DCXR | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	28 studies	30% ± 9%	Explore
CD4-positive, alpha-beta T cell	23 studies	27% ± 7%	Explore
T cell	22 studies	25% ± 6%	Explore
conventional dendritic cell	20 studies	28% ± 14%	Explore
CD8-positive, alpha-beta T cell	20 studies	29% ± 8%	Explore
B cell	19 studies	26% ± 6%	Explore
regulatory T cell	16 studies	25% ± 4%	Explore
fibroblast	15 studies	24% ± 10%	Explore
memory B cell	15 studies	22% ± 5%	Explore
basal cell	15 studies	30% ± 16%	Explore
gamma-delta T cell	15 studies	29% ± 12%	Explore
mature NK T cell	14 studies	26% ± 7%	Explore
naive B cell	14 studies	21% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	29% ± 8%	Explore
epithelial cell	13 studies	35% ± 17%	Explore
macrophage	13 studies	24% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	29% ± 5%	Explore
classical monocyte	11 studies	25% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	25% ± 6%	Explore
non-classical monocyte	11 studies	28% ± 8%	Explore
pericyte	11 studies	18% ± 3%	Explore
plasma cell	10 studies	29% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	28% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	26% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	25% ± 8%	Explore
plasmacytoid dendritic cell	9 studies	29% ± 10%	Explore
goblet cell	9 studies	24% ± 9%	Explore
mast cell	9 studies	21% ± 5%	Explore
type II pneumocyte	8 studies	52% ± 20%	Explore
secretory cell	8 studies	31% ± 13%	Explore
endothelial cell	8 studies	23% ± 5%	Explore
mucosal invariant T cell	8 studies	22% ± 3%	Explore
myofibroblast cell	8 studies	21% ± 7%	Explore
smooth muscle cell	8 studies	20% ± 4%	Explore
club cell	7 studies	33% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	25% ± 4%	Explore
monocyte	7 studies	24% ± 12%	Explore
abnormal cell	7 studies	29% ± 15%	Explore
dendritic cell	7 studies	37% ± 15%	Explore
type I pneumocyte	6 studies	25% ± 13%	Explore
respiratory goblet cell	6 studies	30% ± 14%	Explore
epithelial cell of proximal tubule	6 studies	55% ± 15%	Explore
connective tissue cell	6 studies	23% ± 5%	Explore
innate lymphoid cell	6 studies	22% ± 4%	Explore
myeloid cell	6 studies	22% ± 10%	Explore
astrocyte	6 studies	27% ± 8%	Explore
ciliated cell	6 studies	37% ± 12%	Explore
T follicular helper cell	6 studies	27% ± 3%	Explore
hepatocyte	6 studies	54% ± 28%	Explore
hematopoietic precursor cell	5 studies	30% ± 10%	Explore
plasmablast	5 studies	45% ± 23%	Explore
ionocyte	5 studies	25% ± 9%	Explore
kidney loop of Henle epithelial cell	5 studies	41% ± 10%	Explore
renal alpha-intercalated cell	5 studies	40% ± 14%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	29% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	32% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	24% ± 4%	Explore
pancreatic A cell	4 studies	26% ± 6%	Explore
type B pancreatic cell	4 studies	29% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	34% ± 11%	Explore
transit amplifying cell	4 studies	22% ± 3%	Explore
retinal ganglion cell	4 studies	54% ± 28%	Explore
erythroblast	4 studies	34% ± 22%	Explore
precursor B cell	4 studies	27% ± 7%	Explore
immature B cell	4 studies	26% ± 9%	Explore
progenitor cell	4 studies	21% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	53% ± 13%	Explore
adipocyte	4 studies	27% ± 15%	Explore
luminal cell of prostate epithelium	4 studies	40% ± 7%	Explore
oligodendrocyte precursor cell	4 studies	26% ± 12%	Explore
erythrocyte	4 studies	30% ± 18%	Explore
duct epithelial cell	3 studies	36% ± 12%	Explore
mononuclear phagocyte	3 studies	29% ± 17%	Explore
leukocyte	3 studies	26% ± 8%	Explore
extravillous trophoblast	3 studies	54% ± 16%	Explore
common myeloid progenitor	3 studies	30% ± 13%	Explore
hematopoietic stem cell	3 studies	21% ± 3%	Explore
neuroendocrine cell	3 studies	28% ± 5%	Explore
enterocyte	3 studies	19% ± 3%	Explore
pro-B cell	3 studies	21% ± 4%	Explore
retina horizontal cell	3 studies	29% ± 9%	Explore
retinal cone cell	3 studies	27% ± 5%	Explore
retinal rod cell	3 studies	19% ± 3%	Explore
alveolar macrophage	3 studies	21% ± 2%	Explore
serous secreting cell	3 studies	57% ± 21%	Explore
intraepithelial lymphocyte	3 studies	32% ± 9%	Explore
Mueller cell	3 studies	35% ± 13%	Explore
germinal center B cell	3 studies	22% ± 2%	Explore
exhausted T cell	3 studies	27% ± 6%	Explore
