SENP6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	29 studies	38% ± 16%	Explore
fibroblast	25 studies	32% ± 15%	Explore
pericyte	24 studies	30% ± 15%	Explore
smooth muscle cell	21 studies	30% ± 12%	Explore
B cell	19 studies	25% ± 8%	Explore
astrocyte	19 studies	43% ± 19%	Explore
macrophage	19 studies	32% ± 18%	Explore
natural killer cell	16 studies	22% ± 6%	Explore
ciliated cell	15 studies	28% ± 12%	Explore
oligodendrocyte	15 studies	45% ± 17%	Explore
microglial cell	15 studies	49% ± 15%	Explore
oligodendrocyte precursor cell	14 studies	48% ± 20%	Explore
CD8-positive, alpha-beta T cell	14 studies	20% ± 3%	Explore
plasmacytoid dendritic cell	13 studies	27% ± 7%	Explore
naive B cell	13 studies	21% ± 3%	Explore
basal cell	12 studies	34% ± 19%	Explore
glutamatergic neuron	12 studies	50% ± 25%	Explore
CD4-positive, alpha-beta T cell	12 studies	21% ± 4%	Explore
mast cell	11 studies	25% ± 9%	Explore
endothelial cell of lymphatic vessel	11 studies	33% ± 15%	Explore
GABAergic neuron	11 studies	51% ± 23%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	21% ± 3%	Explore
epithelial cell	11 studies	41% ± 20%	Explore
memory B cell	11 studies	20% ± 3%	Explore
gamma-delta T cell	11 studies	23% ± 7%	Explore
T cell	10 studies	28% ± 8%	Explore
type I pneumocyte	10 studies	32% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	21% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	19% ± 3%	Explore
mucosal invariant T cell	10 studies	23% ± 5%	Explore
adipocyte	10 studies	38% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	22% ± 3%	Explore
non-classical monocyte	9 studies	24% ± 8%	Explore
regulatory T cell	9 studies	19% ± 2%	Explore
myofibroblast cell	9 studies	27% ± 14%	Explore
myeloid cell	9 studies	29% ± 8%	Explore
monocyte	9 studies	28% ± 11%	Explore
dendritic cell	9 studies	35% ± 14%	Explore
type II pneumocyte	8 studies	34% ± 13%	Explore
classical monocyte	8 studies	24% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	23% ± 4%	Explore
mature NK T cell	8 studies	21% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	19% ± 2%	Explore
leukocyte	7 studies	34% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	20% ± 3%	Explore
neuron	7 studies	45% ± 17%	Explore
retinal cone cell	7 studies	35% ± 12%	Explore
endothelial cell of artery	7 studies	20% ± 2%	Explore
capillary endothelial cell	6 studies	22% ± 7%	Explore
interneuron	6 studies	60% ± 24%	Explore
retinal ganglion cell	6 studies	39% ± 13%	Explore
club cell	6 studies	35% ± 13%	Explore
amacrine cell	6 studies	31% ± 11%	Explore
retina horizontal cell	6 studies	32% ± 12%	Explore
retinal rod cell	6 studies	30% ± 11%	Explore
vein endothelial cell	6 studies	29% ± 20%	Explore
Mueller cell	6 studies	37% ± 14%	Explore
secretory cell	5 studies	21% ± 4%	Explore
abnormal cell	5 studies	30% ± 17%	Explore
cardiac muscle cell	5 studies	37% ± 9%	Explore
mesothelial cell	5 studies	39% ± 16%	Explore
lymphocyte	5 studies	35% ± 16%	Explore
endothelial cell of vascular tree	5 studies	33% ± 20%	Explore
connective tissue cell	5 studies	30% ± 13%	Explore
goblet cell	5 studies	35% ± 28%	Explore
hematopoietic precursor cell	4 studies	31% ± 10%	Explore
conventional dendritic cell	4 studies	33% ± 17%	Explore
granule cell	4 studies	40% ± 4%	Explore
progenitor cell	4 studies	33% ± 6%	Explore
precursor B cell	4 studies	20% ± 2%	Explore
plasma cell	4 studies	31% ± 6%	Explore
retinal bipolar neuron	4 studies	31% ± 8%	Explore
retinal pigment epithelial cell	4 studies	45% ± 25%	Explore
OFF-bipolar cell	4 studies	29% ± 11%	Explore
respiratory goblet cell	4 studies	35% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	19% ± 3%	Explore
muscle cell	4 studies	37% ± 27%	Explore
hematopoietic stem cell	4 studies	25% ± 8%	Explore
kidney loop of Henle epithelial cell	4 studies	26% ± 12%	Explore
ionocyte	3 studies	25% ± 6%	Explore
glomerular endothelial cell	3 studies	17% ± 1%	Explore
podocyte	3 studies	32% ± 13%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	50% ± 1%	Explore
