STAG2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	27 studies	30% ± 13%	Explore
natural killer cell	26 studies	24% ± 7%	Explore
B cell	23 studies	23% ± 7%	Explore
macrophage	21 studies	30% ± 13%	Explore
fibroblast	19 studies	26% ± 11%	Explore
classical monocyte	19 studies	24% ± 9%	Explore
CD8-positive, alpha-beta T cell	18 studies	22% ± 5%	Explore
T cell	17 studies	22% ± 7%	Explore
pericyte	17 studies	23% ± 10%	Explore
CD4-positive, alpha-beta T cell	15 studies	22% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	25% ± 6%	Explore
mast cell	13 studies	25% ± 8%	Explore
monocyte	13 studies	27% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	23% ± 4%	Explore
ciliated cell	13 studies	26% ± 11%	Explore
non-classical monocyte	13 studies	26% ± 10%	Explore
astrocyte	13 studies	30% ± 15%	Explore
regulatory T cell	13 studies	20% ± 6%	Explore
gamma-delta T cell	13 studies	25% ± 11%	Explore
endothelial cell of lymphatic vessel	12 studies	27% ± 12%	Explore
smooth muscle cell	12 studies	21% ± 5%	Explore
naive B cell	12 studies	22% ± 5%	Explore
mucosal invariant T cell	12 studies	21% ± 4%	Explore
microglial cell	11 studies	39% ± 12%	Explore
memory B cell	11 studies	20% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	24% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	25% ± 6%	Explore
oligodendrocyte	10 studies	40% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	26% ± 6%	Explore
mature NK T cell	10 studies	22% ± 6%	Explore
basal cell	9 studies	31% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	22% ± 7%	Explore
conventional dendritic cell	9 studies	24% ± 13%	Explore
myeloid cell	9 studies	29% ± 9%	Explore
epithelial cell	9 studies	39% ± 20%	Explore
glutamatergic neuron	8 studies	37% ± 24%	Explore
oligodendrocyte precursor cell	8 studies	35% ± 14%	Explore
plasmacytoid dendritic cell	8 studies	23% ± 8%	Explore
leukocyte	7 studies	37% ± 12%	Explore
GABAergic neuron	7 studies	41% ± 21%	Explore
type I pneumocyte	6 studies	22% ± 6%	Explore
capillary endothelial cell	6 studies	20% ± 5%	Explore
interneuron	6 studies	41% ± 23%	Explore
lymphocyte	6 studies	34% ± 16%	Explore
retinal cone cell	6 studies	33% ± 13%	Explore
retinal rod cell	6 studies	34% ± 9%	Explore
adipocyte	6 studies	26% ± 7%	Explore
dendritic cell	6 studies	33% ± 16%	Explore
Mueller cell	6 studies	29% ± 11%	Explore
myofibroblast cell	6 studies	21% ± 7%	Explore
mononuclear phagocyte	5 studies	23% ± 7%	Explore
abnormal cell	5 studies	22% ± 10%	Explore
neuron	5 studies	30% ± 16%	Explore
club cell	5 studies	27% ± 7%	Explore
retina horizontal cell	5 studies	25% ± 10%	Explore
endothelial cell of vascular tree	5 studies	27% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	22% ± 5%	Explore
innate lymphoid cell	5 studies	25% ± 10%	Explore
type II pneumocyte	5 studies	26% ± 7%	Explore
connective tissue cell	5 studies	22% ± 4%	Explore
goblet cell	5 studies	29% ± 22%	Explore
precursor B cell	4 studies	28% ± 9%	Explore
pro-B cell	4 studies	27% ± 3%	Explore
cardiac muscle cell	4 studies	19% ± 1%	Explore
endothelial cell of artery	4 studies	17% ± 1%	Explore
secretory cell	4 studies	22% ± 7%	Explore
T follicular helper cell	4 studies	19% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	26% ± 8%	Explore
hepatocyte	4 studies	37% ± 14%	Explore
muscle cell	4 studies	28% ± 21%	Explore
neutrophil	4 studies	21% ± 5%	Explore
ionocyte	3 studies	28% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	22% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	24% ± 7%	Explore
exhausted T cell	3 studies	24% ± 11%	Explore
hematopoietic precursor cell	3 studies	36% ± 14%	Explore
glomerular endothelial cell	3 studies	20% ± 1%	Explore
GABAergic interneuron	3 studies	19% ± 3%	Explore
glial cell	3 studies	27% ± 5%	Explore
progenitor cell	3 studies	25% ± 6%	Explore
brush cell	3 studies	29% ± 8%	Explore
immature B cell	3 studies	22% ± 3%	Explore
amacrine cell	3 studies	27% ± 8%	Explore
retinal bipolar neuron	3 studies	24% ± 4%	Explore
vein endothelial cell	3 studies	31% ± 20%	Explore
rod bipolar cell	3 studies	33% ± 9%	Explore
ependymal cell	3 studies	36% ± 10%	Explore
granulocyte	3 studies	22% ± 8%	Explore
