DYNC1H1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	38 studies	33% ± 15%	Explore
macrophage	30 studies	29% ± 12%	Explore
fibroblast	29 studies	26% ± 8%	Explore
natural killer cell	27 studies	24% ± 8%	Explore
pericyte	27 studies	27% ± 12%	Explore
CD8-positive, alpha-beta T cell	23 studies	24% ± 8%	Explore
smooth muscle cell	21 studies	24% ± 5%	Explore
T cell	20 studies	23% ± 9%	Explore
classical monocyte	20 studies	26% ± 12%	Explore
CD4-positive, alpha-beta T cell	19 studies	21% ± 5%	Explore
astrocyte	18 studies	32% ± 14%	Explore
endothelial cell of lymphatic vessel	17 studies	34% ± 13%	Explore
regulatory T cell	17 studies	21% ± 4%	Explore
conventional dendritic cell	16 studies	26% ± 13%	Explore
non-classical monocyte	16 studies	26% ± 13%	Explore
ciliated cell	15 studies	36% ± 12%	Explore
epithelial cell	15 studies	33% ± 17%	Explore
oligodendrocyte	15 studies	35% ± 12%	Explore
capillary endothelial cell	15 studies	26% ± 8%	Explore
gamma-delta T cell	15 studies	28% ± 8%	Explore
dendritic cell	14 studies	34% ± 21%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	27% ± 8%	Explore
monocyte	13 studies	24% ± 5%	Explore
plasmacytoid dendritic cell	13 studies	26% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	27% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	26% ± 7%	Explore
oligodendrocyte precursor cell	13 studies	32% ± 12%	Explore
mast cell	12 studies	24% ± 9%	Explore
type I pneumocyte	12 studies	33% ± 9%	Explore
glutamatergic neuron	12 studies	55% ± 19%	Explore
mucosal invariant T cell	12 studies	23% ± 5%	Explore
B cell	11 studies	23% ± 8%	Explore
basal cell	11 studies	33% ± 12%	Explore
endothelial cell of artery	11 studies	28% ± 11%	Explore
vein endothelial cell	11 studies	27% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	22% ± 3%	Explore
GABAergic neuron	10 studies	50% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	28% ± 9%	Explore
mature NK T cell	10 studies	25% ± 3%	Explore
connective tissue cell	10 studies	26% ± 7%	Explore
neuron	10 studies	53% ± 12%	Explore
microglial cell	10 studies	30% ± 13%	Explore
myeloid cell	10 studies	31% ± 10%	Explore
memory B cell	9 studies	17% ± 1%	Explore
myofibroblast cell	9 studies	26% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	22% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	21% ± 5%	Explore
adipocyte	8 studies	24% ± 6%	Explore
club cell	7 studies	29% ± 11%	Explore
respiratory goblet cell	7 studies	29% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	22% ± 4%	Explore
naive B cell	7 studies	19% ± 1%	Explore
abnormal cell	7 studies	28% ± 10%	Explore
amacrine cell	7 studies	33% ± 8%	Explore
interneuron	7 studies	54% ± 19%	Explore
retinal ganglion cell	7 studies	76% ± 23%	Explore
endothelial cell of vascular tree	7 studies	26% ± 11%	Explore
goblet cell	7 studies	29% ± 14%	Explore
type II pneumocyte	6 studies	21% ± 6%	Explore
leukocyte	6 studies	24% ± 3%	Explore
lymphocyte	6 studies	35% ± 9%	Explore
innate lymphoid cell	6 studies	24% ± 7%	Explore
retina horizontal cell	6 studies	38% ± 10%	Explore
retinal rod cell	6 studies	26% ± 7%	Explore
secretory cell	5 studies	37% ± 12%	Explore
brush cell	5 studies	36% ± 15%	Explore
retinal cone cell	5 studies	29% ± 7%	Explore
cardiac muscle cell	5 studies	20% ± 3%	Explore
T follicular helper cell	5 studies	20% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	28% ± 11%	Explore
