THOC2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	32 studies	30% ± 14%	Explore
pericyte	28 studies	26% ± 12%	Explore
fibroblast	27 studies	25% ± 10%	Explore
B cell	25 studies	23% ± 6%	Explore
natural killer cell	25 studies	21% ± 4%	Explore
smooth muscle cell	25 studies	22% ± 6%	Explore
CD8-positive, alpha-beta T cell	17 studies	20% ± 5%	Explore
memory B cell	17 studies	20% ± 3%	Explore
naive B cell	16 studies	20% ± 4%	Explore
CD4-positive, alpha-beta T cell	16 studies	19% ± 6%	Explore
macrophage	15 studies	30% ± 12%	Explore
T cell	14 studies	20% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	21% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	20% ± 3%	Explore
regulatory T cell	14 studies	18% ± 4%	Explore
astrocyte	13 studies	33% ± 14%	Explore
plasmacytoid dendritic cell	13 studies	24% ± 8%	Explore
type I pneumocyte	12 studies	34% ± 13%	Explore
oligodendrocyte	12 studies	34% ± 11%	Explore
oligodendrocyte precursor cell	12 studies	34% ± 13%	Explore
ciliated cell	12 studies	27% ± 10%	Explore
gamma-delta T cell	12 studies	23% ± 12%	Explore
endothelial cell of lymphatic vessel	11 studies	25% ± 10%	Explore
type II pneumocyte	11 studies	34% ± 15%	Explore
basal cell	11 studies	31% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	19% ± 3%	Explore
epithelial cell	11 studies	39% ± 20%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	19% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	20% ± 5%	Explore
mature NK T cell	10 studies	20% ± 4%	Explore
myofibroblast cell	10 studies	25% ± 9%	Explore
glutamatergic neuron	10 studies	37% ± 23%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	22% ± 4%	Explore
capillary endothelial cell	9 studies	20% ± 4%	Explore
microglial cell	9 studies	32% ± 9%	Explore
mucosal invariant T cell	9 studies	18% ± 1%	Explore
adipocyte	9 studies	26% ± 7%	Explore
monocyte	9 studies	25% ± 7%	Explore
myeloid cell	8 studies	25% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	20% ± 5%	Explore
classical monocyte	7 studies	24% ± 11%	Explore
non-classical monocyte	7 studies	24% ± 8%	Explore
GABAergic neuron	7 studies	42% ± 17%	Explore
connective tissue cell	7 studies	22% ± 6%	Explore
abnormal cell	7 studies	27% ± 12%	Explore
neuron	7 studies	37% ± 16%	Explore
interneuron	7 studies	40% ± 19%	Explore
mast cell	7 studies	27% ± 9%	Explore
retinal cone cell	7 studies	36% ± 12%	Explore
retinal rod cell	7 studies	28% ± 8%	Explore
leukocyte	6 studies	24% ± 5%	Explore
conventional dendritic cell	6 studies	29% ± 17%	Explore
progenitor cell	6 studies	24% ± 6%	Explore
precursor B cell	6 studies	27% ± 9%	Explore
club cell	6 studies	33% ± 9%	Explore
retina horizontal cell	6 studies	25% ± 8%	Explore
dendritic cell	6 studies	33% ± 14%	Explore
endothelial cell of artery	6 studies	17% ± 2%	Explore
endothelial cell of vascular tree	6 studies	25% ± 14%	Explore
hematopoietic precursor cell	5 studies	30% ± 11%	Explore
secretory cell	5 studies	22% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	18% ± 3%	Explore
pro-B cell	5 studies	32% ± 6%	Explore
vein endothelial cell	5 studies	28% ± 18%	Explore
lymphocyte	5 studies	30% ± 11%	Explore
respiratory goblet cell	5 studies	33% ± 9%	Explore
T follicular helper cell	5 studies	17% ± 2%	Explore
innate lymphoid cell	5 studies	18% ± 2%	Explore
goblet cell	5 studies	35% ± 24%	Explore
exhausted T cell	4 studies	20% ± 6%	Explore
retinal bipolar neuron	4 studies	20% ± 4%	Explore
glial cell	4 studies	27% ± 10%	Explore
plasma cell	4 studies	29% ± 11%	Explore
immature B cell	4 studies	22% ± 3%	Explore
amacrine cell	4 studies	25% ± 6%	Explore
retinal pigment epithelial cell	4 studies	32% ± 20%	Explore
cardiac muscle cell	4 studies	21% ± 1%	Explore
mesothelial cell	4 studies	28% ± 8%	Explore
Mueller cell	4 studies	23% ± 8%	Explore
hepatocyte	4 studies	47% ± 20%	Explore
hematopoietic stem cell	4 studies	29% ± 7%	Explore
enteroendocrine cell	4 studies	23% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	19% ± 2%	Explore
pancreatic A cell	3 studies	41% ± 19%	Explore
glomerular endothelial cell	3 studies	21% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	17% ± 1%	Explore
epithelial cell of proximal tubule	3 studies	20% ± 5%	Explore
neural crest cell	3 studies	19% ± 2%	Explore
GABAergic interneuron	3 studies	26% ± 6%	Explore
granule cell	3 studies	23% ± 4%	Explore
