CIAO2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097428Biological processprotein maturation by iron-sulfur cluster transfer
GO_0016226Biological processiron-sulfur cluster assembly
GO_0007059Biological processchromosome segregation
GO_0106035Biological processprotein maturation by [4Fe-4S] cluster transfer
GO_0071817Cellular componentMMXD complex
GO_0097361Cellular componentcytosolic [4Fe-4S] assembly targeting complex
GO_0030496Cellular componentmidbody
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005819Cellular componentspindle
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCIAO2B
Protein nameCytosolic iron-sulfur assembly component 2B
Cytosolic iron-sulfur assembly component 2B (MSS19-interacting protein of 18 kDa) (Mitotic spindle-associated MMXD complex subunit MIP18) (Protein FAM96B)
SynonymsCIAB
CGI-128
HSPC118
FAM96B
MIP18
DescriptionFUNCTION: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins . As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins . As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD . Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis . .

AccessionsH3BNV7
ENST00000562362.5
ENST00000567511.1
ENST00000568572.5
J3QLT9
J3KS95
Q9Y3D0
ENST00000422424.7