UQCRC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043279Biological processresponse to alkaloid
GO_0006122Biological processmitochondrial electron transport, ubiquinol to cytochrome c
GO_0006119Biological processoxidative phosphorylation
GO_0009060Biological processaerobic respiration
GO_0045333Biological processcellular respiration
GO_0014823Biological processresponse to activity
GO_1902600Biological processproton transmembrane transport
GO_0005746Cellular componentmitochondrial respirasome
GO_0005750Cellular componentmitochondrial respiratory chain complex III
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0044877Molecular functionprotein-containing complex binding
GO_0008121Molecular functionubiquinol-cytochrome-c reductase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameUQCRC1
Protein nameCytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1)
Ubiquinol-cytochrome c reductase core protein 1
Synonyms
DescriptionFUNCTION: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons . .

AccessionsENST00000412343.5
F8WEF1
ENST00000415995.5
F8WER5
P31930
ENST00000203407.6