TBCB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	29 studies	32% ± 10%	Explore
CD8-positive, alpha-beta T cell	27 studies	30% ± 13%	Explore
endothelial cell	27 studies	31% ± 14%	Explore
CD4-positive, alpha-beta T cell	24 studies	29% ± 11%	Explore
B cell	23 studies	24% ± 9%	Explore
fibroblast	23 studies	31% ± 12%	Explore
smooth muscle cell	22 studies	30% ± 10%	Explore
conventional dendritic cell	22 studies	31% ± 15%	Explore
non-classical monocyte	22 studies	37% ± 16%	Explore
T cell	21 studies	26% ± 9%	Explore
pericyte	21 studies	32% ± 10%	Explore
macrophage	20 studies	26% ± 9%	Explore
regulatory T cell	20 studies	32% ± 11%	Explore
plasmacytoid dendritic cell	17 studies	30% ± 11%	Explore
classical monocyte	17 studies	27% ± 12%	Explore
mature NK T cell	16 studies	31% ± 10%	Explore
dendritic cell	16 studies	38% ± 22%	Explore
monocyte	15 studies	24% ± 8%	Explore
endothelial cell of lymphatic vessel	14 studies	33% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	35% ± 12%	Explore
connective tissue cell	14 studies	33% ± 11%	Explore
mast cell	13 studies	22% ± 4%	Explore
memory B cell	13 studies	25% ± 5%	Explore
ciliated cell	13 studies	39% ± 16%	Explore
myofibroblast cell	13 studies	30% ± 10%	Explore
gamma-delta T cell	13 studies	33% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	32% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	21% ± 5%	Explore
naive B cell	11 studies	21% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	27% ± 8%	Explore
capillary endothelial cell	11 studies	25% ± 8%	Explore
endothelial cell of artery	11 studies	30% ± 13%	Explore
oligodendrocyte	10 studies	34% ± 15%	Explore
mucosal invariant T cell	10 studies	26% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	33% ± 13%	Explore
basal cell	9 studies	31% ± 16%	Explore
vein endothelial cell	9 studies	25% ± 7%	Explore
endothelial cell of vascular tree	9 studies	26% ± 6%	Explore
epithelial cell	9 studies	38% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	34% ± 11%	Explore
neuron	8 studies	53% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	30% ± 7%	Explore
myeloid cell	7 studies	26% ± 11%	Explore
abnormal cell	7 studies	40% ± 15%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	38% ± 13%	Explore
innate lymphoid cell	6 studies	25% ± 8%	Explore
type I pneumocyte	6 studies	26% ± 11%	Explore
T follicular helper cell	6 studies	27% ± 6%	Explore
exhausted T cell	5 studies	43% ± 8%	Explore
astrocyte	5 studies	34% ± 18%	Explore
enteroendocrine cell	5 studies	39% ± 21%	Explore
mesothelial cell	5 studies	31% ± 19%	Explore
glutamatergic neuron	5 studies	33% ± 17%	Explore
precursor B cell	5 studies	29% ± 8%	Explore
goblet cell	5 studies	20% ± 7%	Explore
hematopoietic precursor cell	4 studies	36% ± 16%	Explore
plasmablast	4 studies	52% ± 16%	Explore
pancreatic A cell	4 studies	53% ± 18%	Explore
leukocyte	4 studies	25% ± 8%	Explore
mononuclear phagocyte	4 studies	32% ± 14%	Explore
kidney loop of Henle epithelial cell	4 studies	22% ± 6%	Explore
retinal ganglion cell	4 studies	74% ± 28%	Explore
pro-B cell	4 studies	29% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	44% ± 7%	Explore
GABAergic neuron	4 studies	28% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	45% ± 10%	Explore
secretory cell	4 studies	31% ± 17%	Explore
T-helper 17 cell	4 studies	31% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	29% ± 4%	Explore
precursor cell	3 studies	42% ± 13%	Explore
type B pancreatic cell	3 studies	56% ± 4%	Explore
glomerular endothelial cell	3 studies	25% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	30% ± 10%	Explore
neural crest cell	3 studies	34% ± 11%	Explore
hematopoietic stem cell	3 studies	21% ± 7%	Explore
lymphocyte	3 studies	33% ± 12%	Explore
brush cell	3 studies	31% ± 11%	Explore
immature B cell	3 studies	28% ± 7%	Explore
amacrine cell	3 studies	49% ± 17%	Explore
retina horizontal cell	3 studies	38% ± 19%	Explore
