XRN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	28 studies	33% ± 15%	Explore
natural killer cell	21 studies	25% ± 7%	Explore
fibroblast	15 studies	28% ± 13%	Explore
astrocyte	15 studies	35% ± 17%	Explore
CD8-positive, alpha-beta T cell	15 studies	23% ± 5%	Explore
T cell	14 studies	24% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	23% ± 5%	Explore
oligodendrocyte precursor cell	13 studies	37% ± 19%	Explore
microglial cell	13 studies	35% ± 13%	Explore
B cell	12 studies	23% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	24% ± 4%	Explore
CD4-positive, alpha-beta T cell	12 studies	21% ± 5%	Explore
macrophage	12 studies	33% ± 14%	Explore
regulatory T cell	12 studies	22% ± 3%	Explore
gamma-delta T cell	12 studies	22% ± 4%	Explore
oligodendrocyte	11 studies	37% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	21% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	19% ± 4%	Explore
glutamatergic neuron	10 studies	49% ± 26%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	23% ± 4%	Explore
mucosal invariant T cell	10 studies	22% ± 3%	Explore
naive B cell	9 studies	19% ± 3%	Explore
GABAergic neuron	9 studies	49% ± 24%	Explore
mature NK T cell	9 studies	23% ± 5%	Explore
pericyte	9 studies	30% ± 12%	Explore
plasma cell	8 studies	36% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	24% ± 5%	Explore
monocyte	8 studies	28% ± 8%	Explore
epithelial cell	8 studies	37% ± 16%	Explore
ciliated cell	8 studies	25% ± 9%	Explore
adipocyte	8 studies	31% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	20% ± 3%	Explore
mast cell	7 studies	24% ± 8%	Explore
endothelial cell of lymphatic vessel	7 studies	34% ± 12%	Explore
smooth muscle cell	7 studies	26% ± 7%	Explore
myeloid cell	7 studies	25% ± 6%	Explore
type I pneumocyte	6 studies	26% ± 8%	Explore
neuron	6 studies	39% ± 18%	Explore
interneuron	6 studies	53% ± 24%	Explore
dendritic cell	6 studies	29% ± 6%	Explore
basal cell	6 studies	29% ± 20%	Explore
plasmacytoid dendritic cell	6 studies	22% ± 8%	Explore
non-classical monocyte	5 studies	24% ± 7%	Explore
retinal cone cell	5 studies	30% ± 12%	Explore
club cell	5 studies	25% ± 8%	Explore
type II pneumocyte	5 studies	24% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	23% ± 5%	Explore
memory B cell	5 studies	17% ± 1%	Explore
classical monocyte	4 studies	23% ± 6%	Explore
granule cell	4 studies	31% ± 5%	Explore
capillary endothelial cell	4 studies	23% ± 6%	Explore
cardiac muscle cell	4 studies	23% ± 2%	Explore
mesothelial cell	4 studies	31% ± 10%	Explore
lymphocyte	4 studies	41% ± 14%	Explore
Mueller cell	4 studies	28% ± 14%	Explore
amacrine cell	4 studies	30% ± 12%	Explore
retina horizontal cell	4 studies	28% ± 12%	Explore
retinal rod cell	4 studies	37% ± 7%	Explore
respiratory goblet cell	4 studies	29% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	20% ± 5%	Explore
endothelial cell of vascular tree	4 studies	30% ± 18%	Explore
goblet cell	4 studies	35% ± 29%	Explore
erythrocyte	4 studies	41% ± 17%	Explore
leukocyte	3 studies	32% ± 5%	Explore
exhausted T cell	3 studies	24% ± 9%	Explore
plasmablast	3 studies	36% ± 10%	Explore
glomerular endothelial cell	3 studies	18% ± 1%	Explore
GABAergic interneuron	3 studies	37% ± 2%	Explore
vein endothelial cell	3 studies	35% ± 17%	Explore
retinal bipolar neuron	3 studies	24% ± 4%	Explore
GABAergic amacrine cell	3 studies	26% ± 13%	Explore
glycinergic amacrine cell	3 studies	28% ± 7%	Explore
rod bipolar cell	3 studies	32% ± 15%	Explore
secretory cell	3 studies	17% ± 2%	Explore
innate lymphoid cell	3 studies	21% ± 2%	Explore
hepatocyte	3 studies	57% ± 12%	Explore
