AUP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	26 studies	30% ± 9%	Explore
B cell	24 studies	27% ± 9%	Explore
macrophage	23 studies	27% ± 9%	Explore
CD4-positive, alpha-beta T cell	22 studies	26% ± 7%	Explore
endothelial cell	22 studies	27% ± 10%	Explore
conventional dendritic cell	20 studies	31% ± 15%	Explore
CD8-positive, alpha-beta T cell	20 studies	28% ± 7%	Explore
memory B cell	18 studies	31% ± 8%	Explore
non-classical monocyte	18 studies	33% ± 13%	Explore
fibroblast	18 studies	24% ± 9%	Explore
classical monocyte	17 studies	28% ± 11%	Explore
regulatory T cell	17 studies	33% ± 5%	Explore
plasma cell	15 studies	44% ± 18%	Explore
naive B cell	15 studies	27% ± 8%	Explore
T cell	14 studies	24% ± 4%	Explore
gamma-delta T cell	14 studies	28% ± 8%	Explore
epithelial cell	14 studies	32% ± 19%	Explore
plasmacytoid dendritic cell	13 studies	33% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	32% ± 8%	Explore
monocyte	13 studies	25% ± 8%	Explore
mature NK T cell	12 studies	29% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	32% ± 7%	Explore
plasmablast	11 studies	47% ± 23%	Explore
pericyte	11 studies	24% ± 6%	Explore
endothelial cell of lymphatic vessel	10 studies	30% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	27% ± 7%	Explore
basal cell	10 studies	31% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	24% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	27% ± 2%	Explore
capillary endothelial cell	10 studies	24% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	30% ± 6%	Explore
connective tissue cell	9 studies	22% ± 5%	Explore
dendritic cell	9 studies	46% ± 21%	Explore
mucosal invariant T cell	9 studies	29% ± 3%	Explore
mast cell	8 studies	19% ± 3%	Explore
type I pneumocyte	8 studies	27% ± 10%	Explore
goblet cell	8 studies	25% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	28% ± 6%	Explore
myofibroblast cell	7 studies	22% ± 5%	Explore
endothelial cell of artery	7 studies	19% ± 3%	Explore
vein endothelial cell	7 studies	23% ± 8%	Explore
myeloid cell	7 studies	35% ± 9%	Explore
abnormal cell	7 studies	36% ± 16%	Explore
innate lymphoid cell	6 studies	27% ± 7%	Explore
secretory cell	6 studies	27% ± 5%	Explore
precursor B cell	6 studies	32% ± 9%	Explore
ciliated cell	6 studies	28% ± 7%	Explore
T follicular helper cell	6 studies	26% ± 6%	Explore
progenitor cell	5 studies	19% ± 5%	Explore
smooth muscle cell	5 studies	26% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	33% ± 5%	Explore
endothelial cell of vascular tree	5 studies	26% ± 5%	Explore
erythrocyte	5 studies	27% ± 16%	Explore
hematopoietic precursor cell	4 studies	35% ± 9%	Explore
club cell	4 studies	30% ± 9%	Explore
exhausted T cell	4 studies	31% ± 2%	Explore
IgA plasma cell	4 studies	26% ± 9%	Explore
IgG plasma cell	4 studies	26% ± 10%	Explore
pro-B cell	4 studies	23% ± 5%	Explore
immature B cell	4 studies	30% ± 9%	Explore
type II pneumocyte	4 studies	27% ± 11%	Explore
alveolar macrophage	4 studies	19% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	35% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	32% ± 4%	Explore
enterocyte	4 studies	21% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	28% ± 5%	Explore
respiratory goblet cell	3 studies	36% ± 17%	Explore
squamous epithelial cell	3 studies	32% ± 23%	Explore
pancreatic A cell	3 studies	40% ± 10%	Explore
type B pancreatic cell	3 studies	41% ± 10%	Explore
mononuclear phagocyte	3 studies	33% ± 15%	Explore
leukocyte	3 studies	23% ± 6%	Explore
common myeloid progenitor	3 studies	31% ± 18%	Explore
hematopoietic stem cell	3 studies	28% ± 5%	Explore
lymphocyte	3 studies	26% ± 7%	Explore
astrocyte	3 studies	25% ± 7%	Explore
microglial cell	3 studies	30% ± 5%	Explore
serous secreting cell	3 studies	21% ± 3%	Explore
erythroblast	3 studies	35% ± 19%	Explore
germinal center B cell	3 studies	26% ± 8%	Explore
