HNRNPL | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	23 studies	24% ± 7%	Explore
B cell	19 studies	24% ± 8%	Explore
CD8-positive, alpha-beta T cell	17 studies	24% ± 6%	Explore
CD4-positive, alpha-beta T cell	16 studies	23% ± 5%	Explore
T cell	15 studies	22% ± 5%	Explore
endothelial cell	15 studies	24% ± 6%	Explore
regulatory T cell	15 studies	22% ± 8%	Explore
naive B cell	13 studies	24% ± 8%	Explore
memory B cell	12 studies	23% ± 6%	Explore
plasmacytoid dendritic cell	12 studies	26% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	27% ± 9%	Explore
classical monocyte	12 studies	24% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	23% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	25% ± 9%	Explore
mature NK T cell	10 studies	20% ± 3%	Explore
gamma-delta T cell	10 studies	29% ± 12%	Explore
fibroblast	10 studies	24% ± 5%	Explore
conventional dendritic cell	9 studies	30% ± 17%	Explore
pericyte	9 studies	21% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	22% ± 7%	Explore
basal cell	7 studies	27% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	19% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	23% ± 7%	Explore
non-classical monocyte	7 studies	27% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	23% ± 8%	Explore
dendritic cell	7 studies	44% ± 26%	Explore
myofibroblast cell	7 studies	27% ± 7%	Explore
epithelial cell	7 studies	40% ± 19%	Explore
mucosal invariant T cell	6 studies	26% ± 6%	Explore
precursor B cell	6 studies	35% ± 14%	Explore
smooth muscle cell	6 studies	21% ± 4%	Explore
macrophage	6 studies	23% ± 6%	Explore
oligodendrocyte	6 studies	26% ± 8%	Explore
hematopoietic precursor cell	5 studies	33% ± 15%	Explore
plasmablast	5 studies	41% ± 15%	Explore
microglial cell	5 studies	21% ± 3%	Explore
pro-B cell	5 studies	38% ± 13%	Explore
mast cell	5 studies	24% ± 13%	Explore
ciliated cell	5 studies	29% ± 12%	Explore
immature B cell	5 studies	34% ± 7%	Explore
oligodendrocyte precursor cell	5 studies	29% ± 8%	Explore
goblet cell	5 studies	26% ± 6%	Explore
secretory cell	4 studies	24% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	19% ± 2%	Explore
leukocyte	4 studies	20% ± 2%	Explore
capillary endothelial cell	4 studies	19% ± 5%	Explore
glutamatergic neuron	4 studies	29% ± 13%	Explore
lymphocyte	4 studies	26% ± 7%	Explore
myeloid cell	4 studies	41% ± 13%	Explore
endothelial cell of lymphatic vessel	4 studies	21% ± 2%	Explore
neuron	4 studies	31% ± 10%	Explore
type I pneumocyte	4 studies	22% ± 3%	Explore
adipocyte	4 studies	23% ± 3%	Explore
T follicular helper cell	4 studies	26% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	26% ± 7%	Explore
innate lymphoid cell	4 studies	21% ± 4%	Explore
abnormal cell	4 studies	28% ± 6%	Explore
enteroendocrine cell	4 studies	23% ± 5%	Explore
monocyte	4 studies	21% ± 5%	Explore
astrocyte	4 studies	25% ± 8%	Explore
plasma cell	3 studies	33% ± 16%	Explore
exhausted T cell	3 studies	21% ± 4%	Explore
amacrine cell	3 studies	22% ± 5%	Explore
retinal bipolar neuron	3 studies	18% ± 1%	Explore
erythroblast	3 studies	41% ± 22%	Explore
hematopoietic stem cell	3 studies	25% ± 8%	Explore
connective tissue cell	3 studies	34% ± 18%	Explore
type II pneumocyte	3 studies	20% ± 3%	Explore
endothelial cell of vascular tree	3 studies	18% ± 3%	Explore
intestinal crypt stem cell	3 studies	21% ± 5%	Explore
erythrocyte	3 studies	33% ± 9%	Explore
group 3 innate lymphoid cell	3 studies	34% ± 8%	Explore