retinal cone cell	3 studies	41% ± 17%	Explore
retinal rod cell	3 studies	35% ± 14%	Explore
microglial cell	3 studies	24% ± 8%	Explore
alveolar macrophage	3 studies	19% ± 1%	Explore
intraepithelial lymphocyte	3 studies	31% ± 5%	Explore
Mueller cell	3 studies	24% ± 8%	Explore
muscle cell	3 studies	32% ± 21%	Explore
germinal center B cell	3 studies	24% ± 6%	Explore
intermediate monocyte	3 studies	43% ± 17%	Explore
pancreatic ductal cell	3 studies	43% ± 13%	Explore
oligodendrocyte precursor cell	3 studies	39% ± 10%	Explore
granulocyte	3 studies	22% ± 8%	Explore
glial cell	3 studies	39% ± 20%	Explore
group 3 innate lymphoid cell	3 studies	31% ± 12%	Explore
T-helper 1 cell	3 studies	37% ± 8%	Explore
double negative thymocyte	3 studies	39% ± 13%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	21% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	30% ± 9%	Explore
lung	15 studies	28% ± 13%	Explore
brain	11 studies	27% ± 10%	Explore
kidney	7 studies	25% ± 7%	Explore
intestine	6 studies	27% ± 14%	Explore
eye	6 studies	32% ± 13%	Explore
lymph node	5 studies	30% ± 13%	Explore
placenta	4 studies	21% ± 5%	Explore
uterus	4 studies	30% ± 12%	Explore
pancreas	3 studies	54% ± 12%	Explore
bone marrow	3 studies	22% ± 7%	Explore
adrenal gland	3 studies	31% ± 12%	Explore
liver	3 studies	26% ± 8%	Explore
breast	3 studies	22% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	2714.21	258 / 258	100%	109.27	230 / 230
brain	100%	6992.06	2642 / 2642	100%	136.10	705 / 705
esophagus	100%	3254.91	1445 / 1445	100%	47.23	183 / 183
ovary	100%	3149.94	180 / 180	100%	90.66	430 / 430
uterus	100%	3694.00	170 / 170	100%	89.56	459 / 459
thymus	100%	2450.79	652 / 653	100%	63.98	604 / 605
skin	100%	2573.31	1807 / 1809	100%	85.65	471 / 472
kidney	100%	3082.42	89 / 89	99%	49.49	895 / 901
intestine	100%	3153.23	966 / 966	99%	61.43	523 / 527
prostate	100%	2871.48	245 / 245	99%	55.43	498 / 502
breast	100%	2981.98	459 / 459	99%	72.20	1108 / 1118
lung	99%	2838.54	575 / 578	99%	64.22	1145 / 1155
bladder	100%	3580.71	21 / 21	99%	78.37	497 / 504
stomach	99%	2035.39	356 / 359	99%	55.70	284 / 286
liver	87%	1084.51	197 / 226	96%	36.92	389 / 406
pancreas	80%	895.45	262 / 328	99%	64.27	176 / 178
adipose	100%	2908.19	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	66.85	80 / 80
lymph node	0%	0	0 / 0	100%	90.38	29 / 29
spleen	100%	3358.66	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	68.08	45 / 45
ureter	0%	0	0 / 0	100%	37.17	1 / 1
blood vessel	100%	4138.62	1334 / 1335	0%	0	0 / 0
heart	98%	2162.39	845 / 861	0%	0	0 / 0
peripheral blood	98%	2724.16	908 / 929	0%	0	0 / 0
muscle	95%	1594.51	764 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007023	Biological process	post-chaperonin tubulin folding pathway
GO_0007021	Biological process	tubulin complex assembly
GO_0030154	Biological process	cell differentiation
GO_0031122	Biological process	cytoplasmic microtubule organization
GO_0007399	Biological process	nervous system development
GO_0035371	Cellular component	microtubule plus-end
GO_0005829	Cellular component	cytosol
GO_0005938	Cellular component	cell cortex
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_0043014	Molecular function	alpha-tubulin binding
GO_0051010	Molecular function	microtubule plus-end binding

IV. Literature review

[source]

Gene name	TBCB
Protein name	Tubulin folding cofactor B Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B)
Synonyms	CKAP1 CG22
Description	FUNCTION: Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer . Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). .
Accessions	K7EL99 Q99426 ENST00000221855.8 [Q99426-1] ENST00000588385.5 K7EK42 K7EQH0 A0A494C0X0 ENST00000629269.2 K7ER04 K7EP07 ENST00000591296.1 ENST00000589624.5 ENST00000651435.1 ENST00000585746.1 [Q99426-2] ENST00000586868.1 ENST00000589996.5

TBCB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review