DCTN3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	32 studies	29% ± 10%	Explore
fibroblast	26 studies	30% ± 13%	Explore
T cell	22 studies	25% ± 7%	Explore
smooth muscle cell	22 studies	30% ± 10%	Explore
CD8-positive, alpha-beta T cell	21 studies	29% ± 13%	Explore
endothelial cell	21 studies	28% ± 11%	Explore
pericyte	20 studies	30% ± 9%	Explore
CD4-positive, alpha-beta T cell	19 studies	27% ± 12%	Explore
non-classical monocyte	18 studies	30% ± 16%	Explore
regulatory T cell	18 studies	25% ± 7%	Explore
B cell	17 studies	23% ± 6%	Explore
classical monocyte	17 studies	27% ± 13%	Explore
conventional dendritic cell	14 studies	28% ± 17%	Explore
monocyte	14 studies	22% ± 8%	Explore
plasmacytoid dendritic cell	14 studies	27% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	32% ± 10%	Explore
ciliated cell	13 studies	35% ± 14%	Explore
myofibroblast cell	13 studies	30% ± 10%	Explore
gamma-delta T cell	13 studies	29% ± 14%	Explore
endothelial cell of lymphatic vessel	12 studies	24% ± 8%	Explore
mature NK T cell	12 studies	27% ± 7%	Explore
connective tissue cell	12 studies	34% ± 8%	Explore
mast cell	11 studies	21% ± 4%	Explore
plasma cell	11 studies	29% ± 12%	Explore
basal cell	11 studies	29% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	22% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	27% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	32% ± 7%	Explore
macrophage	10 studies	23% ± 9%	Explore
mucosal invariant T cell	9 studies	24% ± 4%	Explore
capillary endothelial cell	8 studies	20% ± 3%	Explore
abnormal cell	8 studies	26% ± 12%	Explore
plasmablast	7 studies	42% ± 25%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	29% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	32% ± 14%	Explore
naive B cell	7 studies	19% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	28% ± 9%	Explore
endothelial cell of artery	7 studies	21% ± 4%	Explore
dendritic cell	7 studies	43% ± 27%	Explore
memory B cell	7 studies	19% ± 3%	Explore
epithelial cell	7 studies	43% ± 16%	Explore
neuron	7 studies	46% ± 27%	Explore
endothelial cell of vascular tree	7 studies	24% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	37% ± 12%	Explore
epithelial cell of proximal tubule	6 studies	23% ± 4%	Explore
hematopoietic precursor cell	5 studies	33% ± 18%	Explore
secretory cell	5 studies	26% ± 13%	Explore
leukocyte	5 studies	24% ± 9%	Explore
kidney loop of Henle epithelial cell	5 studies	25% ± 6%	Explore
mesothelial cell	5 studies	38% ± 17%	Explore
vein endothelial cell	5 studies	23% ± 6%	Explore
T follicular helper cell	5 studies	23% ± 3%	Explore
exhausted T cell	4 studies	41% ± 13%	Explore
retinal ganglion cell	4 studies	66% ± 24%	Explore
precursor B cell	4 studies	28% ± 10%	Explore
pro-B cell	4 studies	26% ± 2%	Explore
amacrine cell	4 studies	41% ± 18%	Explore
erythrocyte	4 studies	31% ± 21%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	43% ± 8%	Explore
innate lymphoid cell	4 studies	24% ± 6%	Explore
glutamatergic neuron	4 studies	28% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	37% ± 12%	Explore
oligodendrocyte precursor cell	4 studies	25% ± 7%	Explore
enteroendocrine cell	4 studies	31% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	25% ± 7%	Explore
pancreatic A cell	3 studies	49% ± 12%	Explore
type B pancreatic cell	3 studies	37% ± 14%	Explore
mononuclear phagocyte	3 studies	28% ± 12%	Explore
glomerular endothelial cell	3 studies	19% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	25% ± 1%	Explore
renal alpha-intercalated cell	3 studies	35% ± 6%	Explore
neural crest cell	3 studies	30% ± 5%	Explore
retinal bipolar neuron	3 studies	41% ± 17%	Explore
OFF-bipolar cell	3 studies	42% ± 23%	Explore
lymphocyte	3 studies	34% ± 12%	Explore
myeloid cell	3 studies	31% ± 12%	Explore
club cell	3 studies	24% ± 3%	Explore
type I pneumocyte	3 studies	29% ± 7%	Explore
type II pneumocyte	3 studies	27% ± 11%	Explore
