FER report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019221Biological processcytokine-mediated signaling pathway
GO_0030838Biological processpositive regulation of actin filament polymerization
GO_0038109Biological processKit signaling pathway
GO_0007260Biological processtyrosine phosphorylation of STAT protein
GO_0034614Biological processcellular response to reactive oxygen species
GO_0034333Biological processadherens junction assembly
GO_0120179Biological processadherens junction disassembly
GO_0060009Biological processSertoli cell development
GO_0033007Biological processnegative regulation of mast cell activation involved in immune response
GO_0038095Biological processFc-epsilon receptor signaling pathway
GO_0006935Biological processchemotaxis
GO_0001932Biological processregulation of protein phosphorylation
GO_0007155Biological processcell adhesion
GO_0050904Biological processdiapedesis
GO_0072520Biological processseminiferous tubule development
GO_0036006Biological processcellular response to macrophage colony-stimulating factor stimulus
GO_0044331Biological processcell-cell adhesion mediated by cadherin
GO_0042058Biological processregulation of epidermal growth factor receptor signaling pathway
GO_0048008Biological processplatelet-derived growth factor receptor signaling pathway
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0030036Biological processactin cytoskeleton organization
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0070102Biological processinterleukin-6-mediated signaling pathway
GO_0035556Biological processintracellular signal transduction
GO_0008286Biological processinsulin receptor signaling pathway
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_0030335Biological processpositive regulation of cell migration
GO_0007281Biological processgerm cell development
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0036119Biological processresponse to platelet-derived growth factor
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0010762Biological processregulation of fibroblast migration
GO_0006468Biological processprotein phosphorylation
GO_0035426Biological processextracellular matrix-cell signaling
GO_0046777Biological processprotein autophosphorylation
GO_0032496Biological processresponse to lipopolysaccharide
GO_0010591Biological processregulation of lamellipodium assembly
GO_0005886Cellular componentplasma membrane
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0005938Cellular componentcell cortex
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0030054Cellular componentcell junction
GO_0030027Cellular componentlamellipodium
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0008289Molecular functionlipid binding
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0005154Molecular functionepidermal growth factor receptor binding
GO_0008157Molecular functionprotein phosphatase 1 binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFER
Protein nameFER tyrosine kinase
Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer)
FER protein
Tyrosine-protein kinase (EC 2.7.10.2)
SynonymsPe1Fe10
TYK3
DescriptionFUNCTION: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. .

AccessionsENST00000438717.6
Q6PEJ9
D6RAF9
ENST00000281092.9 [P16591-1]
Q05DA5
P16591
ENST00000504143.6
ENST00000618353.1 [P16591-3]
W0S4B9