GABAergic interneuron	3 studies	48% ± 3%	Explore
glial cell	3 studies	34% ± 5%	Explore
immature B cell	3 studies	22% ± 2%	Explore
mononuclear phagocyte	3 studies	30% ± 7%	Explore
GABAergic amacrine cell	3 studies	39% ± 10%	Explore
ON-bipolar cell	3 studies	36% ± 9%	Explore
glycinergic amacrine cell	3 studies	33% ± 4%	Explore
rod bipolar cell	3 studies	36% ± 9%	Explore
innate lymphoid cell	3 studies	19% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	20% ± 6%	Explore
hepatocyte	3 studies	50% ± 20%	Explore
ependymal cell	3 studies	58% ± 13%	Explore
enteroendocrine cell	3 studies	27% ± 7%	Explore
intestinal crypt stem cell	3 studies	19% ± 5%	Explore
adventitial cell	3 studies	25% ± 9%	Explore
alveolar macrophage	3 studies	36% ± 11%	Explore
chondrocyte	3 studies	38% ± 15%	Explore
Schwann cell	3 studies	36% ± 21%	Explore
transit amplifying cell	3 studies	41% ± 32%	Explore
brush cell	3 studies	24% ± 6%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	32% ± 11%	Explore
renal alpha-intercalated cell	3 studies	28% ± 11%	Explore
renal principal cell	3 studies	27% ± 10%	Explore
mural cell	3 studies	49% ± 7%	Explore
mucus secreting cell	3 studies	31% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	24% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	46% ± 22%	Explore
lung	11 studies	25% ± 9%	Explore
peripheral blood	10 studies	23% ± 7%	Explore
eye	8 studies	36% ± 18%	Explore
heart	5 studies	30% ± 10%	Explore
liver	5 studies	31% ± 17%	Explore
bone marrow	4 studies	23% ± 10%	Explore
intestine	4 studies	22% ± 6%	Explore
adipose	4 studies	35% ± 10%	Explore
kidney	4 studies	29% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5613.86	1445 / 1445	100%	23.31	183 / 183
prostate	100%	6915.45	245 / 245	100%	29.31	502 / 502
breast	100%	6689.48	459 / 459	100%	29.16	1117 / 1118
lung	100%	5585.08	578 / 578	100%	20.77	1153 / 1155
brain	100%	3890.82	2636 / 2642	100%	23.66	705 / 705
thymus	100%	8005.81	653 / 653	100%	28.66	603 / 605
ovary	100%	8312.51	180 / 180	100%	15.49	428 / 430
uterus	100%	7983.05	170 / 170	99%	19.56	456 / 459
bladder	100%	6802.76	21 / 21	99%	18.18	499 / 504
pancreas	100%	3347.82	328 / 328	99%	18.08	176 / 178
intestine	100%	6537.82	966 / 966	98%	18.49	518 / 527
stomach	100%	4465.91	359 / 359	98%	19.19	280 / 286
adrenal gland	100%	4939.54	258 / 258	98%	17.44	225 / 230
kidney	100%	4812.66	89 / 89	97%	18.07	876 / 901
skin	100%	5479.43	1809 / 1809	92%	17.79	434 / 472
liver	100%	2410.40	226 / 226	88%	9.44	358 / 406
adipose	100%	6271.30	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7288.55	1335 / 1335	0%	0	0 / 0
muscle	100%	3675.79	803 / 803	0%	0	0 / 0
spleen	100%	5893.65	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	18.65	45 / 45
ureter	0%	0	0 / 0	100%	4.12	1 / 1
heart	97%	3068.85	834 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	13.14	28 / 29
peripheral blood	73%	2437.82	678 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	70%	9.46	56 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0070646	Biological process	protein modification by small protein removal
GO_0016925	Biological process	protein sumoylation
GO_0016926	Biological process	protein desumoylation
GO_0090169	Biological process	regulation of spindle assembly
GO_0090234	Biological process	regulation of kinetochore assembly
GO_0006508	Biological process	proteolysis
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0070139	Molecular function	SUMO-specific endopeptidase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SENP6
Protein name	SUMO specific peptidase 6 Alternative protein SENP6 Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6)
Synonyms	FKSG6 SUSP1 SSP1 KIAA0797
Description	FUNCTION: Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. .
Accessions	H0Y8Y8 L8E9U8 D6RG09 ENST00000503501.1 L8ECG3 ENST00000447266.7 [Q9GZR1-1] D6RJH1 ENST00000424947.6 ENST00000370010.6 [Q9GZR1-2] H0Y4F4 ENST00000483859.6 ENST00000493959.6 Q9GZR1 ENST00000327284.12 F8W6D9

SENP6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review