EML4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
T cell	34 studies	37% ± 15%	Explore
CD8-positive, alpha-beta T cell	34 studies	34% ± 10%	Explore
B cell	33 studies	34% ± 11%	Explore
CD4-positive, alpha-beta T cell	33 studies	38% ± 13%	Explore
natural killer cell	29 studies	30% ± 9%	Explore
regulatory T cell	28 studies	42% ± 11%	Explore
macrophage	27 studies	32% ± 12%	Explore
endothelial cell	23 studies	32% ± 15%	Explore
fibroblast	22 studies	27% ± 12%	Explore
memory B cell	20 studies	35% ± 9%	Explore
naive B cell	19 studies	30% ± 10%	Explore
mature NK T cell	19 studies	32% ± 13%	Explore
gamma-delta T cell	16 studies	39% ± 13%	Explore
mucosal invariant T cell	16 studies	52% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	34% ± 12%	Explore
non-classical monocyte	16 studies	28% ± 10%	Explore
pericyte	16 studies	25% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	39% ± 13%	Explore
microglial cell	15 studies	45% ± 17%	Explore
monocyte	14 studies	36% ± 18%	Explore
epithelial cell	14 studies	35% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	25% ± 9%	Explore
myeloid cell	13 studies	32% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	43% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	47% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	47% ± 13%	Explore
basal cell	12 studies	36% ± 14%	Explore
smooth muscle cell	12 studies	23% ± 8%	Explore
endothelial cell of lymphatic vessel	11 studies	29% ± 11%	Explore
plasmacytoid dendritic cell	11 studies	26% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	33% ± 10%	Explore
type II pneumocyte	9 studies	37% ± 12%	Explore
leukocyte	9 studies	44% ± 19%	Explore
connective tissue cell	9 studies	28% ± 14%	Explore
oligodendrocyte precursor cell	9 studies	28% ± 11%	Explore
adipocyte	9 studies	36% ± 16%	Explore
astrocyte	9 studies	30% ± 15%	Explore
alveolar macrophage	8 studies	59% ± 17%	Explore
dendritic cell	8 studies	28% ± 10%	Explore
innate lymphoid cell	8 studies	35% ± 11%	Explore
club cell	8 studies	30% ± 9%	Explore
classical monocyte	8 studies	22% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	32% ± 6%	Explore
myofibroblast cell	7 studies	26% ± 13%	Explore
goblet cell	7 studies	31% ± 22%	Explore
T follicular helper cell	7 studies	43% ± 9%	Explore
CD4-positive helper T cell	6 studies	45% ± 20%	Explore
respiratory goblet cell	6 studies	38% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	38% ± 7%	Explore
conventional dendritic cell	6 studies	22% ± 4%	Explore
glutamatergic neuron	6 studies	46% ± 24%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	48% ± 13%	Explore
GABAergic neuron	6 studies	41% ± 19%	Explore
mast cell	5 studies	26% ± 9%	Explore
exhausted T cell	5 studies	32% ± 9%	Explore
abnormal cell	5 studies	33% ± 24%	Explore
enteroendocrine cell	5 studies	30% ± 6%	Explore
transit amplifying cell	5 studies	33% ± 19%	Explore
interneuron	5 studies	36% ± 21%	Explore
lymphocyte	5 studies	53% ± 25%	Explore
type I pneumocyte	5 studies	25% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	36% ± 9%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	25% ± 8%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	29% ± 7%	Explore
secretory cell	4 studies	34% ± 11%	Explore
plasmablast	4 studies	27% ± 8%	Explore
progenitor cell	4 studies	25% ± 4%	Explore
enterocyte	4 studies	19% ± 4%	Explore
intestinal crypt stem cell	4 studies	26% ± 5%	Explore
precursor B cell	4 studies	28% ± 9%	Explore
plasma cell	4 studies	26% ± 4%	Explore
immature B cell	4 studies	30% ± 4%	Explore
mesothelial cell	4 studies	22% ± 7%	Explore
ciliated cell	4 studies	34% ± 8%	Explore
Mueller cell	4 studies	39% ± 9%	Explore
amacrine cell	4 studies	21% ± 6%	Explore
retinal rod cell	4 studies	29% ± 14%	Explore
hepatocyte	4 studies	61% ± 20%	Explore
group 3 innate lymphoid cell	4 studies	60% ± 8%	Explore
T-helper 17 cell	4 studies	40% ± 16%	Explore
neuron	4 studies	49% ± 25%	Explore
oligodendrocyte	4 studies	25% ± 12%	Explore
T-helper 1 cell	4 studies	46% ± 11%	Explore
epithelial cell of proximal tubule	3 studies	20% ± 3%	Explore
podocyte	3 studies	43% ± 19%	Explore
