ARID1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030071Biological processregulation of mitotic metaphase/anaphase transition
GO_0002931Biological processresponse to ischemia
GO_0045582Biological processpositive regulation of T cell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0045663Biological processpositive regulation of myoblast differentiation
GO_0006338Biological processchromatin remodeling
GO_0070316Biological processregulation of G0 to G1 transition
GO_0045597Biological processpositive regulation of cell differentiation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_2000819Biological processregulation of nucleotide-excision repair
GO_2000781Biological processpositive regulation of double-strand break repair
GO_0007399Biological processnervous system development
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_1904385Biological processcellular response to angiotensin
GO_0071565Cellular componentnBAF complex
GO_0005886Cellular componentplasma membrane
GO_0071564Cellular componentnpBAF complex
GO_0016514Cellular componentSWI/SNF complex
GO_0005654Cellular componentnucleoplasm
GO_0035060Cellular componentbrahma complex
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0140092Cellular componentbBAF complex
GO_0003677Molecular functionDNA binding
GO_0031491Molecular functionnucleosome binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameARID1B
Protein nameAT-rich interactive domain-containing protein 1B (ARID domain-containing protein 1B) (BRG1-associated factor 250b) (BAF250B) (BRG1-binding protein hELD/OSA1) (Osa homolog 2) (hOsa2) (p250R)
Alternative protein ARID1B
AT-rich interaction domain 1B
AT-rich interactive domain-containing protein 1B
SynonymsKIAA1235
BAF250B
OSA2
DAN15
DescriptionFUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically . .

AccessionsA0A8J9GB59
H0Y3S9
ENST00000346085.10 [Q8NFD5-2]
H0Y7H8
A0A1B0GVK1
ENST00000636607.1
ENST00000638000.1
A0A1B0GU65
ENST00000637568.1
ENST00000637887.1
A0A1B0GTE8
ENST00000636748.1
ENST00000494260.2
A0A1B0GVH0
ENST00000319584.11
ENST00000637532.1
A0A1B0GWJ2
A0A6Q8NVI4
ENST00000674298.1
ENST00000400790.3
L8EAX2
ENST00000636930.2 [Q8NFD5-3]
A0A3F2YNW7
ENST00000636930.2
A0A6I8PTU7
ENST00000637003.1
ENST00000637015.2
ENST00000414678.8
A0A1B0GUG2
A0A1B0GV92
A0A1B0GV63
ENST00000637904.1
ENST00000635928.1
A0A1B0GUC6
Q8NFD5
A0A1B0GTJ8
ENST00000346085.10
A0A1B0GTI6
A0A1B0GU09
A0A1B0GWI8
ENST00000637810.1
ENST00000350026.11 [Q8NFD5-5]
H0Y2R3
ENST00000635849.1
ENST00000635957.1