transit amplifying cell	3 studies	30% ± 9%	Explore
T-helper 1 cell	3 studies	21% ± 7%	Explore
T-helper 17 cell	3 studies	19% ± 2%	Explore
GABAergic neuron	3 studies	29% ± 11%	Explore
interneuron	3 studies	33% ± 18%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	11 studies	27% ± 12%	Explore
lung	8 studies	23% ± 10%	Explore
brain	7 studies	26% ± 9%	Explore
intestine	5 studies	21% ± 4%	Explore
bone marrow	3 studies	27% ± 12%	Explore
eye	3 studies	21% ± 4%	Explore
liver	3 studies	25% ± 5%	Explore
lymph node	3 studies	19% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	12572.82	459 / 459	100%	81.86	1118 / 1118
esophagus	100%	11512.99	1445 / 1445	100%	80.47	183 / 183
intestine	100%	12529.32	966 / 966	100%	83.88	527 / 527
lung	100%	12883.65	578 / 578	100%	79.00	1155 / 1155
ovary	100%	11984.46	180 / 180	100%	92.90	430 / 430
pancreas	100%	6236.19	328 / 328	100%	64.11	178 / 178
prostate	100%	10779.61	245 / 245	100%	72.44	502 / 502
skin	100%	14946.06	1809 / 1809	100%	73.97	472 / 472
stomach	100%	9438.97	359 / 359	100%	82.93	286 / 286
uterus	100%	13219.37	170 / 170	100%	88.58	459 / 459
thymus	100%	13575.15	653 / 653	100%	70.80	604 / 605
bladder	100%	10885.90	21 / 21	100%	80.16	503 / 504
liver	100%	6610.81	226 / 226	100%	39.27	405 / 406
kidney	100%	9474.80	89 / 89	100%	49.81	897 / 901
brain	100%	7922.54	2630 / 2642	100%	65.95	705 / 705
adrenal gland	100%	11851.09	258 / 258	98%	41.73	226 / 230
adipose	100%	11837.95	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	85.67	29 / 29
spleen	100%	14393.08	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	85.70	45 / 45
ureter	0%	0	0 / 0	100%	29.22	1 / 1
blood vessel	100%	11120.51	1334 / 1335	0%	0	0 / 0
muscle	100%	8250.01	802 / 803	0%	0	0 / 0
peripheral blood	99%	13504.78	921 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	99%	47.20	79 / 80
heart	98%	7202.27	847 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043484	Biological process	regulation of RNA splicing
GO_0006397	Biological process	mRNA processing
GO_0000381	Biological process	regulation of alternative mRNA splicing, via spliceosome
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0006396	Biological process	RNA processing
GO_0035770	Cellular component	ribonucleoprotein granule
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_1990904	Cellular component	ribonucleoprotein complex
GO_0000785	Cellular component	chromatin
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_0005515	Molecular function	protein binding
GO_0003729	Molecular function	mRNA binding
GO_0097157	Molecular function	pre-mRNA intronic binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	HNRNPL
Protein name	HNRNPL protein Heterogeneous nuclear ribonucleoprotein L Heterogeneous nuclear ribonucleoprotein L (hnRNP L)
Synonyms	HNRPL P/OKcl.14
Description	FUNCTION: Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements . Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts . Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter . As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation . Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. .
Accessions	B4DVF8 ENST00000601813.1 M0R1W6 ENST00000600873.5 [P14866-2] ENST00000388749.7 P14866 ENST00000601449.5 ENST00000647557.2 Q6NTA2 A0A9L9PXI4 ENST00000598985.5 A0A3B3ITJ4 ENST00000600233.5 ENST00000634237.1 [P14866-2] M0QYL7 ENST00000221419.10 [P14866-1] M0QXS5 ENST00000634753.1 [P14866-1]

HNRNPL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review