GCC2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	37 studies	27% ± 10%	Explore
B cell	33 studies	30% ± 10%	Explore
natural killer cell	33 studies	26% ± 9%	Explore
T cell	29 studies	26% ± 8%	Explore
CD4-positive, alpha-beta T cell	29 studies	31% ± 11%	Explore
fibroblast	28 studies	24% ± 9%	Explore
CD8-positive, alpha-beta T cell	26 studies	32% ± 9%	Explore
pericyte	24 studies	24% ± 7%	Explore
macrophage	23 studies	24% ± 9%	Explore
ciliated cell	20 studies	60% ± 16%	Explore
regulatory T cell	20 studies	34% ± 8%	Explore
naive B cell	19 studies	28% ± 8%	Explore
mature NK T cell	18 studies	28% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	39% ± 11%	Explore
memory B cell	17 studies	29% ± 6%	Explore
epithelial cell	16 studies	38% ± 18%	Explore
gamma-delta T cell	16 studies	35% ± 10%	Explore
smooth muscle cell	15 studies	19% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	38% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	30% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	26% ± 9%	Explore
mucosal invariant T cell	14 studies	31% ± 5%	Explore
plasmacytoid dendritic cell	13 studies	32% ± 12%	Explore
endothelial cell of lymphatic vessel	12 studies	23% ± 5%	Explore
basal cell	12 studies	27% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	34% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	37% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	38% ± 12%	Explore
glutamatergic neuron	11 studies	45% ± 25%	Explore
astrocyte	11 studies	30% ± 12%	Explore
capillary endothelial cell	10 studies	22% ± 6%	Explore
microglial cell	10 studies	30% ± 9%	Explore
oligodendrocyte	10 studies	28% ± 10%	Explore
type I pneumocyte	9 studies	27% ± 4%	Explore
secretory cell	9 studies	26% ± 8%	Explore
GABAergic neuron	9 studies	38% ± 21%	Explore
non-classical monocyte	8 studies	24% ± 11%	Explore
myofibroblast cell	8 studies	20% ± 5%	Explore
endothelial cell of artery	8 studies	18% ± 2%	Explore
goblet cell	8 studies	39% ± 19%	Explore
club cell	7 studies	28% ± 8%	Explore
neuron	7 studies	35% ± 15%	Explore
vein endothelial cell	7 studies	20% ± 7%	Explore
myeloid cell	7 studies	25% ± 8%	Explore
type II pneumocyte	7 studies	23% ± 6%	Explore
T follicular helper cell	7 studies	32% ± 10%	Explore
alveolar macrophage	6 studies	25% ± 9%	Explore
monocyte	6 studies	25% ± 6%	Explore
respiratory goblet cell	6 studies	33% ± 8%	Explore
leukocyte	6 studies	32% ± 5%	Explore
conventional dendritic cell	6 studies	25% ± 12%	Explore
progenitor cell	6 studies	23% ± 7%	Explore
abnormal cell	6 studies	31% ± 12%	Explore
retinal rod cell	6 studies	25% ± 3%	Explore
dendritic cell	6 studies	34% ± 19%	Explore
endothelial cell of vascular tree	6 studies	22% ± 6%	Explore
oligodendrocyte precursor cell	6 studies	30% ± 9%	Explore
mast cell	5 studies	25% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	27% ± 8%	Explore
enterocyte	5 studies	23% ± 6%	Explore
retinal bipolar neuron	5 studies	38% ± 15%	Explore
precursor B cell	5 studies	27% ± 9%	Explore
plasma cell	5 studies	27% ± 9%	Explore
brush cell	5 studies	32% ± 4%	Explore
amacrine cell	5 studies	31% ± 10%	Explore
mesothelial cell	5 studies	23% ± 6%	Explore
lymphocyte	5 studies	38% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	42% ± 17%	Explore
innate lymphoid cell	5 studies	29% ± 6%	Explore
adipocyte	5 studies	28% ± 8%	Explore
connective tissue cell	5 studies	24% ± 3%	Explore
interneuron	5 studies	45% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	28% ± 4%	Explore
deuterosomal cell	4 studies	29% ± 7%	Explore
classical monocyte	4 studies	26% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	30% ± 8%	Explore
glial cell	4 studies	20% ± 5%	Explore
kidney loop of Henle epithelial cell	4 studies	26% ± 5%	Explore
immature B cell	4 studies	25% ± 4%	Explore
retina horizontal cell	4 studies	22% ± 5%	Explore
retinal cone cell	4 studies	36% ± 9%	Explore
Mueller cell	4 studies	22% ± 5%	Explore
hepatocyte	4 studies	34% ± 17%	Explore
enteroendocrine cell	4 studies	33% ± 12%	Explore
mucus secreting cell	4 studies	26% ± 6%	Explore
double negative thymocyte	4 studies	42% ± 9%	Explore
erythrocyte	4 studies	33% ± 14%	Explore
ionocyte	3 studies	30% ± 8%	Explore
squamous epithelial cell	3 studies	43% ± 22%	Explore
exhausted T cell	3 studies	38% ± 14%	Explore
plasmablast	3 studies	37% ± 13%	Explore
glomerular endothelial cell	3 studies	27% ± 7%	Explore
