TSC22D3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	47 studies	66% ± 25%	Explore
natural killer cell	44 studies	66% ± 18%	Explore
fibroblast	43 studies	42% ± 16%	Explore
endothelial cell	41 studies	39% ± 19%	Explore
macrophage	40 studies	42% ± 19%	Explore
T cell	39 studies	56% ± 21%	Explore
CD8-positive, alpha-beta T cell	37 studies	63% ± 18%	Explore
CD4-positive, alpha-beta T cell	33 studies	69% ± 19%	Explore
pericyte	30 studies	42% ± 19%	Explore
conventional dendritic cell	29 studies	53% ± 21%	Explore
mast cell	28 studies	53% ± 24%	Explore
plasma cell	27 studies	54% ± 21%	Explore
classical monocyte	27 studies	54% ± 19%	Explore
dendritic cell	25 studies	49% ± 19%	Explore
monocyte	25 studies	41% ± 16%	Explore
non-classical monocyte	25 studies	66% ± 20%	Explore
regulatory T cell	24 studies	76% ± 14%	Explore
mature NK T cell	23 studies	67% ± 19%	Explore
smooth muscle cell	22 studies	38% ± 17%	Explore
memory B cell	20 studies	79% ± 18%	Explore
naive B cell	20 studies	73% ± 20%	Explore
plasmacytoid dendritic cell	20 studies	53% ± 20%	Explore
gamma-delta T cell	19 studies	68% ± 21%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	19 studies	60% ± 21%	Explore
mucosal invariant T cell	17 studies	65% ± 23%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	70% ± 20%	Explore
basal cell	15 studies	31% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	64% ± 23%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	72% ± 14%	Explore
capillary endothelial cell	14 studies	39% ± 16%	Explore
myofibroblast cell	14 studies	44% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	64% ± 21%	Explore
connective tissue cell	13 studies	43% ± 19%	Explore
endothelial cell of artery	13 studies	40% ± 16%	Explore
neutrophil	12 studies	41% ± 17%	Explore
vein endothelial cell	12 studies	34% ± 11%	Explore
myeloid cell	12 studies	47% ± 18%	Explore
innate lymphoid cell	11 studies	69% ± 24%	Explore
endothelial cell of vascular tree	11 studies	39% ± 17%	Explore
platelet	10 studies	53% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	67% ± 25%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	76% ± 18%	Explore
type II pneumocyte	9 studies	35% ± 15%	Explore
plasmablast	9 studies	57% ± 20%	Explore
leukocyte	9 studies	46% ± 17%	Explore
IgG plasma cell	9 studies	54% ± 18%	Explore
T follicular helper cell	9 studies	63% ± 22%	Explore
epithelial cell	9 studies	37% ± 18%	Explore
ciliated cell	9 studies	26% ± 6%	Explore
alveolar macrophage	8 studies	49% ± 17%	Explore
IgA plasma cell	8 studies	60% ± 17%	Explore
adipocyte	8 studies	29% ± 9%	Explore
type I pneumocyte	7 studies	36% ± 16%	Explore
mononuclear phagocyte	7 studies	48% ± 20%	Explore
hematopoietic stem cell	7 studies	62% ± 19%	Explore
precursor B cell	7 studies	48% ± 19%	Explore
oligodendrocyte	7 studies	24% ± 7%	Explore
endothelial cell of lymphatic vessel	6 studies	23% ± 5%	Explore
CD4-positive helper T cell	6 studies	75% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	58% ± 25%	Explore
hematopoietic precursor cell	6 studies	40% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	62% ± 22%	Explore
podocyte	6 studies	64% ± 26%	Explore
abnormal cell	6 studies	56% ± 25%	Explore
glial cell	6 studies	34% ± 15%	Explore
immature B cell	6 studies	65% ± 16%	Explore
oligodendrocyte precursor cell	6 studies	27% ± 7%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	66% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	55% ± 22%	Explore
kidney loop of Henle epithelial cell	5 studies	32% ± 9%	Explore
astrocyte	5 studies	21% ± 5%	Explore
lymphocyte	5 studies	36% ± 18%	Explore
pro-B cell	5 studies	44% ± 19%	Explore
group 3 innate lymphoid cell	5 studies	78% ± 11%	Explore
adventitial cell	5 studies	43% ± 13%	Explore
secretory cell	5 studies	30% ± 22%	Explore
intermediate monocyte	5 studies	71% ± 27%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	80% ± 8%	Explore
granulocyte	5 studies	67% ± 20%	Explore
melanocyte	5 studies	36% ± 13%	Explore
erythrocyte	4 studies	60% ± 16%	Explore
glomerular endothelial cell	4 studies	69% ± 11%	Explore
epithelial cell of proximal tubule	4 studies	30% ± 18%	Explore
neuron	4 studies	28% ± 11%	Explore
retinal ganglion cell	4 studies	77% ± 23%	Explore
club cell	4 studies	28% ± 10%	Explore
T-helper 17 cell	4 studies	84% ± 8%	Explore
luminal cell of prostate epithelium	4 studies	25% ± 9%	Explore
IgM plasma cell	4 studies	42% ± 15%	Explore
GABAergic neuron	4 studies	20% ± 4%	Explore
glutamatergic neuron	4 studies	28% ± 10%	Explore
double negative thymocyte	4 studies	65% ± 21%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	45% ± 18%	Explore
