ELOVL5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030148Biological processsphingolipid biosynthetic process
GO_0042761Biological processvery long-chain fatty acid biosynthetic process
GO_0034626Biological processfatty acid elongation, polyunsaturated fatty acid
GO_0036109Biological processalpha-linolenic acid metabolic process
GO_0019367Biological processfatty acid elongation, saturated fatty acid
GO_0043651Biological processlinoleic acid metabolic process
GO_0034625Biological processfatty acid elongation, monounsaturated fatty acid
GO_0035338Biological processlong-chain fatty-acyl-CoA biosynthetic process
GO_0006636Biological processunsaturated fatty acid biosynthetic process
GO_0045723Biological processpositive regulation of fatty acid biosynthetic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0097447Cellular componentdendritic tree
GO_0005783Cellular componentendoplasmic reticulum
GO_0043025Cellular componentneuronal cell body
GO_0016020Cellular componentmembrane
GO_0030425Cellular componentdendrite
GO_0005515Molecular functionprotein binding
GO_0009922Molecular functionfatty acid elongase activity

IV. Literature review

[source]
Gene nameELOVL5
Protein nameVery long chain fatty acid elongase 5 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL5) (ELOVL fatty acid elongase 5) (ELOVL FA elongase 5) (Elongation of very long chain fatty acids protein 5) (Fatty acid elongase 1) (hELO1) (Very long chain 3-ketoacyl-CoA synthase 5) (Very long chain 3-oxoacyl-CoA synthase 5)
Elongation of very long chain fatty acids protein 5 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL5) (ELOVL fatty acid elongase 5) (ELOVL FA elongase 5) (Very long chain 3-ketoacyl-CoA synthase 5) (Very long chain 3-oxoacyl-CoA synthase 5)
Elongation of very long chain fatty acids protein (EC 2.3.1.199) (Very-long-chain 3-oxoacyl-CoA synthase)
SynonymsELOVL2
hCG_2001424
PRO0530
DescriptionFUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. .

FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity) . In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (By similarity). .

AccessionsB3KWH9
ENST00000542638.5
ENST00000370918.8 [Q9NYP7-2]
ENST00000370913.5 [Q9NYP7-3]
Q9NYP7
ENST00000304434.11 [Q9NYP7-1]
A0A0A0MTI6