renal alpha-intercalated cell	3 studies	21% ± 1%	Explore
intestinal crypt stem cell	3 studies	20% ± 4%	Explore
GABAergic interneuron	3 studies	23% ± 4%	Explore
retinal ganglion cell	3 studies	51% ± 16%	Explore
ON-bipolar cell	3 studies	33% ± 11%	Explore
rod bipolar cell	3 studies	59% ± 7%	Explore
CD4-positive helper T cell	3 studies	39% ± 9%	Explore
granulocyte	3 studies	24% ± 4%	Explore
adventitial cell	3 studies	18% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	34% ± 8%	Explore
transit amplifying cell	3 studies	31% ± 21%	Explore
T-helper 17 cell	3 studies	29% ± 5%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	41% ± 4%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	39% ± 11%	Explore
epithelial cell of proximal tubule	3 studies	18% ± 3%	Explore
mural cell	3 studies	34% ± 13%	Explore
renal principal cell	3 studies	30% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	32% ± 19%	Explore
lung	17 studies	26% ± 8%	Explore
peripheral blood	16 studies	30% ± 9%	Explore
intestine	9 studies	22% ± 7%	Explore
eye	9 studies	28% ± 10%	Explore
kidney	6 studies	23% ± 3%	Explore
liver	5 studies	32% ± 12%	Explore
bone marrow	4 studies	21% ± 4%	Explore
breast	4 studies	18% ± 2%	Explore
adipose	4 studies	25% ± 3%	Explore
uterus	3 studies	36% ± 16%	Explore
lymph node	3 studies	31% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2279.25	1445 / 1445	100%	21.62	183 / 183
prostate	100%	3660.89	245 / 245	100%	25.41	501 / 502
lung	100%	3157.31	578 / 578	99%	13.07	1141 / 1155
brain	100%	2499.96	2635 / 2642	99%	10.07	696 / 705
stomach	100%	2504.17	359 / 359	98%	17.77	279 / 286
breast	100%	3269.96	459 / 459	97%	15.47	1089 / 1118
thymus	100%	3372.71	653 / 653	97%	13.93	589 / 605
ovary	100%	3484.76	180 / 180	97%	8.11	416 / 430
intestine	100%	3423.22	966 / 966	97%	15.84	509 / 527
pancreas	99%	1837.31	326 / 328	97%	16.26	173 / 178
kidney	100%	2664.36	89 / 89	95%	14.40	853 / 901
bladder	100%	3023.52	21 / 21	94%	9.50	472 / 504
uterus	100%	2776.70	170 / 170	92%	7.91	420 / 459
adrenal gland	100%	2871.05	258 / 258	90%	9.66	206 / 230
skin	100%	2484.65	1808 / 1809	82%	9.06	385 / 472
liver	100%	1285.93	226 / 226	64%	4.93	259 / 406
adipose	100%	2690.08	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2658.09	1335 / 1335	0%	0	0 / 0
spleen	100%	2932.14	241 / 241	0%	0	0 / 0
muscle	100%	1578.20	799 / 803	0%	0	0 / 0
heart	96%	1361.77	830 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	82%	5.78	37 / 45
lymph node	0%	0	0 / 0	79%	8.49	23 / 29
peripheral blood	77%	1597.29	719 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	57%	4.77	46 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0042147	Biological process	retrograde transport, endosome to Golgi
GO_0071955	Biological process	recycling endosome to Golgi transport
GO_0043001	Biological process	Golgi to plasma membrane protein transport
GO_0034453	Biological process	microtubule anchoring
GO_0031023	Biological process	microtubule organizing center organization
GO_0006622	Biological process	protein targeting to lysosome
GO_0034499	Biological process	late endosome to Golgi transport
GO_0090161	Biological process	Golgi ribbon formation
GO_0034067	Biological process	protein localization to Golgi apparatus
GO_0070861	Biological process	regulation of protein exit from endoplasmic reticulum
GO_0005802	Cellular component	trans-Golgi network
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005794	Cellular component	Golgi apparatus
GO_0016020	Cellular component	membrane
GO_0005515	Molecular function	protein binding
GO_0042802	Molecular function	identical protein binding
GO_0031267	Molecular function	small GTPase binding

IV. Literature review

[source]

Gene name	GCC2
Protein name	GRIP and coiled-coil domain containing 2 GCC2 protein GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) (CLL-associated antigen KW-11) (CTCL tumor antigen se1-1) (Ran-binding protein 2-like 4) (RanBP2L4) (Renal carcinoma antigen NY-REN-53)
Synonyms	KIAA0336 RANBP2L4
Description	FUNCTION: Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. .
Accessions	ENST00000409896.1 U3KQE0 ENST00000492785.1 ENST00000687399.1 A0A8I5KW38 ENST00000482325.5 [Q8IWJ2-3] A0A8I5QJB7 B8ZZW2 ENST00000692694.1 A0A8I5KVA2 ENST00000685519.1 A0PJA5 H7BYJ9 B8ZZA5 ENST00000309863.11 [Q8IWJ2-1] U3KPU4 Q8IWJ2 ENST00000393321.2 ENST00000462897.2 ENST00000409821.5

GCC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review