Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 22 studies | 43% ± 14% | |
mast cell | 20 studies | 53% ± 22% | |
astrocyte | 19 studies | 50% ± 19% | |
oligodendrocyte | 15 studies | 39% ± 13% | |
oligodendrocyte precursor cell | 15 studies | 52% ± 18% | |
microglial cell | 15 studies | 56% ± 14% | |
glutamatergic neuron | 13 studies | 59% ± 23% | |
macrophage | 12 studies | 43% ± 20% | |
fibroblast | 12 studies | 46% ± 13% | |
GABAergic neuron | 11 studies | 62% ± 21% | |
pericyte | 10 studies | 43% ± 13% | |
smooth muscle cell | 10 studies | 37% ± 11% | |
adipocyte | 9 studies | 38% ± 12% | |
endothelial cell of lymphatic vessel | 8 studies | 43% ± 14% | |
epithelial cell | 7 studies | 40% ± 19% | |
interneuron | 7 studies | 65% ± 24% | |
mesothelial cell | 7 studies | 45% ± 15% | |
neuron | 6 studies | 53% ± 19% | |
ciliated cell | 6 studies | 33% ± 17% | |
myeloid cell | 6 studies | 31% ± 8% | |
cardiac muscle cell | 5 studies | 27% ± 6% | |
monocyte | 5 studies | 30% ± 8% | |
type I pneumocyte | 5 studies | 49% ± 8% | |
type II pneumocyte | 5 studies | 36% ± 7% | |
granule cell | 4 studies | 48% ± 11% | |
dendritic cell | 4 studies | 27% ± 6% | |
vein endothelial cell | 4 studies | 30% ± 14% | |
Mueller cell | 4 studies | 43% ± 19% | |
amacrine cell | 4 studies | 52% ± 18% | |
retina horizontal cell | 4 studies | 46% ± 20% | |
retinal cone cell | 4 studies | 38% ± 17% | |
retinal ganglion cell | 4 studies | 61% ± 25% | |
retinal rod cell | 4 studies | 39% ± 12% | |
club cell | 4 studies | 33% ± 9% | |
hepatic stellate cell | 3 studies | 43% ± 16% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 53% ± 5% | |
GABAergic interneuron | 3 studies | 70% ± 2% | |
progenitor cell | 3 studies | 45% ± 0% | |
plasma cell | 3 studies | 23% ± 6% | |
GABAergic amacrine cell | 3 studies | 61% ± 15% | |
glycinergic amacrine cell | 3 studies | 47% ± 10% | |
endothelial cell of vascular tree | 3 studies | 38% ± 13% | |
hepatocyte | 3 studies | 36% ± 19% | |
retinal pigment epithelial cell | 3 studies | 53% ± 23% | |
neural progenitor cell | 3 studies | 44% ± 15% | |
connective tissue cell | 3 studies | 32% ± 11% | |
ependymal cell | 3 studies | 63% ± 13% | |
B cell | 3 studies | 24% ± 9% | |
alveolar macrophage | 3 studies | 39% ± 8% | |
capillary endothelial cell | 3 studies | 34% ± 4% | |
basal cell | 3 studies | 51% ± 28% | |
mucus secreting cell | 3 studies | 26% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 1271.69 | 2638 / 2642 | 99% | 9.72 | 700 / 705 |
thymus | 100% | 2385.21 | 653 / 653 | 93% | 7.12 | 560 / 605 |
adrenal gland | 100% | 1486.66 | 258 / 258 | 92% | 6.07 | 212 / 230 |
esophagus | 100% | 1932.44 | 1445 / 1445 | 90% | 5.71 | 165 / 183 |
kidney | 100% | 1083.13 | 89 / 89 | 90% | 5.94 | 808 / 901 |
skin | 100% | 2046.83 | 1809 / 1809 | 89% | 7.51 | 418 / 472 |
breast | 100% | 1801.31 | 459 / 459 | 89% | 5.20 | 990 / 1118 |
lung | 100% | 1777.89 | 578 / 578 | 87% | 4.32 | 1001 / 1155 |
pancreas | 93% | 556.09 | 304 / 328 | 92% | 4.76 | 164 / 178 |
uterus | 100% | 2167.89 | 170 / 170 | 84% | 4.48 | 387 / 459 |
prostate | 100% | 1501.07 | 244 / 245 | 81% | 3.53 | 407 / 502 |
stomach | 99% | 1131.86 | 355 / 359 | 69% | 3.26 | 198 / 286 |
bladder | 100% | 1946.10 | 21 / 21 | 66% | 2.94 | 335 / 504 |
intestine | 100% | 1838.96 | 966 / 966 | 61% | 2.52 | 319 / 527 |
ovary | 100% | 1675.31 | 180 / 180 | 60% | 2.23 | 259 / 430 |
liver | 67% | 285.44 | 151 / 226 | 34% | 1.40 | 138 / 406 |
blood vessel | 100% | 2203.09 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 1102.55 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 2060.94 | 1203 / 1204 | 0% | 0 | 0 / 0 |
heart | 97% | 902.81 | 837 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 87% | 5.57 | 39 / 45 |
eye | 0% | 0 | 0 / 0 | 66% | 3.33 | 53 / 80 |
muscle | 64% | 299.92 | 517 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 45% | 1.40 | 13 / 29 |
peripheral blood | 21% | 346.13 | 195 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0019221 | Biological process | cytokine-mediated signaling pathway |