alveolar macrophage	5 studies	29% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	20% ± 3%	Explore
hematopoietic precursor cell	4 studies	29% ± 16%	Explore
plasmablast	4 studies	35% ± 16%	Explore
pancreatic A cell	4 studies	46% ± 23%	Explore
exhausted T cell	4 studies	26% ± 9%	Explore
retinal bipolar neuron	4 studies	24% ± 5%	Explore
glial cell	4 studies	29% ± 7%	Explore
granule cell	4 studies	43% ± 6%	Explore
progenitor cell	4 studies	31% ± 8%	Explore
hematopoietic stem cell	4 studies	21% ± 2%	Explore
mesothelial cell	4 studies	23% ± 6%	Explore
mononuclear phagocyte	4 studies	26% ± 8%	Explore
enteroendocrine cell	4 studies	28% ± 6%	Explore
transit amplifying cell	4 studies	28% ± 18%	Explore
ionocyte	3 studies	53% ± 6%	Explore
pancreatic D cell	3 studies	44% ± 31%	Explore
type B pancreatic cell	3 studies	53% ± 32%	Explore
glomerular endothelial cell	3 studies	28% ± 7%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	37% ± 12%	Explore
GABAergic interneuron	3 studies	49% ± 11%	Explore
precursor B cell	3 studies	25% ± 6%	Explore
pro-B cell	3 studies	23% ± 3%	Explore
retinal pigment epithelial cell	3 studies	32% ± 11%	Explore
Mueller cell	3 studies	21% ± 4%	Explore
OFF-bipolar cell	3 studies	52% ± 32%	Explore
ON-bipolar cell	3 studies	54% ± 31%	Explore
rod bipolar cell	3 studies	33% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	20% ± 4%	Explore
CD4-positive helper T cell	3 studies	27% ± 8%	Explore
muscle cell	3 studies	29% ± 7%	Explore
pancreatic ductal cell	3 studies	55% ± 28%	Explore
adventitial cell	3 studies	22% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	30% ± 7%	Explore
T-helper 17 cell	3 studies	19% ± 2%	Explore
double negative thymocyte	3 studies	33% ± 10%	Explore
mural cell	3 studies	40% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	45% ± 18%	Explore
lung	14 studies	27% ± 10%	Explore
peripheral blood	14 studies	26% ± 12%	Explore
eye	10 studies	27% ± 10%	Explore
kidney	5 studies	22% ± 3%	Explore
heart	5 studies	21% ± 5%	Explore
intestine	5 studies	21% ± 6%	Explore
adipose	4 studies	31% ± 7%	Explore
pancreas	3 studies	51% ± 26%	Explore
uterus	3 studies	31% ± 10%	Explore
lymph node	3 studies	17% ± 0%	Explore
breast	3 studies	23% ± 5%	Explore
liver	3 studies	27% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	20961.06	1445 / 1445	100%	55.90	183 / 183
skin	100%	29956.34	1808 / 1809	100%	49.28	471 / 472
breast	100%	16895.34	459 / 459	100%	41.73	1113 / 1118
brain	100%	29192.16	2640 / 2642	100%	53.97	702 / 705
prostate	100%	14306.40	245 / 245	99%	34.36	499 / 502
thymus	100%	16876.11	653 / 653	99%	30.14	601 / 605
bladder	100%	20273.90	21 / 21	99%	28.55	500 / 504
intestine	100%	21203.51	966 / 966	99%	29.78	522 / 527
uterus	100%	19172.80	170 / 170	98%	27.36	452 / 459
stomach	99%	14304.16	357 / 359	99%	31.84	283 / 286
lung	100%	18408.08	577 / 578	98%	32.94	1134 / 1155
kidney	100%	10920.40	89 / 89	96%	25.33	865 / 901
adrenal gland	100%	16968.48	257 / 258	95%	37.90	218 / 230
pancreas	93%	7973.55	306 / 328	98%	30.41	175 / 178
ovary	100%	17428.08	180 / 180	91%	17.29	393 / 430
liver	57%	3805.81	129 / 226	70%	11.04	286 / 406
adipose	100%	18350.86	1204 / 1204	0%	0	0 / 0
blood vessel	100%	21812.91	1335 / 1335	0%	0	0 / 0
muscle	100%	25281.00	803 / 803	0%	0	0 / 0
