%	Explore
retinal bipolar neuron	5 studies	36% ± 21%	Explore
glial cell	5 studies	36% ± 14%	Explore
brush cell	5 studies	46% ± 12%	Explore
cardiac muscle cell	5 studies	47% ± 13%	Explore
lymphocyte	5 studies	43% ± 20%	Explore
endothelial cell of vascular tree	5 studies	38% ± 20%	Explore
myofibroblast cell	5 studies	34% ± 20%	Explore
connective tissue cell	5 studies	33% ± 13%	Explore
alveolar macrophage	5 studies	46% ± 24%	Explore
neutrophil	4 studies	27% ± 11%	Explore
squamous epithelial cell	4 studies	38% ± 21%	Explore
granule cell	4 studies	55% ± 1%	Explore
progenitor cell	4 studies	45% ± 22%	Explore
precursor B cell	4 studies	21% ± 5%	Explore
plasma cell	4 studies	51% ± 8%	Explore
immature B cell	4 studies	21% ± 5%	Explore
retinal pigment epithelial cell	4 studies	51% ± 27%	Explore
OFF-bipolar cell	4 studies	47% ± 24%	Explore
ON-bipolar cell	4 studies	47% ± 24%	Explore
retinal rod cell	4 studies	53% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	22% ± 7%	Explore
hepatocyte	4 studies	63% ± 20%	Explore
ionocyte	3 studies	35% ± 5%	Explore
cholangiocyte	3 studies	45% ± 19%	Explore
hematopoietic precursor cell	3 studies	43% ± 22%	Explore
plasmablast	3 studies	38% ± 6%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	65% ± 5%	Explore
GABAergic interneuron	3 studies	57% ± 9%	Explore
megakaryocyte	3 studies	39% ± 22%	Explore
GABAergic amacrine cell	3 studies	62% ± 16%	Explore
glycinergic amacrine cell	3 studies	54% ± 12%	Explore
rod bipolar cell	3 studies	51% ± 22%	Explore
erythroblast	3 studies	23% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	23% ± 6%	Explore
neural progenitor cell	3 studies	54% ± 27%	Explore
ependymal cell	3 studies	60% ± 17%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	41% ± 16%	Explore
enteroendocrine cell	3 studies	29% ± 7%	Explore
adventitial cell	3 studies	32% ± 12%	Explore
group 3 innate lymphoid cell	3 studies	33% ± 8%	Explore
muscle cell	3 studies	53% ± 22%	Explore
kidney loop of Henle epithelial cell	3 studies	36% ± 17%	Explore
renal principal cell	3 studies	41% ± 19%	Explore
mural cell	3 studies	58% ± 6%	Explore
mucus secreting cell	3 studies	55% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	57% ± 19%	Explore
peripheral blood	13 studies	24% ± 8%	Explore
lung	11 studies	34% ± 15%	Explore
eye	8 studies	46% ± 25%	Explore
heart	5 studies	40% ± 13%	Explore
kidney	5 studies	34% ± 15%	Explore
liver	4 studies	40% ± 15%	Explore
adipose	4 studies	44% ± 16%	Explore
bone marrow	3 studies	30% ± 18%	Explore
intestine	3 studies	21% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6893.96	1445 / 1445	100%	21.32	183 / 183
brain	100%	5780.37	2636 / 2642	100%	25.45	702 / 705
breast	100%	7462.38	459 / 459	99%	23.64	1109 / 1118
lung	100%	7393.99	578 / 578	99%	15.88	1143 / 1155
thymus	100%	8508.49	653 / 653	99%	18.68	598 / 605
ovary	100%	8372.08	180 / 180	99%	15.42	425 / 430
prostate	100%	5582.94	245 / 245	99%	17.82	496 / 502
intestine	100%	6970.91	966 / 966	98%	12.97	516 / 527
pancreas	100%	5446.12	328 / 328	98%	12.85	174 / 178
stomach	100%	6266.65	359 / 359	98%	15.83	279 / 286
kidney	100%	3667.01	89 / 89	97%	13.76	878 / 901
adrenal gland	100%	5757.72	258 / 258	97%	12.01	224 / 230
bladder	100%	6231.24	21 / 21	97%	11.48	489 / 504