retinal ganglion cell	3 studies	25% ± 1%	Explore
GABAergic amacrine cell	3 studies	23% ± 7%	Explore
glycinergic amacrine cell	3 studies	20% ± 2%	Explore
rod bipolar cell	3 studies	24% ± 7%	Explore
germinal center B cell	3 studies	21% ± 3%	Explore
muscle cell	3 studies	38% ± 26%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	21% ± 6%	Explore
neural progenitor cell	3 studies	28% ± 8%	Explore
ependymal cell	3 studies	39% ± 15%	Explore
adventitial cell	3 studies	21% ± 4%	Explore
alveolar macrophage	3 studies	32% ± 9%	Explore
chondrocyte	3 studies	33% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	27% ± 10%	Explore
transit amplifying cell	3 studies	42% ± 33%	Explore
double negative thymocyte	3 studies	31% ± 15%	Explore
mucus secreting cell	3 studies	28% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	34% ± 17%	Explore
lung	12 studies	27% ± 7%	Explore
peripheral blood	12 studies	22% ± 9%	Explore
eye	7 studies	33% ± 14%	Explore
kidney	5 studies	19% ± 3%	Explore
liver	5 studies	32% ± 17%	Explore
intestine	5 studies	21% ± 8%	Explore
bone marrow	4 studies	23% ± 7%	Explore
heart	4 studies	20% ± 3%	Explore
lymph node	4 studies	18% ± 2%	Explore
adipose	4 studies	29% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5061.09	1445 / 1445	100%	36.12	183 / 183
prostate	100%	4657.27	245 / 245	100%	23.22	502 / 502
lung	100%	5078.70	578 / 578	100%	24.22	1154 / 1155
thymus	100%	5234.59	653 / 653	100%	19.12	604 / 605
uterus	100%	5235.59	170 / 170	100%	22.19	458 / 459
breast	100%	4461.56	459 / 459	100%	28.24	1115 / 1118
bladder	100%	4290.81	21 / 21	99%	22.39	501 / 504
ovary	100%	5300.43	180 / 180	99%	14.89	427 / 430
brain	99%	2397.41	2628 / 2642	100%	19.74	702 / 705
stomach	100%	3273.95	359 / 359	99%	28.83	283 / 286
intestine	100%	4700.21	966 / 966	99%	25.58	520 / 527
pancreas	100%	2539.14	328 / 328	98%	17.45	175 / 178
kidney	100%	3068.22	89 / 89	97%	14.97	874 / 901
adrenal gland	100%	4164.16	258 / 258	96%	11.59	221 / 230
skin	100%	5472.26	1809 / 1809	95%	20.79	447 / 472
liver	100%	2104.65	226 / 226	89%	9.64	362 / 406
adipose	100%	4039.35	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3822.16	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	20.56	29 / 29
muscle	100%	2493.58	803 / 803	0%	0	0 / 0
spleen	100%	4461.17	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	20.45	45 / 45
ureter	0%	0	0 / 0	100%	6.71	1 / 1
heart	98%	2077.75	846 / 861	0%	0	0 / 0
peripheral blood	69%	2643.05	641 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	69%	7.88	55 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0010793	Biological process	regulation of mRNA export from nucleus
GO_0010468	Biological process	regulation of gene expression
GO_0006397	Biological process	mRNA processing
GO_0017145	Biological process	stem cell division
GO_0006406	Biological process	mRNA export from nucleus
GO_0048699	Biological process	generation of neurons
GO_0010977	Biological process	negative regulation of neuron projection development
GO_0008380	Biological process	RNA splicing
GO_0048666	Biological process	neuron development
GO_0000902	Biological process	cell morphogenesis
GO_0001824	Biological process	blastocyst development
GO_0016973	Biological process	poly(A)+ mRNA export from nucleus
GO_0000445	Cellular component	THO complex part of transcription export complex
GO_0000346	Cellular component	transcription export complex
GO_0016607	Cellular component	nuclear speck
GO_0005654	Cellular component	nucleoplasm
GO_0000347	Cellular component	THO complex
GO_0000781	Cellular component	chromosome, telomeric region
GO_0003729	Molecular function	mRNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	THOC2
Protein name	THOC2 protein THO complex subunit 2 THO complex subunit 2 (Tho2) (hTREX120)
Synonyms	CXorf3
Description	FUNCTION: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as a component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development. .
Accessions	ENST00000618150.4 [Q8NI27-2] A0A0C4DG98 H0Y7U4 F2Z2V2 ENST00000432353.5 ENST00000433883.1 Q6P441 B7ZBA0 ENST00000441692.5 H0Y594 Q8NI27 ENST00000448128.5 ENST00000455053.5 ENST00000491737.5 H7C477 ENST00000416618.5 ENST00000355725.8 [Q8NI27-1] B7ZB98 ENST00000245838.13 [Q8NI27-1] H0Y815 ENST00000438358.1

THOC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review