GO_0030838 | Biological process | positive regulation of actin filament polymerization |
GO_0038109 | Biological process | Kit signaling pathway |
GO_0007260 | Biological process | tyrosine phosphorylation of STAT protein |
GO_0034614 | Biological process | cellular response to reactive oxygen species |
GO_0034333 | Biological process | adherens junction assembly |
GO_0120179 | Biological process | adherens junction disassembly |
GO_0060009 | Biological process | Sertoli cell development |
GO_0033007 | Biological process | negative regulation of mast cell activation involved in immune response |
GO_0038095 | Biological process | Fc-epsilon receptor signaling pathway |
GO_0006935 | Biological process | chemotaxis |
GO_0001932 | Biological process | regulation of protein phosphorylation |
GO_0007155 | Biological process | cell adhesion |
GO_0050904 | Biological process | diapedesis |
GO_0072520 | Biological process | seminiferous tubule development |
GO_0036006 | Biological process | cellular response to macrophage colony-stimulating factor stimulus |
GO_0044331 | Biological process | cell-cell adhesion mediated by cadherin |
GO_0042058 | Biological process | regulation of epidermal growth factor receptor signaling pathway |
GO_0048008 | Biological process | platelet-derived growth factor receptor signaling pathway |
GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_0018108 | Biological process | peptidyl-tyrosine phosphorylation |
GO_0070102 | Biological process | interleukin-6-mediated signaling pathway |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0008286 | Biological process | insulin receptor signaling pathway |
GO_0034446 | Biological process | substrate adhesion-dependent cell spreading |
GO_0030335 | Biological process | positive regulation of cell migration |
GO_0007281 | Biological process | germ cell development |
GO_0000226 | Biological process | microtubule cytoskeleton organization |
GO_0036119 | Biological process | response to platelet-derived growth factor |
GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0010762 | Biological process | regulation of fibroblast migration |
GO_0006468 | Biological process | protein phosphorylation |
GO_0035426 | Biological process | extracellular matrix-cell signaling |
GO_0046777 | Biological process | protein autophosphorylation |
GO_0032496 | Biological process | response to lipopolysaccharide |
GO_0010591 | Biological process | regulation of lamellipodium assembly |
GO_0005886 | Cellular component | plasma membrane |
GO_0009898 | Cellular component | cytoplasmic side of plasma membrane |
GO_0015629 | Cellular component | actin cytoskeleton |
GO_0005829 | Cellular component | cytosol |
GO_0005912 | Cellular component | adherens junction |
GO_0005938 | Cellular component | cell cortex |
GO_0015630 | Cellular component | microtubule cytoskeleton |
GO_0005737 | Cellular component | cytoplasm |
GO_0030054 | Cellular component | cell junction |
GO_0030027 | Cellular component | lamellipodium |
GO_0000785 | Cellular component | chromatin |
GO_0005634 | Cellular component | nucleus |
GO_0004715 | Molecular function | non-membrane spanning protein tyrosine kinase activity |
GO_0008289 | Molecular function | lipid binding |
GO_0004713 | Molecular function | protein tyrosine kinase activity |
GO_0005154 | Molecular function | epidermal growth factor receptor binding |
GO_0008157 | Molecular function | protein phosphatase 1 binding |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | FER |
Protein name | FER tyrosine kinase Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer) FER protein Tyrosine-protein kinase (EC 2.7.10.2) |
Synonyms | Pe1Fe10 TYK3 |
Description | FUNCTION: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. . |
Accessions | ENST00000438717.6 Q6PEJ9 D6RAF9 ENST00000281092.9 [P16591-1] Q05DA5 P16591 ENST00000504143.6 ENST00000618353.1 [P16591-3] W0S4B9 |