SELENOT | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	35 studies	33% ± 9%	Explore
B cell	32 studies	32% ± 11%	Explore
macrophage	30 studies	31% ± 12%	Explore
CD8-positive, alpha-beta T cell	29 studies	28% ± 8%	Explore
endothelial cell	25 studies	27% ± 12%	Explore
T cell	24 studies	29% ± 10%	Explore
CD4-positive, alpha-beta T cell	24 studies	29% ± 7%	Explore
conventional dendritic cell	22 studies	28% ± 12%	Explore
classical monocyte	22 studies	28% ± 10%	Explore
non-classical monocyte	19 studies	32% ± 13%	Explore
regulatory T cell	19 studies	32% ± 5%	Explore
plasmacytoid dendritic cell	18 studies	31% ± 10%	Explore
pericyte	17 studies	23% ± 7%	Explore
mature NK T cell	16 studies	31% ± 6%	Explore
memory B cell	16 studies	29% ± 6%	Explore
plasma cell	16 studies	45% ± 15%	Explore
naive B cell	16 studies	28% ± 7%	Explore
fibroblast	16 studies	28% ± 13%	Explore
monocyte	15 studies	28% ± 10%	Explore
gamma-delta T cell	14 studies	33% ± 10%	Explore
smooth muscle cell	14 studies	24% ± 8%	Explore
dendritic cell	14 studies	29% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	35% ± 7%	Explore
mast cell	12 studies	23% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	30% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	30% ± 8%	Explore
mucosal invariant T cell	11 studies	29% ± 6%	Explore
basal cell	11 studies	28% ± 13%	Explore
endothelial cell of lymphatic vessel	10 studies	28% ± 10%	Explore
plasmablast	10 studies	45% ± 22%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	23% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	27% ± 7%	Explore
connective tissue cell	10 studies	22% ± 5%	Explore
myeloid cell	10 studies	34% ± 11%	Explore
ciliated cell	10 studies	34% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	28% ± 9%	Explore
capillary endothelial cell	9 studies	22% ± 4%	Explore
epithelial cell	9 studies	38% ± 19%	Explore
abnormal cell	8 studies	27% ± 10%	Explore
endothelial cell of vascular tree	8 studies	23% ± 5%	Explore
oligodendrocyte	8 studies	24% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	29% ± 6%	Explore
leukocyte	7 studies	28% ± 9%	Explore
platelet	7 studies	27% ± 5%	Explore
T follicular helper cell	7 studies	36% ± 9%	Explore
astrocyte	7 studies	31% ± 15%	Explore
oligodendrocyte precursor cell	7 studies	28% ± 12%	Explore
alveolar macrophage	6 studies	26% ± 8%	Explore
mononuclear phagocyte	6 studies	34% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	32% ± 7%	Explore
kidney loop of Henle epithelial cell	6 studies	21% ± 3%	Explore
myofibroblast cell	6 studies	26% ± 7%	Explore
renal alpha-intercalated cell	6 studies	35% ± 8%	Explore
neuron	6 studies	32% ± 15%	Explore
endothelial cell of artery	6 studies	24% ± 5%	Explore
vein endothelial cell	6 studies	18% ± 4%	Explore
precursor B cell	6 studies	41% ± 8%	Explore
type I pneumocyte	6 studies	28% ± 13%	Explore
epithelial cell of proximal tubule	5 studies	19% ± 3%	Explore
IgA plasma cell	5 studies	22% ± 4%	Explore
IgG plasma cell	5 studies	28% ± 5%	Explore
pro-B cell	5 studies	31% ± 5%	Explore
innate lymphoid cell	5 studies	31% ± 4%	Explore
microglial cell	5 studies	27% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	30% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	33% ± 10%	Explore
GABAergic neuron	5 studies	37% ± 14%	Explore
secretory cell	5 studies	28% ± 8%	Explore
exhausted T cell	4 studies	37% ± 5%	Explore
lymphocyte	4 studies	27% ± 8%	Explore
megakaryocyte	4 studies	28% ± 5%	Explore
immature B cell	4 studies	30% ± 5%	Explore
retina horizontal cell	4 studies	29% ± 12%	Explore
germinal center B cell	4 studies	42% ± 14%	Explore
CD4-positive helper T cell	4 studies	27% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	30% ± 4%	Explore
glutamatergic neuron	4 studies	46% ± 15%	Explore
neutrophil	4 studies	19% ± 1%	Explore
duct epithelial cell	3 studies	16% ± 1%	Explore
pancreatic A cell	3 studies	64% ± 16%	Explore
type B pancreatic cell	3 studies	54% ± 23%	Explore
hematopoietic precursor cell	3 studies	33% ± 5%	Explore
glomerular endothelial cell	3 studies	19% ± 3%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	23% ± 4%	Explore
retinal bipolar neuron	3 studies	42% ± 16%	Explore
OFF-bipolar cell	3 studies	23% ± 5%	Explore