hematopoietic stem cell	3 studies	23% ± 8%	Explore
enteroendocrine cell	3 studies	21% ± 4%	Explore
intestinal crypt stem cell	3 studies	18% ± 2%	Explore
transit amplifying cell	3 studies	40% ± 31%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	19% ± 1%	Explore
double negative thymocyte	3 studies	30% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	25% ± 7%	Explore
mural cell	3 studies	36% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	24% ± 9%	Explore
brain	12 studies	36% ± 19%	Explore
lung	9 studies	26% ± 9%	Explore
eye	8 studies	33% ± 15%	Explore
liver	5 studies	29% ± 14%	Explore
bone marrow	4 studies	22% ± 6%	Explore
heart	4 studies	19% ± 3%	Explore
intestine	4 studies	20% ± 6%	Explore
adipose	4 studies	24% ± 5%	Explore
kidney	4 studies	18% ± 4%	Explore
uterus	3 studies	26% ± 9%	Explore
lymph node	3 studies	17% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4411.98	1445 / 1445	100%	73.27	183 / 183
brain	100%	3452.86	2640 / 2642	100%	62.99	705 / 705
lung	100%	5002.65	578 / 578	100%	48.45	1154 / 1155
thymus	100%	5419.28	653 / 653	100%	60.24	604 / 605
prostate	100%	4058.60	245 / 245	100%	49.90	501 / 502
ovary	100%	6124.63	180 / 180	100%	38.22	429 / 430
breast	100%	5281.71	459 / 459	99%	59.97	1111 / 1118
stomach	100%	3226.29	359 / 359	99%	51.25	284 / 286
uterus	100%	5739.27	170 / 170	99%	47.60	454 / 459
pancreas	99%	2395.86	326 / 328	99%	36.33	177 / 178
intestine	100%	5234.57	966 / 966	99%	47.72	520 / 527
adrenal gland	100%	3869.74	258 / 258	98%	27.35	226 / 230
kidney	100%	2892.60	89 / 89	96%	40.86	866 / 901
bladder	100%	4690.48	21 / 21	94%	40.47	475 / 504
skin	100%	5131.53	1808 / 1809	91%	44.17	429 / 472
liver	100%	1641.55	225 / 226	86%	20.33	348 / 406
blood vessel	100%	5029.87	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	39.42	29 / 29
muscle	100%	3771.51	803 / 803	0%	0	0 / 0
spleen	100%	4250.06	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	50.67	45 / 45
ureter	0%	0	0 / 0	100%	16.27	1 / 1
adipose	100%	5241.00	1203 / 1204	0%	0	0 / 0
peripheral blood	97%	6160.94	899 / 929	0%	0	0 / 0
heart	95%	2135.25	818 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	74%	18.69	59 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007062	Biological process	sister chromatid cohesion
GO_0051301	Biological process	cell division
GO_0034087	Biological process	establishment of mitotic sister chromatid cohesion
GO_0090307	Biological process	mitotic spindle assembly
GO_0051321	Biological process	meiotic cell cycle
GO_0000775	Cellular component	chromosome, centromeric region
GO_0005730	Cellular component	nucleolus
GO_0097431	Cellular component	mitotic spindle pole
GO_0008278	Cellular component	cohesin complex
GO_0016020	Cellular component	membrane
GO_0005654	Cellular component	nucleoplasm
GO_0001650	Cellular component	fibrillar center
GO_0016363	Cellular component	nuclear matrix
GO_0005829	Cellular component	cytosol
GO_0030892	Cellular component	mitotic cohesin complex
GO_0005694	Cellular component	chromosome
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003682	Molecular function	chromatin binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	STAG2
Protein name	Cohesin subunit SA (SCC3 homolog) (Stromal antigen) Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2) Stromal antigen 2
Synonyms	SA2
Description	FUNCTION: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. . FUNCTION: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. . FUNCTION: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. . FUNCTION: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. .
Accessions	B1AMT2 B1AMT4 B1AMS8 ENST00000371144.7 [Q8N3U4-1] ENST00000371145.8 [Q8N3U4-2] ENST00000455404.5 ENST00000371157.7 [Q8N3U4-1] B1AMT1 ENST00000687852.1 [Q8N3U4-2] ENST00000435103.5 ENST00000455404.6 [Q8N3U4-1] ENST00000458176.5 ENST00000692982.1 ENST00000428941.5 ENST00000218089.13 [Q8N3U4-2] A0A8I5KVF8 ENST00000435215.5 B1AMS9 ENST00000458700.5 B1AMT0 ENST00000371160.5 [Q8N3U4-1] A0A8I5KUG8 ENST00000394478.1 ENST00000686127.1 B1AMT3 E7ERE6 Q8N3U4 ENST00000394477.5

STAG2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review