CLNS1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006884Biological processcell volume homeostasis
GO_0048026Biological processpositive regulation of mRNA splicing, via spliceosome
GO_0006821Biological processchloride transport
GO_0000387Biological processspliceosomal snRNP assembly
GO_0045292Biological processmRNA cis splicing, via spliceosome
GO_0034709Cellular componentmethylosome
GO_0034715Cellular componentpICln-Sm protein complex
GO_0005856Cellular componentcytoskeleton
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005681Cellular componentspliceosomal complex
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameCLNS1A
Protein nameChloride nucleotide-sensitive channel 1A
Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln)
Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln)
SynonymsICLN
CLCI
DescriptionFUNCTION: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins . Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs . Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) . In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP . Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus . .

AccessionsE9PJF4
E9PQ83
E9PMI6
ENST00000525428.6
ENST00000263309.7
ENST00000526009.5
P54105
ENST00000528364.1
ENST00000526761.5
H0YEN9
U3KPU0
J3KN38
ENST00000532069.5
ENST00000525064.5
ENST00000527133.2