astrocyte	3 studies	34% ± 14%	Explore
retina horizontal cell	3 studies	47% ± 17%	Explore
retinal cone cell	3 studies	54% ± 13%	Explore
retinal rod cell	3 studies	35% ± 9%	Explore
intraepithelial lymphocyte	3 studies	29% ± 11%	Explore
Mueller cell	3 studies	32% ± 9%	Explore
germinal center B cell	3 studies	22% ± 3%	Explore
intermediate monocyte	3 studies	42% ± 20%	Explore
myoepithelial cell	3 studies	30% ± 8%	Explore
glial cell	3 studies	31% ± 20%	Explore
group 3 innate lymphoid cell	3 studies	32% ± 15%	Explore
keratinocyte	3 studies	22% ± 6%	Explore
T-helper 17 cell	3 studies	30% ± 14%	Explore
T-helper 1 cell	3 studies	28% ± 6%	Explore
double negative thymocyte	3 studies	41% ± 14%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	24% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	15 studies	28% ± 10%	Explore
lung	11 studies	29% ± 12%	Explore
kidney	7 studies	24% ± 3%	Explore
eye	7 studies	30% ± 14%	Explore
intestine	6 studies	26% ± 12%	Explore
uterus	4 studies	33% ± 14%	Explore
brain	4 studies	23% ± 5%	Explore
pancreas	3 studies	40% ± 16%	Explore
bone marrow	3 studies	21% ± 3%	Explore
lymph node	3 studies	28% ± 6%	Explore
liver	3 studies	37% ± 26%	Explore
breast	3 studies	20% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2961.21	1445 / 1445	100%	25.46	183 / 183
ovary	100%	2899.16	180 / 180	100%	49.76	430 / 430
uterus	100%	2942.79	170 / 170	100%	48.59	459 / 459
brain	100%	3613.54	2640 / 2642	100%	73.64	705 / 705
thymus	100%	3078.17	653 / 653	100%	52.79	603 / 605
prostate	100%	2810.37	245 / 245	100%	48.08	500 / 502
skin	100%	3433.63	1809 / 1809	100%	40.20	470 / 472
pancreas	100%	1599.58	328 / 328	99%	36.91	177 / 178
lung	100%	2239.63	577 / 578	100%	34.20	1150 / 1155
stomach	100%	2175.65	359 / 359	99%	31.42	284 / 286
intestine	100%	2448.39	966 / 966	99%	35.51	523 / 527
kidney	100%	2805.67	89 / 89	99%	35.31	894 / 901
breast	100%	2669.37	459 / 459	99%	43.72	1109 / 1118
liver	100%	1331.96	226 / 226	99%	28.73	401 / 406
bladder	100%	2479.90	21 / 21	99%	40.29	497 / 504
adrenal gland	100%	2974.71	258 / 258	98%	61.85	226 / 230
adipose	100%	2447.34	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	44.32	80 / 80
lymph node	0%	0	0 / 0	100%	57.71	29 / 29
spleen	100%	2374.22	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	49.61	45 / 45
ureter	0%	0	0 / 0	100%	11.89	1 / 1
blood vessel	100%	2749.96	1334 / 1335	0%	0	0 / 0
muscle	100%	2693.81	802 / 803	0%	0	0 / 0
heart	99%	2594.38	852 / 861	0%	0	0 / 0
peripheral blood	98%	1956.43	915 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007017	Biological process	microtubule-based process
GO_0061640	Biological process	cytoskeleton-dependent cytokinesis
GO_0000278	Biological process	mitotic cell cycle
GO_0005730	Cellular component	nucleolus
GO_0005813	Cellular component	centrosome
GO_0000776	Cellular component	kinetochore
GO_0005869	Cellular component	dynactin complex
GO_0032154	Cellular component	cleavage furrow
GO_0030496	Cellular component	midbody
GO_0005829	Cellular component	cytosol
GO_0005819	Cellular component	spindle
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005515	Molecular function	protein binding
GO_0005198	Molecular function	structural molecule activity

IV. Literature review

[source]

Gene name	DCTN3
Protein name	Dynactin subunit 3 Dynactin 3 (P22), isoform CRA_a (cDNA FLJ34342 fis, clone FEBRA2009986, moderately similar to Dynactin 3 (p22); dynactin light chain) Dynactin subunit 3 (Dynactin complex subunit 22 kDa subunit) (p22)
Synonyms	hCG_20473 DCTN22
Description	FUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Together with dynein may be involved in spindle assembly and cytokinesis . .
Accessions	ENST00000378911.3 X6RCK5 A0A0A0MRV8 ENST00000477738.6 ENST00000378916.8 [O75935-3] O75935 X6RA56 ENST00000341694.6 [O75935-2] ENST00000378913.6 ENST00000421919.5 X6RLR1 Q8NB28 ENST00000259632.12 [O75935-1]

DCTN3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review