skin	100%	8233.82	1809 / 1809	97%	12.74	456 / 472
uterus	100%	8184.40	170 / 170	95%	11.53	437 / 459
liver	100%	2734.55	226 / 226	75%	5.50	305 / 406
adipose	100%	6737.65	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7119.88	1335 / 1335	0%	0	0 / 0
muscle	100%	8375.25	803 / 803	0%	0	0 / 0
spleen	100%	6186.66	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	4.03	1 / 1
heart	96%	3623.77	824 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	11.47	42 / 45
eye	0%	0	0 / 0	86%	7.02	69 / 80
lymph node	0%	0	0 / 0	83%	8.54	24 / 29
peripheral blood	81%	4364.96	752 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0032259	Biological process	methylation
GO_0051602	Biological process	response to electrical stimulus
GO_0006338	Biological process	chromatin remodeling
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0035097	Cellular component	histone methyltransferase complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0044666	Cellular component	MLL3/4 complex
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0042800	Molecular function	histone H3K4 methyltransferase activity
GO_0016746	Molecular function	acyltransferase activity
GO_0042054	Molecular function	histone methyltransferase activity
GO_0046872	Molecular function	metal ion binding
GO_0003723	Molecular function	RNA binding
GO_0140999	Molecular function	histone H3K4 trimethyltransferase activity
GO_0140945	Molecular function	histone H3K4 monomethyltransferase activity
GO_0003713	Molecular function	transcription coactivator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	KMT2C
Protein name	Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) Lysine methyltransferase 2C [histone H3]-lysine(4) N-methyltransferase (EC 2.1.1.364)
Synonyms	KIAA1506 HALR MLL3
Description	FUNCTION: Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) . Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place . Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements . .
Accessions	H7C2V8 ENST00000262189.11 [Q8NEZ4-1] A0A804HKQ3 A0A804HJT1 H7BY37 ENST00000684550.1 H0YNL4 A0A804HJV8 A0A804HJU5 ENST00000682283.1 [Q8NEZ4-3] ENST00000683670.1 ENST00000679645.1 ENST00000360104.8 A0A804HLD4 A0A804HIS4 A0A804HJ77 A0A804HJ27 ENST00000682176.1 ENST00000680039.1 A0A7P0TBM6 ENST00000681082.1 A0A7P0TAQ8 ENST00000683502.1 ENST00000683178.1 ENST00000418061.2 ENST00000680029.1 ENST00000418673.2 A0A804HKW4 ENST00000684307.1 A0A7P0Z448 ENST00000679560.1 ENST00000683616.1 A0A7P0T9K8 ENST00000683625.1 ENST00000683200.1 ENST00000424877.6 ENST00000684140.1 A0A7P0T9U9 A0A7P0T8F0 A0A7P0T9N3 A0A804HI08 A0A7P0T9Q7 A0A804HIW6 ENST00000684398.1 ENST00000679882.1 A0A804HLA5 A0A7P0TA60 A0A804HKJ1 H0Y765 ENST00000681838.1 ENST00000684069.1 C9J4Z5 ENST00000681033.1 ENST00000452749.2 A0A804HIK3 H7C212 A0A7P0TAI3 ENST00000680877.1 ENST00000683490.1 A0A804HK48 A0A804HIM6 ENST00000558665.2 ENST00000684649.1 ENST00000683397.1 A0A804HIF3 ENST00000682916.1 ENST00000684262.1 Q8NEZ4 ENST00000682040.1 A0A804HIM1 ENST00000682301.1 ENST00000684278.1 A0A804HIG3 A0A804HHW0 ENST00000683159.1 ENST00000684261.1 A0A804HJR9 ENST00000680969.1 A0A804HKS3

KMT2C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review