exhausted T cell	3 studies	42% ± 10%	Explore
squamous epithelial cell	3 studies	40% ± 23%	Explore
monocyte-derived dendritic cell	3 studies	64% ± 28%	Explore
megakaryocyte	3 studies	55% ± 8%	Explore
retinal pigment epithelial cell	3 studies	47% ± 9%	Explore
serous secreting cell	3 studies	21% ± 3%	Explore
mesothelial cell	3 studies	25% ± 7%	Explore
tissue-resident macrophage	3 studies	52% ± 21%	Explore
intraepithelial lymphocyte	3 studies	38% ± 15%	Explore
respiratory goblet cell	3 studies	32% ± 21%	Explore
germinal center B cell	3 studies	47% ± 15%	Explore
inflammatory macrophage	3 studies	32% ± 9%	Explore
muscle cell	3 studies	36% ± 18%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	52% ± 23%	Explore
enteroendocrine cell	3 studies	24% ± 6%	Explore
Schwann cell	3 studies	41% ± 22%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	77% ± 10%	Explore
double-positive, alpha-beta thymocyte	3 studies	73% ± 21%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	21% ± 4%	Explore
parietal epithelial cell	3 studies	35% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	42% ± 18%	Explore
peripheral blood	18 studies	68% ± 17%	Explore
intestine	11 studies	43% ± 29%	Explore
kidney	7 studies	45% ± 21%	Explore
brain	7 studies	28% ± 7%	Explore
eye	5 studies	31% ± 14%	Explore
liver	4 studies	46% ± 23%	Explore
bone marrow	4 studies	42% ± 27%	Explore
heart	4 studies	19% ± 4%	Explore
uterus	4 studies	40% ± 9%	Explore
adipose	4 studies	36% ± 28%	Explore
lymph node	4 studies	76% ± 17%	Explore
breast	4 studies	40% ± 12%	Explore
skin	4 studies	31% ± 8%	Explore
adrenal gland	3 studies	52% ± 27%	Explore
esophagus	3 studies	39% ± 16%	Explore
prostate	3 studies	24% ± 5%	Explore
thymus	3 studies	32% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	98%	18978.96	254 / 258	99%	156.02	227 / 230
thymus	96%	27117.93	627 / 653	100%	154.60	602 / 605
prostate	95%	33878.21	233 / 245	100%	189.19	501 / 502
breast	98%	38813.70	450 / 459	95%	128.47	1064 / 1118
lung	96%	41529.77	552 / 578	93%	115.28	1078 / 1155
uterus	85%	26285.64	144 / 170	90%	77.23	412 / 459
kidney	78%	12894.99	69 / 89	93%	187.90	838 / 901
bladder	90%	43410.71	19 / 21	79%	59.13	396 / 504
skin	86%	29317.53	1560 / 1809	80%	60.23	377 / 472
esophagus	87%	26144.05	1251 / 1445	77%	50.55	140 / 183
stomach	93%	24337.20	334 / 359	70%	41.89	199 / 286
ovary	92%	28283.59	165 / 180	69%	35.99	297 / 430
intestine	89%	25592.63	862 / 966	61%	36.74	319 / 527
brain	39%	4230.89	1037 / 2642	99%	100.96	700 / 705
pancreas	26%	2776.48	85 / 328	94%	175.15	168 / 178
liver	35%	4832.16	80 / 226	66%	58.73	268 / 406
lymph node	0%	0	0 / 0	100%	115.15	29 / 29
ureter	0%	0	0 / 0	100%	68.59	1 / 1
blood vessel	99%	60954.42	1320 / 1335	0%	0	0 / 0
adipose	98%	39539.41	1178 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	96.44	43 / 45
spleen	95%	32222.86	229 / 241	0%	0	0 / 0
muscle	90%	38542.63	719 / 803	0%	0	0 / 0
peripheral blood	86%	42940.61	802 / 929	0%	0	0 / 0
heart	67%	12429.71	573 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	26%	9.27	21 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	TSC22D3
Protein name	TSC22 domain family protein 3 TSC22 domain family protein 3 (DSIP-immunoreactive peptide) (Protein DIP) (hDIP) (Delta sleep-inducing peptide immunoreactor) (Glucocorticoid-induced leucine zipper protein) (GILZ) (TSC-22-like protein) (TSC-22-related protein) (TSC-22R) TSC22 domain family member 3
Synonyms	DSIPI GILZ
Description	FUNCTION: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 . In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 . In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities . In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (By similarity). .; FUNCTION: [Isoform 1]: Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG. .
Accessions	ENST00000506081.5 [Q99576-3] ENST00000315660.8 [Q99576-3] ENST00000372397.6 [Q99576-1] E7EWD5 ENST00000372382.8 Q99576 ENST00000372383.9 [Q99576-3] ENST00000372390.8 [Q99576-5] ENST00000510887.5 D6RDZ7 D6RDZ9 ENST00000503515.1 D6RD37 ENST00000486554.1 A0A8I5KT94 D6RBL1 ENST00000480691.2 Q5JRJ0 ENST00000502961.1 D6R8Z7 ENST00000372384.6 [Q99576-3] D6RCK9 D6RAX8 ENST00000514426.1 ENST00000502650.1 D6R9J1 ENST00000514897.5 D6RD92 ENST00000506724.1 ENST00000688924.1 ENST00000505965.1

GO_0006970	Biological process	response to osmotic stress
GO_0070236	Biological process	negative regulation of activation-induced cell death of T cells
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding

TSC22D3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review