CELF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006376Biological processmRNA splice site recognition
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0008016Biological processregulation of heart contraction
GO_0006396Biological processRNA processing
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0090543Cellular componentFlemming body
GO_0005737Cellular componentcytoplasm
GO_0005654Cellular componentnucleoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0036002Molecular functionpre-mRNA binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameCELF2
Protein nameCUGBP Elav-like family member 2
CUGBP Elav-like family member 2 (CELF-2) (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP2) (CUG-BP- and ETR-3-like factor 2) (ELAV-type RNA-binding protein 3) (ETR-3) (Neuroblastoma apoptosis-related RNA-binding protein) (hNAPOR) (RNA-binding protein BRUNOL-3)
CUGBP Elav-like family member 2 (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP- and ETR-3-like factor 2) (RNA-binding protein BRUNOL-3)
SynonymsETR3
BRUNOL3
NAPOR
CUGBP2
DescriptionFUNCTION: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediately upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity). May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA . .

AccessionsENST00000399850.7 [O95319-2]
ENST00000631816.1
ENST00000632065.1
A0A0J9YXJ0
A0A0J9YX66
O95319
ENST00000638035.1 [O95319-2]
A0A0J9YXK1
ENST00000542579.5
ENST00000633200.1
V9GY47
ENST00000633077.2
A0A1B0GUN8
V9GYD9
ENST00000637215.1
A0A1B0GU44
ENST00000416382.6 [O95319-1]
ENST00000354897.3
ENST00000608830.5 [O95319-5]
ENST00000636488.1
ENST00000609692.5
ENST00000631460.1 [O95319-1]
E9PC62
Q5VZZ6
ENST00000632728.1 [O95319-2]
ENST00000609870.5
ENST00000417956.6 [O95319-2]