intermediate monocyte	3 studies	40% ± 16%	Explore
pancreatic ductal cell	3 studies	54% ± 14%	Explore
oligodendrocyte precursor cell	3 studies	28% ± 9%	Explore
enteroendocrine cell	3 studies	30% ± 11%	Explore
group 3 innate lymphoid cell	3 studies	33% ± 7%	Explore
transit amplifying cell	3 studies	18% ± 1%	Explore
T-helper 1 cell	3 studies	29% ± 5%	Explore
T-helper 17 cell	3 studies	25% ± 10%	Explore
double negative thymocyte	3 studies	36% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	24% ± 8%	Explore
neuron	3 studies	32% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	15 studies	29% ± 6%	Explore
lung	11 studies	27% ± 7%	Explore
intestine	8 studies	21% ± 9%	Explore
liver	5 studies	26% ± 18%	Explore
pancreas	4 studies	37% ± 14%	Explore
lymph node	4 studies	32% ± 10%	Explore
brain	4 studies	33% ± 4%	Explore
kidney	3 studies	26% ± 8%	Explore
placenta	3 studies	23% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6158.05	1445 / 1445	100%	163.09	183 / 183
liver	100%	6860.42	226 / 226	100%	189.36	406 / 406
ovary	100%	6053.90	180 / 180	100%	217.27	430 / 430
pancreas	100%	6562.23	328 / 328	100%	199.72	178 / 178
skin	100%	5923.50	1809 / 1809	100%	255.27	472 / 472
thymus	100%	7963.62	653 / 653	100%	157.41	605 / 605
uterus	100%	6964.12	170 / 170	100%	244.88	459 / 459
lung	100%	7223.96	578 / 578	100%	220.23	1153 / 1155
stomach	100%	6562.76	359 / 359	100%	193.86	285 / 286
brain	100%	4015.18	2632 / 2642	100%	174.32	705 / 705
intestine	100%	7197.36	966 / 966	100%	220.89	525 / 527
bladder	100%	6650.29	21 / 21	100%	259.61	502 / 504
prostate	100%	7807.66	245 / 245	100%	187.79	500 / 502
adrenal gland	100%	6301.04	258 / 258	100%	137.62	229 / 230
kidney	100%	6094.36	89 / 89	100%	145.52	897 / 901
breast	100%	6341.68	459 / 459	100%	192.16	1113 / 1118
adipose	100%	6475.46	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	230.97	80 / 80
lymph node	0%	0	0 / 0	100%	219.68	29 / 29
spleen	100%	10384.70	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	179.95	45 / 45
ureter	0%	0	0 / 0	100%	182.57	1 / 1
heart	100%	3892.71	860 / 861	0%	0	0 / 0
muscle	100%	4933.98	802 / 803	0%	0	0 / 0
blood vessel	100%	5373.13	1333 / 1335	0%	0	0 / 0
peripheral blood	99%	5507.76	920 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0009615	Biological process	response to virus
GO_0140042	Biological process	lipid droplet formation
GO_1990044	Biological process	protein localization to lipid droplet
GO_0030970	Biological process	retrograde protein transport, ER to cytosol
GO_0061724	Biological process	lipophagy
GO_0034389	Biological process	lipid droplet organization
GO_0036503	Biological process	ERAD pathway
GO_0070062	Cellular component	extracellular exosome
GO_0005783	Cellular component	endoplasmic reticulum
GO_0016020	Cellular component	membrane
GO_0005811	Cellular component	lipid droplet
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0005776	Cellular component	autophagosome
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0043130	Molecular function	ubiquitin binding
GO_0005515	Molecular function	protein binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0031624	Molecular function	ubiquitin conjugating enzyme binding

IV. Literature review

[source]

Gene name	AUP1
Protein name	Lipid droplet-regulating VLDL assembly factor AUP1 (Ancient ubiquitous protein 1)
Synonyms
Description	FUNCTION: Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome . Plays a role in lipid droplet formation . Induces lipid droplet clustering . Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation . Also required for the degradation of INSIG1, SREBF1 and SREBF2 . Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB . .; FUNCTION: (Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles. .
Accessions	Q9Y679 ENST00000377526.4 [Q9Y679-2] ENST00000425118.5 [Q9Y679-3]

AUP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review