spleen	100%	13439.25	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	32.08	45 / 45
ureter	0%	0	0 / 0	100%	13.51	1 / 1
eye	0%	0	0 / 0	98%	32.20	78 / 80
heart	96%	16349.11	826 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	18.03	27 / 29
peripheral blood	48%	4966.04	446 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0034063	Biological process	stress granule assembly
GO_0031122	Biological process	cytoplasmic microtubule organization
GO_0008090	Biological process	retrograde axonal transport
GO_0007052	Biological process	mitotic spindle organization
GO_0051301	Biological process	cell division
GO_0033962	Biological process	P-body assembly
GO_1905832	Biological process	positive regulation of spindle assembly
GO_0051293	Biological process	establishment of spindle localization
GO_0120162	Biological process	positive regulation of cold-induced thermogenesis
GO_0007097	Biological process	nuclear migration
GO_0060236	Biological process	regulation of mitotic spindle organization
GO_0090235	Biological process	regulation of metaphase plate congression
GO_0032388	Biological process	positive regulation of intracellular transport
GO_0035578	Cellular component	azurophil granule lumen
GO_0005576	Cellular component	extracellular region
GO_0005874	Cellular component	microtubule
GO_0016020	Cellular component	membrane
GO_0005813	Cellular component	centrosome
GO_0070062	Cellular component	extracellular exosome
GO_0005868	Cellular component	cytoplasmic dynein complex
GO_0030175	Cellular component	filopodium
GO_0005829	Cellular component	cytosol
GO_0005938	Cellular component	cell cortex
GO_0005881	Cellular component	cytoplasmic microtubule
GO_0030286	Cellular component	dynein complex
GO_1904115	Cellular component	axon cytoplasm
GO_0005524	Molecular function	ATP binding
GO_0003723	Molecular function	RNA binding
GO_0051959	Molecular function	dynein light intermediate chain binding
GO_0008569	Molecular function	minus-end-directed microtubule motor activity
GO_0045505	Molecular function	dynein intermediate chain binding
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	DYNC1H1
Protein name	DYNC1H1 protein Dynein cytoplasmic 1 heavy chain 1 Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)
Synonyms	DNECL DHC1 DYHC KIAA0325 DNCL DNCH1
Description	FUNCTION: Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression . .
Accessions	ENST00000681311.1 A0A7P0T916 ENST00000679910.1 A0A2R8Y706 A0A804HHY6 ENST00000681283.1 A0A2R8Y5T0 ENST00000681536.1 A0A7P0T825 A0A7P0T9F1 A0A7P0TB64 A0A7P0T8N2 A0A7P0T9C4 A0A2R8Y6H2 A0A7P0T9R4 ENST00000681123.1 A0A7P0TAV5 ENST00000681859.1 ENST00000680120.1 A0A7P0T9Y3 ENST00000645149.2 Q14204 A0A7P0T942 ENST00000680423.1 A0A7P0T9K2 A0A7P0TA13 A0A7P0TB75 ENST00000360184.10 A0A7P0T934 A0A7P0T990 A0A7P0TAM4 A0A7P0TBJ7 A0A7P0TAF3 ENST00000681574.1 ENST00000681822.1 ENST00000644881.2 A0A7P0T8W5 ENST00000680313.1 A0A7P0T9S3 A0A7P0TAS7 ENST00000680874.1 A0A2R8YGC7 A0A2R8YFZ7 ENST00000680001.1 ENST00000680715.1 A0A7P0TB96 ENST00000681668.1 ENST00000680200.1 ENST00000681010.1 ENST00000681751.1 Q6P2H7 ENST00000643508.2 ENST00000684561.1 A0A7P0TAW9 A0A7P0TBC9 ENST00000679629.1 ENST00000681066.1 ENST00000680808.1 ENST00000643958.2 A0A7P0T7V5 ENST00000679720.1 ENST00000645039.2 ENST00000679486.1 ENST00000680137.1 ENST00000645114.2

DYNC1H1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review