intermediate monocyte	3 studies	30% ± 10%	Explore
group 3 innate lymphoid cell	3 studies	39% ± 11%	Explore
T-helper 1 cell	3 studies	25% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	21% ± 5%	Explore
double negative thymocyte	3 studies	31% ± 8%	Explore
progenitor cell of mammary luminal epithelium	3 studies	35% ± 7%	Explore
neuron	3 studies	29% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	14 studies	26% ± 11%	Explore
peripheral blood	13 studies	25% ± 5%	Explore
kidney	8 studies	28% ± 13%	Explore
liver	6 studies	37% ± 20%	Explore
intestine	6 studies	21% ± 7%	Explore
eye	5 studies	23% ± 5%	Explore
lymph node	4 studies	25% ± 2%	Explore
pancreas	3 studies	27% ± 5%	Explore
uterus	3 studies	30% ± 14%	Explore
prostate	3 studies	25% ± 4%	Explore
brain	3 studies	24% ± 4%	Explore
breast	3 studies	29% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	7182.71	245 / 245	100%	543.16	501 / 502
ovary	100%	3396.03	180 / 180	100%	140.59	429 / 430
brain	100%	3808.12	2639 / 2642	100%	126.80	704 / 705
liver	100%	37104.67	226 / 226	99%	787.91	401 / 406
esophagus	100%	2766.41	1441 / 1445	99%	77.06	181 / 183
intestine	99%	2023.33	960 / 966	98%	104.83	518 / 527
uterus	99%	2040.06	169 / 170	98%	108.00	451 / 459
skin	100%	2851.64	1804 / 1809	98%	97.80	462 / 472
breast	100%	4767.88	458 / 459	97%	152.40	1090 / 1118
stomach	100%	5084.04	359 / 359	97%	105.59	278 / 286
thymus	100%	3135.85	652 / 653	97%	87.09	587 / 605
bladder	100%	2373.38	21 / 21	97%	118.19	488 / 504
adrenal gland	100%	2055.56	258 / 258	97%	93.12	222 / 230
lung	99%	2899.45	573 / 578	96%	91.95	1107 / 1155
pancreas	99%	1854.76	326 / 328	95%	57.89	169 / 178
kidney	100%	7300.49	89 / 89	80%	67.26	722 / 901
eye	0%	0	0 / 0	100%	136.27	80 / 80
lymph node	0%	0	0 / 0	100%	121.32	29 / 29
muscle	100%	4560.86	803 / 803	0%	0	0 / 0
spleen	100%	1795.14	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	111.08	1 / 1
adipose	100%	4205.98	1203 / 1204	0%	0	0 / 0
blood vessel	98%	2142.01	1311 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	84.12	44 / 45
heart	98%	3320.06	840 / 861	0%	0	0 / 0
peripheral blood	89%	1495.98	831 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0005997	Biological process	xylulose metabolic process
GO_0006739	Biological process	NADP metabolic process
GO_0019640	Biological process	glucuronate catabolic process to xylulose 5-phosphate
GO_2000379	Biological process	positive regulation of reactive oxygen species metabolic process
GO_0042732	Biological process	D-xylose metabolic process
GO_0006006	Biological process	glucose metabolic process
GO_0005903	Cellular component	brush border
GO_0005902	Cellular component	microvillus
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005881	Cellular component	cytoplasmic microtubule
GO_0005886	Cellular component	plasma membrane
GO_0005634	Cellular component	nucleus
GO_0004090	Molecular function	carbonyl reductase (NADPH) activity
GO_0050038	Molecular function	L-xylulose reductase (NADPH) activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0016655	Molecular function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

IV. Literature review

[source]

Gene name	DCXR
Protein name	L-xylulose reductase (XR) (EC 1.1.1.10) (Carbonyl reductase II) (Dicarbonyl/L-xylulose reductase) (Kidney dicarbonyl reductase) (kiDCR) (Short chain dehydrogenase/reductase family 20C member 1) (Sperm surface protein P34H) L-xylulose reductase (EC 1.1.1.10) (Dicarbonyl/L-xylulose reductase) Dicarbonyl and L-xylulose reductase
Synonyms	hCG_40598 SDR20C1
Description	FUNCTION: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. FUNCTION: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. . FUNCTION: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. . FUNCTION: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. . FUNCTION: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. . FUNCTION: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. . FUNCTION: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. . FUNCTION: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. .
Accessions	Q7Z4W1 ENST00000306869.7 ENST00000577532.5 ENST00000579004.1 J3QS45 ENST00000581584.5 J3KRZ4 J3QRQ2 J3QS36 ENST00000579821.5 ENST00000577712.5 A0A384NY14 ENST00000582900.5 ENST00000579155.1 J3KS22 J3KSZ5 J3QL34

DCXR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review