renal alpha-intercalated cell	3 studies	27% ± 8%	Explore
interstitial cell of Cajal	3 studies	32% ± 14%	Explore
glial cell	3 studies	20% ± 2%	Explore
placental villous trophoblast	3 studies	33% ± 9%	Explore
vein endothelial cell	3 studies	34% ± 22%	Explore
glycinergic amacrine cell	3 studies	16% ± 0%	Explore
intermediate monocyte	3 studies	34% ± 19%	Explore
endothelial cell of vascular tree	3 studies	33% ± 18%	Explore
cholangiocyte	3 studies	56% ± 11%	Explore
brush cell	3 studies	20% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	36% ± 5%	Explore
double negative thymocyte	3 studies	40% ± 22%	Explore
double-positive, alpha-beta thymocyte	3 studies	42% ± 20%	Explore
mural cell	3 studies	44% ± 24%	Explore
mucus secreting cell	3 studies	33% ± 7%	Explore
erythrocyte	3 studies	22% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	29% ± 10%	Explore
peripheral blood	17 studies	28% ± 10%	Explore
brain	11 studies	32% ± 17%	Explore
intestine	9 studies	21% ± 5%	Explore
kidney	5 studies	23% ± 4%	Explore
eye	5 studies	33% ± 16%	Explore
liver	5 studies	36% ± 22%	Explore
lymph node	4 studies	27% ± 10%	Explore
adipose	4 studies	25% ± 3%	Explore
bone marrow	3 studies	30% ± 12%	Explore
uterus	3 studies	22% ± 8%	Explore
placenta	3 studies	29% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	100%	4877.05	966 / 966	100%	48.32	527 / 527
esophagus	100%	2612.09	1443 / 1445	100%	54.71	183 / 183
lung	100%	8498.39	578 / 578	100%	52.20	1153 / 1155
ovary	100%	3646.93	180 / 180	100%	31.30	429 / 430
stomach	100%	3667.77	359 / 359	100%	47.96	285 / 286
uterus	100%	3178.11	170 / 170	100%	42.34	457 / 459
liver	100%	4453.32	226 / 226	100%	36.67	404 / 406
thymus	100%	5110.78	653 / 653	100%	35.54	602 / 605
bladder	100%	3739.95	21 / 21	99%	37.08	501 / 504
breast	100%	3851.61	459 / 459	99%	31.15	1109 / 1118
pancreas	100%	4086.05	328 / 328	99%	38.78	176 / 178
prostate	100%	3491.99	245 / 245	99%	25.52	495 / 502
kidney	100%	4148.26	89 / 89	97%	34.03	871 / 901
skin	100%	6054.28	1809 / 1809	96%	25.82	451 / 472
adrenal gland	100%	5303.57	258 / 258	87%	23.29	200 / 230
brain	86%	1204.26	2259 / 2642	92%	14.65	649 / 705
adipose	100%	3769.57	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	33.64	29 / 29
spleen	100%	9306.76	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	37.22	45 / 45
ureter	0%	0	0 / 0	100%	16.30	1 / 1
blood vessel	100%	3582.76	1330 / 1335	0%	0	0 / 0
peripheral blood	94%	3718.18	874 / 929	0%	0	0 / 0
heart	75%	1114.83	649 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	74%	10.23	59 / 80
muscle	25%	253.45	201 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0008608	Biological process	attachment of spindle microtubules to kinetochore
GO_0000278	Biological process	mitotic cell cycle
GO_0007017	Biological process	microtubule-based process
GO_0051301	Biological process	cell division
GO_0000226	Biological process	microtubule cytoskeleton organization
GO_0007080	Biological process	mitotic metaphase chromosome alignment
GO_0030496	Cellular component	midbody
GO_0005874	Cellular component	microtubule
GO_0072686	Cellular component	mitotic spindle
GO_0016020	Cellular component	membrane
GO_0005815	Cellular component	microtubule organizing center
GO_0005829	Cellular component	cytosol
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0005737	Cellular component	cytoplasm
GO_0048487	Molecular function	beta-tubulin binding
GO_0043014	Molecular function	alpha-tubulin binding
GO_0008017	Molecular function	microtubule binding
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

IV. Literature review

[source]

Gene name	EML4
Protein name	Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) Uncharacterized protein EML4 EMAP like 4
Synonyms	C2orf2 EMAPL4
Description	FUNCTION: Essential for the formation and stability of microtubules (MTs) . Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs . Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression . .
Accessions	ENST00000401738.3 B5MBZ0 ENST00000402711.6 [Q9HC35-2] Q9HC35 ENST00000318522.10 [Q9HC35-1] Q583U9

EML4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review