retinal ganglion cell	3 studies	56% ± 26%	Explore
placental villous trophoblast	3 studies	32% ± 15%	Explore
club cell	3 studies	34% ± 9%	Explore
enterocyte	3 studies	18% ± 3%	Explore
amacrine cell	3 studies	44% ± 11%	Explore
retinal cone cell	3 studies	59% ± 19%	Explore
retinal rod cell	3 studies	32% ± 13%	Explore
tissue-resident macrophage	3 studies	27% ± 10%	Explore
intraepithelial lymphocyte	3 studies	37% ± 10%	Explore
Mueller cell	3 studies	46% ± 14%	Explore
rod bipolar cell	3 studies	30% ± 8%	Explore
intermediate monocyte	3 studies	40% ± 21%	Explore
granulocyte	3 studies	29% ± 10%	Explore
IgM plasma cell	3 studies	35% ± 15%	Explore
enteroendocrine cell	3 studies	37% ± 22%	Explore
goblet cell	3 studies	28% ± 8%	Explore
intestinal crypt stem cell	3 studies	20% ± 4%	Explore
glial cell	3 studies	28% ± 14%	Explore
group 3 innate lymphoid cell	3 studies	41% ± 10%	Explore
T-helper 17 cell	3 studies	36% ± 6%	Explore
interneuron	3 studies	42% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	28% ± 6%	Explore
double negative thymocyte	3 studies	38% ± 9%	Explore
T-helper 1 cell	3 studies	40% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	28% ± 10%	Explore
peripheral blood	14 studies	31% ± 8%	Explore
kidney	8 studies	24% ± 4%	Explore
eye	8 studies	28% ± 13%	Explore
brain	7 studies	37% ± 11%	Explore
intestine	6 studies	24% ± 10%	Explore
liver	5 studies	30% ± 17%	Explore
placenta	4 studies	26% ± 13%	Explore
bone marrow	4 studies	20% ± 5%	Explore
uterus	4 studies	28% ± 12%	Explore
breast	4 studies	22% ± 4%	Explore
pancreas	3 studies	55% ± 23%	Explore
lymph node	3 studies	27% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	5432.66	2642 / 2642	100%	119.10	705 / 705
esophagus	100%	3621.75	1445 / 1445	100%	84.52	183 / 183
lung	100%	4056.69	578 / 578	100%	101.74	1155 / 1155
ovary	100%	3015.86	180 / 180	100%	88.02	430 / 430
uterus	100%	3587.94	170 / 170	100%	77.50	459 / 459
bladder	100%	3439.14	21 / 21	100%	75.71	503 / 504
kidney	100%	3559.08	89 / 89	100%	74.08	899 / 901
breast	100%	3560.27	459 / 459	100%	105.87	1115 / 1118
thymus	100%	4141.02	653 / 653	100%	96.55	603 / 605
stomach	100%	3182.49	359 / 359	100%	69.09	285 / 286
intestine	100%	3677.83	966 / 966	100%	67.15	525 / 527
pancreas	100%	2427.35	328 / 328	99%	67.10	177 / 178
prostate	100%	3675.87	244 / 245	100%	102.23	501 / 502
liver	100%	2969.98	226 / 226	99%	42.93	401 / 406
adrenal gland	100%	6530.16	258 / 258	99%	74.81	227 / 230
skin	100%	3251.51	1803 / 1809	94%	57.34	442 / 472
adipose	100%	3719.46	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	107.97	29 / 29
spleen	100%	4262.41	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	82.56	45 / 45
ureter	0%	0	0 / 0	100%	33.67	1 / 1
blood vessel	100%	4018.26	1333 / 1335	0%	0	0 / 0
muscle	100%	2545.56	800 / 803	0%	0	0 / 0
heart	98%	3033.83	843 / 861	0%	0	0 / 0
peripheral blood	97%	5328.27	901 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	49%	12.57	39 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0060124	Biological process	positive regulation of growth hormone secretion
GO_0045454	Biological process	cell redox homeostasis
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0098869	Biological process	cellular oxidant detoxification
GO_0001514	Biological process	selenocysteine incorporation
GO_0031016	Biological process	pancreas development
GO_0009749	Biological process	response to glucose
GO_0042593	Biological process	glucose homeostasis
GO_0035773	Biological process	insulin secretion involved in cellular response to glucose stimulus
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0008430	Molecular function	selenium binding
GO_0004791	Molecular function	thioredoxin-disulfide reductase (NADPH) activity

IV. Literature review

[source]

Gene name	SELENOT
Protein name	Selenoprotein T Thioredoxin reductase-like selenoprotein T (SelT) (EC 1.8.1.9)
Synonyms	SELT hCG_20913 UNQ150/PRO176
Description	FUNCTION: Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress and cell death . Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity). .
Accessions	ENST00000480740.5 P62341 ENST00000492132.1 ENST00000471696.6 ENST00000485923.1 ENST00000477889.5 F8WBD0 F6U0C2

SELENOT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review