ependymal cell	3 studies	41% ± 15%	Explore
alveolar macrophage	3 studies	37% ± 9%	Explore
T follicular helper cell	3 studies	19% ± 3%	Explore
muscle cell	3 studies	33% ± 22%	Explore
double negative thymocyte	3 studies	27% ± 7%	Explore
mural cell	3 studies	39% ± 14%	Explore
abnormal cell	3 studies	26% ± 12%	Explore
mucus secreting cell	3 studies	25% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	41% ± 22%	Explore
peripheral blood	10 studies	21% ± 4%	Explore
lung	8 studies	23% ± 8%	Explore
eye	6 studies	35% ± 17%	Explore
heart	4 studies	24% ± 4%	Explore
kidney	4 studies	20% ± 4%	Explore
liver	4 studies	30% ± 12%	Explore
adipose	4 studies	25% ± 9%	Explore
intestine	3 studies	17% ± 0%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2757.07	1445 / 1445	100%	23.85	183 / 183
lung	100%	3905.39	578 / 578	100%	15.71	1152 / 1155
prostate	100%	3176.13	245 / 245	99%	15.05	499 / 502
pancreas	100%	1785.77	328 / 328	99%	11.78	176 / 178
uterus	100%	3768.55	170 / 170	99%	15.95	453 / 459
breast	100%	4091.83	459 / 459	99%	15.96	1103 / 1118
thymus	100%	3274.36	653 / 653	98%	11.14	592 / 605
bladder	100%	3032.67	21 / 21	98%	12.26	492 / 504
stomach	100%	2175.13	359 / 359	97%	13.73	276 / 286
ovary	100%	3683.92	180 / 180	96%	8.56	414 / 430
intestine	100%	3259.46	966 / 966	96%	10.94	506 / 527
kidney	100%	1755.94	89 / 89	96%	12.70	863 / 901
brain	96%	1601.34	2528 / 2642	99%	9.33	699 / 705
adrenal gland	100%	2850.51	258 / 258	91%	6.86	210 / 230
skin	100%	4042.50	1809 / 1809	89%	11.81	419 / 472
liver	100%	2538.65	226 / 226	87%	7.27	355 / 406
blood vessel	100%	3120.19	1335 / 1335	0%	0	0 / 0
muscle	100%	3254.10	803 / 803	0%	0	0 / 0
spleen	100%	3904.08	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	20.92	45 / 45
ureter	0%	0	0 / 0	100%	3.17	1 / 1
adipose	100%	3759.28	1203 / 1204	0%	0	0 / 0
heart	97%	1463.46	833 / 861	0%	0	0 / 0
peripheral blood	96%	3132.12	892 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	13.23	26 / 29
eye	0%	0	0 / 0	40%	2.52	32 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0033574	Biological process	response to testosterone
GO_0071044	Biological process	histone mRNA catabolic process
GO_0071409	Biological process	cellular response to cycloheximide
GO_1905795	Biological process	cellular response to puromycin
GO_0032211	Biological process	negative regulation of telomere maintenance via telomerase
GO_0016075	Biological process	rRNA catabolic process
GO_0071028	Biological process	nuclear mRNA surveillance
GO_0000956	Biological process	nuclear-transcribed mRNA catabolic process
GO_0017148	Biological process	negative regulation of translation
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0043025	Cellular component	neuronal cell body
GO_0030425	Cellular component	dendrite
GO_0000932	Cellular component	P-body
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0051880	Molecular function	G-quadruplex DNA binding
GO_0070034	Molecular function	telomerase RNA binding
GO_0003723	Molecular function	RNA binding
GO_0004534	Molecular function	5'-3' RNA exonuclease activity
GO_0002151	Molecular function	G-quadruplex RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	XRN1
Protein name	5'-3' exoribonuclease 1 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog)
Synonyms	SEP1
Description	FUNCTION: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). .
Accessions	ENST00000486211.1 H7C5E4 ENST00000477237.1 ENST00000489241.1 ENST00000463916.5 [Q8IZH2-3] ENST00000264951.8 [Q8IZH2-1] C9JCZ8 F8WDA0 ENST00000498077.6 ENST00000392981.7 [Q8IZH2-2] H7C583 Q8IZH2

XRN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review